Results 11 to 20 of about 74,821 (300)
Selectin-Mediated Signaling—Shedding Light on the Regulation of Integrin Activity in Neutrophils
Cells, 2022 As a consequence of tissue injury or infection, neutrophils are recruited in a stepwise recruitment process from the bloodstream into the surrounding tissue. Selectins are a family of adhesion molecules comprised of L-, E-, and P-selectin. Differences in
Anika Cappenberg +2 more
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Role of CD34 in inflammatory bowel disease
Frontiers in Physiology, 2023 Inflammatory bowel disease (IBD) is caused by a variety of pathogenic factors, including chronic recurrent inflammation of the ileum, rectum, and colon.
Zhiyuan Li +10 more
doaj +1 more source
Lipoprotein sialylation in atherosclerosis: Lessons from mice
Frontiers in Endocrinology, 2022 Sialylation is a dynamically regulated modification, which commonly occurs at the terminal of glycan chains in glycoproteins and glycolipids in eukaryotic cells.
Liming Yu +3 more
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Targeting selectins and selectin ligands in inflammation and cancer [PDF]
Expert Opinion on Therapeutic Targets, 2007 Inflammation and cancer metastasis are associated with extravasation of leukocytes or tumor cells from blood into tissue. Such movement is believed to follow a coordinated and sequential molecular cascade initiated, in part, by the three members of the selectin family of carbohydrate-binding proteins: E-selectin (CD62E), L-selectin (CD62L) and P ...
Steven R, Barthel +3 more
openaire +2 more sources
Targeting Neutrophil Adhesive Events to Address Vaso-Occlusive Crisis in Sickle Cell Patients
Frontiers in Immunology, 2021 Neutrophils are essential to protect the host against invading pathogens but can promote disease progression in sickle cell disease (SCD) by becoming adherent to inflamed microvascular networks in peripheral tissue throughout the body.
Vasilios A. Morikis +4 more
doaj +1 more source
Selectin and selectin ligand binding: a bittersweet attraction [PDF]
Journal of Clinical Investigation, 2003 Inhibition of leukocyte migration into target organs has long been an attractive, though challenging, basis for anti-inflammatory strategies. However, to date, the manipulation of leukocyte rolling along blood vessels has not yielded successful new therapies.
Thomas M, Zollner, Khusru, Asadullah
openaire +2 more sources
Role of P-selectin in platelet sequestration in pulmonary capillaries during endotoxemia [PDF]
, 2006 Background: There is growing evidence that platelets accumulate in the lung and contribute to the pathogenesis of acute lung injury during endotoxemia.
Schenkat, Sonja +4 more
core +1 more source
, 2022 AimsNovel cell-based therapeutic angiogenic treatments for patients with critical limb ischemia may afford limb salvage. Mesenchymal stem cells (MSCs) do not overexpress E-selectin; however, we have previously demonstrated the cell-adhesion molecule's ...
Roberta M. Lassance-Soares (12021782) +9 more
core +1 more source
Frontiers in Cardiovascular Medicine, 2017 ObjectiveHigher circulating concentrations of cellular adhesion molecules (CAMs) can be used as markers of endothelial dysfunction. Given that the brain is highly vascularized, we assessed whether endothelial function is associated with cognitive ...
Cynthia Yursun Yoon +9 more
doaj +1 more source
, 2022 Nanodiamond (ND) has been developed as a carrier to conduct various in vivo diagnostic and therapeutic uses. Safety is one of the major considerations, while the hemocompatibility of ND is not clearly addressed.
Lu-Chu Ke (12339820) +6 more
core +1 more source