Results 41 to 50 of about 53,857 (243)

Plasma substance P and soluble P-selectin as biomarkers of β-thalassemia induced hypercoagulability

Alexandria Journal of Medicine, 2014
Background: Hypercoagulability in thalassemia especially in thalassemia major has emerged as a complication of the disease. There is evidence of increased platelet aggregation and increased proportion of platelets expressing P-selectin in thalassemia.
Samia A. Ebeid, Nadia A. Sadek, Sanaa A. El-Benhawy, Gihan N. Mahmoud   +3 more
doaj   +1 more source

P-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces. [PDF]

PLoS ONE, 2013
Interactions of selectins with cell surface glycoconjugates mediate the first step of the adhesion and signaling cascade that recruits circulating leukocytes to sites of infection or injury.
Yan Zhang, Ning Jiang, Veronika I Zarnitsyna, Arkadiusz G Klopocki, Rodger P McEver, Cheng Zhu   +5 more
doaj   +1 more source

Antibodies cross-reactive with E- and P-selectin block both E- and P- selectin functions [PDF]

Blood, 1995
E- and P-selectin are inflammation-induced cell adhesion molecules that mediate leukocyte-endothelial cell and leukocyte-platelet interactions. Monoclonal antibodies (MoAbs) specific for either E-selectin or P- selectin are protective in several animal models of inflammatory disease.
E L, Berg, C, Fromm, J, Melrose, N, Tsurushita   +3 more
openaire   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Soluble P-selectin levels in synovial fluid and serum from patients with psoriatic arthritis

Reumatismo, 2011
Objective: P-selectin is an adhesion molecule expressed by activated endothelial cells and platelets favouring the leukocyte adherence to microvascular endothelium.
G. Valesini, D. Celestino, M. Di Franco, M. Bombardieri, V. Riccieri, A. Spadaro, R. Scrivo   +6 more
doaj   +1 more source

Noncovalent Association of P-selectin Glycoprotein Ligand-1 and Minimal Determinants for Binding to P-selectin [PDF]

Journal of Biological Chemistry, 2000
P-selectin glycoprotein ligand-1 (PSGL-1) is a disulfide-bonded, homodimeric mucin ( approximately 250 kDa) on leukocytes that binds to P-selectin on platelets and endothelial cells during the initial steps in inflammation. Because it has been proposed that only covalently dimerized PSGL-1 can bind P-selectin, we investigated the factors controlling ...
T K, Epperson, K D, Patel, R P, McEver, R D, Cummings   +3 more
openaire   +2 more sources

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

Advanced Science, EarlyView.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka, Ana María Pablo‐Sainz‐Ezquerra, Eva Jakljevič, Niki Ktena, Leticia Hosta‐Rigau   +4 more
wiley   +1 more source

Soluble P-selectin and L-selectin levels in serum of colorectal cancer patients and its clinical significance

Zhongguo aizheng zazhi, 2014
Background and purpose: Colorectal cancer is a kind of common digestive malignancies, which seriously threaten the human health. Although modern diagnostic and treatment technology has developed rapidly, the incidence and mortality of colorectal cancer ...
张梁, 罗桂飞, 元辉雄, 韦贵将
doaj  

Maternal, Fetal, and Placental Selectins in Women With Pre-eclampsia; Association With the Renin-Angiotensin-System

Frontiers in Medicine, 2020
Selectins [endothelial (E), platelet (P), and leucocytes (L)] are a class of cell adhesion molecules, stimulated in response to inflammation. Pre-eclampsia is characterized by inflammation, and angiotensin II is pro-inflammatory.
Hiten D. Mistry, Melissa V. Hott Ogalde, Fiona Broughton Pipkin, Geneviève Escher, Geneviève Escher, Lesia O. Kurlak   +5 more
doaj   +1 more source

Soluble P-selectin is the smoke, not the fire [PDF]

Blood, 2017
In this issue of Blood , Panicker and colleagues have clarified the role of soluble P-selectin (sP-selectin) in inflammation and cardiovascular disease by showing that monomeric sP-selectin, the form that circulates in plasma, does not promote inflammation or promote coagulation, but the dimeric form of P-selectin does ...
openaire   +2 more sources