Results 31 to 40 of about 2,027 (239)
E-selectin antagonists: fragment-based drug discovery and lead optimization by NMR and BIAcore [PDF]
, 2012 The inflammatory response consists of a well-defined and regulated multi-step cascade leading to extravasation of leukocytes from the blood to sites of inflammation. The transmigration of leukocytes is initiated by their interaction with the endothelium,
Weckerle, Céline
core +1 more source
Constitutive expression of E-and P-selectin cognate ligands in human endothelial cells
Mediators of Inflammation, 1998 On human endothelial cells from umbilical cord (HUVEC) are present, in addition to E-and P-selectins, their cognate ligands. Differently from selectins, the ligand expression is constitutive and not modulated by interleukin-1β . Such ligands appear to be
C. Palma +4 more
doaj +1 more source
Inflammatory Mechanisms Contributing to Endothelial Dysfunction
Biomedicines, 2021 Maintenance of endothelial cell integrity is an important component of human health and disease since the endothelium can perform various functions including regulation of vascular tone, control of hemostasis and thrombosis, cellular adhesion, smooth ...
Panagiotis Theofilis +6 more
doaj +1 more source
Blood, 2015 In this issue of Blood , [Etulain et al][1] have added to the knowledge of neutrophil extracellular traps (NETs) by defining the mechanisms involved in platelet-triggered NET formation.[1][2] NETs have been the subject of intense investigation since their description over a decade ago.[2][3]
openaire +2 more sources
Adhesion molecules in Wilms tumor (part I) [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2003 Adhesion molekues are glicoprotees which have extracellular, transmembranous and intracytoplasmatic part. They show their basic role is in cell interaction in the tissue on one side and between cells and matrix on the other side.
Basta-Jovanović Gordana M. +2 more
doaj +1 more source
The influence of tobacco smoking on adhesion molecule profiles
Tobacco Induced Diseases, 2002 Sequential interactions between several adhesion molecules and their ligands regulate lymphocyte circulation and leukocyte recruitment to inflammatory foci. Adhesion molecules are, therefore, central and critical components of the immune and inflammatory
DA Scott, RM Palmer
doaj +1 more source
Leukocyte adhesion: Two selectins converge on sulphate [PDF]
, 1996 Selectins mediate the attachment of leukocytes to endothelial cells and to platelets under conditions of blood flow.
Rosen, Steven D, Bertozzi, Carolyn R
core +1 more source
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
Frontiers in Medicine, 2017 The historical focus on protein–protein interactions in biological systems, at the expense of attention given to interactions between other classes of molecules, has overlooked important and clinically relevant processes and points of potential clinical ...
Jeremy A. O’Sullivan +2 more
doaj +1 more source
Systematic Review and Meta-Analysis of the Effect of Statins on Circulating E-Selectin, L-Selectin, and P-Selectin [PDF]
Biomedicines, 2021 The pleiotropic effects of statins might involve preventing inflammatory cell adhesion to the endothelium, which is a critical step in the pathogenesis of atherosclerosis. We conducted a systematic review and meta-analysis of the effects of statins on the circulating cell adhesion molecules E-Selectin, L-Selectin, and P-Selectin.
Angelo Zinellu, Arduino A. Mangoni
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