Results 31 to 40 of about 74,821 (300)
MAPK phosphatase-1 represents a novel antiinflammatory target of glucocorticoids in the human endothelium [PDF]
, 2007 Glucocorticoids are well-established anti- inflammatory drugs thought to mainly act by inhibition of proinflammatory transcription factors like NF-κB.
Timm Schroeder +20 more
core +1 more source
, 2022 Activation of integrins is crucial for recruitment of flowing leukocytes to inflammatory or injured vascular sites, but their spatiotemporal characteristics are incompletely understood. We discovered that β2-integrin activation over the entire surface of
Quhuan Li (9666770) +11 more
core +1 more source
Pharmaceuticals, 2017 Endothelial cell (EC) dysfunction is associated with many disease states including deep vein thrombosis (DVT), chronic kidney disease, sepsis and diabetes.
James R. Wodicka +4 more
doaj +1 more source
Bromelain decreases neutrophil interactions with P-selectin, but not E-selectin, in vitro by proteolytic cleavage of P-selectin glycoprotein ligand-1. [PDF]
PLoS ONE, 2013 Stem bromelain, a cysteine protease isolated from pineapples, is a natural anti-inflammatory treatment, yet its mechanism of action remains unclear. Curious as to whether bromelain might affect selectin-mediated leukocyte rolling, we studied the ability ...
Jessica M Banks +2 more
doaj +1 more source
, 2022 Activation of integrins is crucial for recruitment of flowing leukocytes to inflammatory or injured vascular sites, but their spatiotemporal characteristics are incompletely understood. We discovered that β2-integrin activation over the entire surface of
Quhuan Li (9666770) +11 more
core +1 more source
Saikosaponin D Isolated from Bupleurum falcatum Inhibits Selectin-Mediated Cell Adhesion
Molecules, 2014 Three saikosaponins were isolated from the MeOH extract of the roots of Bupleurum falcatum L.: saikosaponins B3 (1); B4 (2); and D (3). Of the three, compound 3 inhibited the interaction of selectins (E, L, and P) and THP-1 cells with IC50 values of 1.8,
Myoung-Jun Jang +7 more
doaj +1 more source
Frontiers in Immunology, 2018 Neutrophils are the most motile of mammalian cells, a feature that enables them to protect the host against the rapid spread of pathogens from tissue into the circulatory system.
Vasilios A. Morikis, Scott I. Simon
doaj +1 more source
CD44v4 is a major E-selectin ligand that mediates breast cancer cell transendothelial migration. [PDF]
PLoS ONE, 2008 BACKGROUND: Endothelial E-selectin has been shown to play a pivotal role in mediating cell-cell interactions between breast cancer cells and endothelial monolayers during tumor cell metastasis.
Ke Zen +7 more
doaj +1 more source
Towards the synthesis of a macrocyclic E-selectin antagonist [PDF]
, 2006 Towards the Synthesis of a Macrocyclic E-selectin Antagonis: Introduction: Selectins are involved in the orderly migration of leukocytes from blood vessels to sites of inflammation.
Marti, Sébastien Jérôme Georges
core +1 more source
Czech Journal of Animal Science, 2016 The goal of this work was to understand how polymorphonuclear leukocytes (PMN), the first line of cellular defence, integrate and prioritize multiple chemotactic signals to navigate during periods of demand like subclinical mastitis (SCM), clinical ...
M. Alhussien +7 more
doaj +1 more source