Results 41 to 50 of about 24,158,011 (265)

Affinity and Kinetic Analysis of P-selectin Binding to P-selectin Glycoprotein Ligand-1 [PDF]

Journal of Biological Chemistry, 1998
Leukocytes use the cell-surface mucin P-selectin glycoprotein ligand-1 (PSGL-1) to tether to and roll on P-selectin on activated endothelial cells and platelets. By using surface plasmon resonance, we measured the affinity and kinetics of binding of soluble monomeric human P-selectin to immobilized PSGL-1 from human neutrophils.
P, Mehta, R D, Cummings, R P, McEver
openaire   +2 more sources

تغییرات سرمی E-selectin و P-selectin در مردان مبتلا به نارسایی قلبی پس از هشت هفته تمرین هوازی تداومی و تناوبی [PDF]

مجله دانشگاه علوم پزشکی سبزوار, 2020
زمینه و هدف  مولکول‌های چسبان، نشانگرهای سلولی شناسایی روند تشکیل پلاک آترواسکلروزی دیواره اندوتلیال عروق هستند. هدف، بررسی تغییرات سرمی E-selectin و P-selectin در مردان مبتلا به نارسایی قلبی، پس از هشت هفته تمرین هوازی تداومی و تناوبی بود. مواد و روش‌ها
لادن حسینی ابریشمی, سید محمود حجازی, امیر رشیدلمیر   +2 more
doaj  

The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium.

PLoS ONE, 2020
Acute inflammation begins with leukocyte P-selectin glycoprotein ligand-1 (PSGL-1) binding to P-selectin on inflamed endothelium and platelets. In pathologic conditions, this process may contribute to secondary organ damage, like sepsis-induced liver ...
Fong Wilson Lam, Cameron August Brown, Christian Valladolid, Dabel Cynthia Emebo, Timothy Gerald Palzkill, Miguel Angel Cruz   +5 more
doaj   +1 more source

Glycosylation inhibitors efficiently inhibit P-selectin-mediated cell adhesion to endothelial cells. [PDF]

PLoS ONE, 2014
Adhesion molecules play a critical role in the adhesive interactions of multiple cell types in sickle cell disease (SCD). We previously showed that anti-P-selectin aptamer efficiently inhibits cell adhesion to endothelial cells (ECs) and permits SCD mice
Pushpankur Ghoshal, Mythilypriya Rajendran, Nadine Odo, Tohru Ikuta   +3 more
doaj   +1 more source

Biodistribution of P-selectin targeted microbubbles [PDF]

Journal of Drug Targeting, 2014
To evaluate binding of P-selectin targeted microbubbles (MB) in tumor vasculature; a whole-body imaging and biodistribution study was performed in a tumor bearing mouse model.Antibodies were radiolabeled with Tc-99 m using the HYNIC method. Tc-99 m labeled anti-P-selectin antibodies were avidin-bound to lipid-shelled, perfluorocarbon gas-filled MB and ...
Jason M, Warram, Anna G, Sorace, Marshall, Mahoney, Sharon, Samuel, Bryant, Harbin, Madhura, Joshi, Amber, Martin, Lee, Whitworth, Kenneth, Hoyt, Kurt R, Zinn   +9 more
openaire   +2 more sources

Video_1_Nanodiamond-Induced Thrombocytopenia in Mice Involve P-Selectin-Dependent Nlrp3 Inflammasome-Mediated Platelet Aggregation, Pyroptosis and Apoptosis.mp4

, 2022
Nanodiamond (ND) has been developed as a carrier to conduct various in vivo diagnostic and therapeutic uses. Safety is one of the major considerations, while the hemocompatibility of ND is not clearly addressed.
Lu-Chu Ke (12339820), Hsin-Hou Chang (221399), Te-Sheng Lien (359060), Hsuan-Shun Huang (359058), Chia-Liang Cheng (2476663), Shih-Che Hung (10314449), Der-Shan Sun (331824)   +6 more
core   +1 more source

Core and shell platelets of a thrombus: A new microfluidic assay to study mechanics and biochemistry

Research and Practice in Thrombosis and Haemostasis, 2020
Background Hemostatic clots have a P‐selectin positive platelet core covered with a shell of P‐selectin negative platelets. Objective To develop a new human blood microfluidic assay to interrogate core/shell mechanics.
Michael E. DeCortin, Lawrence F. Brass, Scott L. Diamond   +2 more
doaj   +1 more source

DataSheet_1_Nanodiamond-Induced Thrombocytopenia in Mice Involve P-Selectin-Dependent Nlrp3 Inflammasome-Mediated Platelet Aggregation, Pyroptosis and Apoptosis.docx

, 2022
Nanodiamond (ND) has been developed as a carrier to conduct various in vivo diagnostic and therapeutic uses. Safety is one of the major considerations, while the hemocompatibility of ND is not clearly addressed.
Lu-Chu Ke (12339820), Hsin-Hou Chang (221399), Te-Sheng Lien (359060), Hsuan-Shun Huang (359058), Chia-Liang Cheng (2476663), Shih-Che Hung (10314449), Der-Shan Sun (331824)   +6 more
core   +1 more source

Circulating selectins as potential biomarkers for sarcopenia: a case-control study

Frontiers in Medicine
BackgroundThis study investigates the association between circulating E-selectin, L-selectin, and P-selectin levels and sarcopenia in older adults.MethodsWe conducted a case-control study of 325 older adults (261 controls, 64 sarcopenia cases ...
Hu Zhang, Huaqing Liu, Yanhui Tang, Jiatong Wu, Mingyang Du, Yanhua Song, Nannan Wang, Jianfeng Wang   +7 more
doaj   +1 more source

Force-dependent calcium signaling and its pathway of human neutrophils on P-selectin in flow

Protein & Cell, 2017
P-selectin engagement of P-selectin glycoprotein ligand-1 (PSGL-1) causes circulating leukocytes to roll on and adhere to the vascular surface, and mediates intracellular calcium flux, a key but unclear event for subsequent arresting firmly at and ...
Bing Huang, Yingchen Ling, Jiangguo Lin, Xin Du, Ying Fang, Jianhua Wu   +5 more
doaj   +1 more source