Results 41 to 50 of about 80,651 (264)

Circulating selectins as potential biomarkers for sarcopenia: a case-control study

Frontiers in Medicine
BackgroundThis study investigates the association between circulating E-selectin, L-selectin, and P-selectin levels and sarcopenia in older adults.MethodsWe conducted a case-control study of 325 older adults (261 controls, 64 sarcopenia cases ...
Hu Zhang, Huaqing Liu, Yanhui Tang, Jiatong Wu, Mingyang Du, Yanhua Song, Nannan Wang, Jianfeng Wang   +7 more
doaj   +1 more source

Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level

BMC Medical Genetics, 2012
Background E-selectin is implicated in various inflammatory processes and related disorders. We aimed to investigate the role of SELE-gene genotypes/haplotypes on plasma levels of MMP9 and sE-selectin in Taiwanese individuals. Methods Five hundred twenty
Wu Semon, Hsu Lung-An, Teng Ming-Sheng, Lin Jeng-Feng, Chang Hsien-Hsun, Sun Yu-Chen, Chen Hsuan-Pu, Ko Yu-Lin   +7 more
doaj   +1 more source

P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin. [PDF]

The Journal of cell biology, 1995
Neutrophils roll on P-selectin expressed by activated platelets or endothelial cells under the shear stresses in the microcirculation. P-selectin glycoprotein ligand-1 (PSGL-1) is a high affinity ligand for P-selectin on myeloid cells. However, it has not been demonstrated that PSGL-1 contributes to the rolling of neutrophils on P-selectin.
K L, Moore, K D, Patel, R E, Bruehl, F, Li, D A, Johnson, H S, Lichenstein, R D, Cummings, D F, Bainton, R P, McEver   +8 more
openaire   +2 more sources

Circulating P-Selectin Glycoprotein Ligand 1 and P-Selectin Levels in Obstructive Sleep Apnea Patients [PDF]

Lung, 2020
Abstract Purpose Obstructive sleep apnea (OSA) is characterized by chronic intermittent hypoxia which induces inflammation in blood vessels leading to the development of cardiovascular comorbidities. Several studies implicated the role of P-selectin in vascular inflammation of OSA.
P. Horváth, Z. Lázár, G. Gálffy, R. Puskás, L. Kunos, Gy. Losonczy, M. Mészáros, Á. D. Tárnoki, D. L. Tárnoki, A. Bikov   +9 more
openaire   +3 more sources

Clinical utility of remote platelet function measurement using P-selectin: assessment of aspirin, clopidogrel, and prasugrel and bleeding disorders [PDF]

, 2018
Vascular diseases such as myocardial infarction and ischemic stroke are associated with increased platelet function whilst the risk of recurrence is reduced by antiplatelet agents such as aspirin, clopidogrel, and prasugrel.
Adamany J, Bath PM, May J, Flaherty K, Woodhouse LJ, Dovlatova N, Fox SC, England TJ, Krishnan K, Robinson TG, Sprigg N, et al., Bath PM, Woodhouse LJ, Appleton JP, Beridze M, Christensen H, Dineen RA, Duley L, England TJ, Flaherty K, Havard D, et al., Cardoso RN, Benjo AM, DiNicolantonio JJ, Garcia DC, Macedo FY, El-Hayek G, Nadkarni GN, Gili S, Iannaccone M, Konstantinidis I, et al., Dovlatova N, Fox SC, May JA, Dovlatova N, Glenn JR, Johnson A, White AE, Radhakrishnan A, Heptinstall S., Heptinstall S, Heptinstall S, Heptinstall S, Jane May, Laohathai P, Joshi R, Radhakrishnan A, May J, Dovlatova N, Heptinstall S, Fox S., May J, Philip M Bath, Stan Heptinstall, TARDIS Trial Investigators, Krishnan K, Beridze M, Christensen H, Dineen R, Duley L, Heptinstall S, James M, Markus H, Pocock S, et al., Vlachojannis G   +15 more
core   +2 more sources

Further Findings Concerning Endothelial Damage in COVID-19 Patients

Biomolecules, 2021
Systemic vascular damage with micro/macro-thrombosis is a typical feature of severe COVID-19. However, the pathogenesis of this damage and its predictive biomarkers remain poorly defined. For this reason, in this study, serum monocyte chemotactic protein
Monica Gelzo, Sara Cacciapuoti, Biagio Pinchera, Annunziata De Rosa, Gustavo Cernera, Filippo Scialò, Marika Comegna, Mauro Mormile, Gabriella Fabbrocini, Roberto Parrella, Gaetano Corso, Ivan Gentile, Giuseppe Castaldo   +12 more
doaj   +1 more source

Targeting P-selectin blocks neuroblastoma growth

Oncotarget, 2017
Selectins and their ligands have been implicated in tumor growth and progression in carcinomas, but their role in neuroblastoma has not been systematically examined. In the current study we evaluated L-, P- and E-selectin binding to neuroblastoma cells and the expression of some of their known ligands, namely CD44, CD24 and P-selectin glycoprotein ...
Nolo, Riitta, Herbrich, Shelley, Rao, Arvind, Zweidler-McKay, Patrick, Kannan, Sankaranarayanan, Gopalakrishnan, Vidya   +5 more
openaire   +2 more sources

Prognostic value of P-selectin and sST2 in patients with multiple myeloma

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022
Cardiac involvement is one of the most important prognostic markers in multiple myeloma. However, prognostic value of novel biomarkers, such as soluble suppression of tumorigenicity 2 (sST2), P-selectin is unknown in multiple myeloma.
M. O. Panasenko, B. B. Samura, S. Ya. Dotsenko   +2 more
doaj   +1 more source

Lack of influence of the COX inhibitors metamizol and diclofenac on platelet GPIIb/IIIa and P-selectin expression [PDF]

, 2004
Background The effect of non-steroidal anti-inflammatory drugs (NSAIDs) for reduced platelet aggregation and thromboxane A2 synthesis has been well documented. However, the influence on platelet function is not fully explained.
Dirk Scheinichen, Holger-Andreas Elsner, Rodin Osorio, Björn Jüttner, Werner Gröschel, Karsten Jaeger, Siegfried Piepenbrock, MJ Peters, MJ Peters, EM Cramer, YK Liu, M Gawaz, V Evangelista, JR Vane, AI Schafer, A Schmidt, K Perttunen, J Laitinen, G Geisslinger, A Eldor, J Golanski, P Failli, A Van Hecken, P Patrignani, J Bozzo, R Abbate, H Holmsen, S Cronberg, A Eldor, C Domínguez-Jiménez, G Andrioli, MD Nyby, P Fonlupt, S Cortelazzo, SA Saeed   +34 more
core   +1 more source

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source