Results 31 to 40 of about 14,056 (288)

The influence of tobacco smoking on adhesion molecule profiles

Tobacco Induced Diseases, 2002
Sequential interactions between several adhesion molecules and their ligands regulate lymphocyte circulation and leukocyte recruitment to inflammatory foci. Adhesion molecules are, therefore, central and critical components of the immune and inflammatory
DA Scott, RM Palmer
doaj   +1 more source

Systematic Review and Meta-Analysis of the Effect of Statins on Circulating E-Selectin, L-Selectin, and P-Selectin [PDF]

Biomedicines, 2021
The pleiotropic effects of statins might involve preventing inflammatory cell adhesion to the endothelium, which is a critical step in the pathogenesis of atherosclerosis. We conducted a systematic review and meta-analysis of the effects of statins on the circulating cell adhesion molecules E-Selectin, L-Selectin, and P-Selectin.
Angelo Zinellu, Arduino A. Mangoni
openaire   +3 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Glycobiology of Eosinophilic Inflammation: Contributions of Siglecs, Glycans, and Other Glycan-Binding Proteins

Frontiers in Medicine, 2017
The historical focus on protein–protein interactions in biological systems, at the expense of attention given to interactions between other classes of molecules, has overlooked important and clinically relevant processes and points of potential clinical ...
Jeremy A. O’Sullivan, Daniela J. Carroll, Bruce S. Bochner   +2 more
doaj   +1 more source

Dysregulation of Biomarkers of Hemostatic Activation and Inflammatory Processes are Associated with Adverse Outcomes in Pulmonary Embolism

Clinical and Applied Thrombosis/Hemostasis, 2022
Introduction The pathophysiology of pulmonary embolism (PE) represents complex, multifactorial processes involving blood cells, vascular endothelium, and the activation of inflammatory pathways.
Iman Darwish B.S., Jawed Fareed PhD, Yevgeniy Brailovsky D.O., Debra Hoppensteadt PhD, Brett Slajus M.P.H., Emily Bontekoe B.S., Frank De Stefano B.S., Trent Reed D.O., Amir Darki MSc., M.D.   +8 more
doaj   +1 more source

CD34 Is a Ligand for Vascular Selectins on Human Hematopoietic Stem/Progenitor Cells

, 2015
The cell surface glycoprotein CD34 is widely recognized as a marker of hematopoietic stem/progenitor cells (HSPCs), but its physiological role on HSPCs remains elusive. Although CD34 is well recognized for mediating homing of L-selectin+ naïve T cells to
Abu Samra, Dina Bashir Kamil
core   +1 more source

Regulation of T Cell Trafficking by Enzymatic Synthesis of O-Glycans

Frontiers in Immunology, 2017
Selectins constitute a family of oligosaccharide binding proteins that play critical roles in regulating the trafficking of leukocytes. In T cells, L-selectin (CD62L) controls the capacity for naive and memory T cells to actively survey peripheral lymph ...
Samuel J. Hobbs, Jeffrey C. Nolz, Jeffrey C. Nolz, Jeffrey C. Nolz   +3 more
doaj   +1 more source

Massive expansion of P-selectin genes in two Venerida species, Sinonovacula constricta and Mercenaria mercenaria: evidence from comparative genomics of Bivalvia

BMC Genomics, 2022
Background P-selectin is a molecule participating in the inflammatory response through mediating cellular adhesion and essential for wound repair. However, studies regarding P-selectin in Bivalvia are rare. This study identified 90 P-selectin genes among
Yuanfeng Xu, Xumeng Dong, Shuonan Ma, Cheng Luo, Jilin Xu   +4 more
doaj   +1 more source

Sepsis: emerging role of nitric oxide and selectins [PDF]

Clinics, 2006
Sepsis-a state of systemic bacterial infection-often leads to multiorgan failure and is associated with high mortality despite the recent advances achieved in intensive care treatment.
Abhijit Chandra, Perenlei Enkhbaatar, Yoshimitshu Nakano, Lillian D Traber, Daniel L. Traber   +4 more
doaj   +1 more source

E- and p-selectins are essential for repopulation of chronic myelogenous and chronic eosinophilic leukemias in a scid mouse xenograft model. [PDF]

PLoS ONE, 2013
In chronic myelogenous (CML) and chronic eosinophilic leukemia (CEL), neoplastic cells spread via the circulation into various extramedullary organs. As E- and P-selectin constitute the starting point for the leucocyte adhesion/invasion cascade, and CEL ...
Daniel Wicklein, Anna Schmidt, Vera Labitzky, Sebastian Ullrich, Peter Valent, Udo Schumacher   +5 more
doaj   +1 more source