Results 51 to 60 of about 24,758 (269)

Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]

, 2004
Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Abdi R, Anders HJ, Anders HJ, Anders HJ, Bruhl H, Burne-Taney MJ, Feng L, Fituri O, Fujinaka H, Garcia GE, Grone HJ, Keane MP, Mack M, Miura M, Murphy PM, Nath KA, Perez de Lema G, Rollins BJ, Romagnani P, Segerer S, Segerer S, Segerer S, Tang WW, Taub DD, Tesch GH, Tokuda A, Topham PS, Vielhauer V, Vielhauer V, Wada T, Wang Y, Wenzel U, Wu X, Wu X, Zernecke A   +34 more
core   +1 more source

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Lectin ligands: New insights into their conformations and their dynamic behavior and the discovery of conformer selection by lectins [PDF]

, 1998
The mysteries of the functions of complex glycoconjugates have enthralled scientists over decades. Theoretical considerations have ascribed an enormous capacity to store information to oligosaccharides, In the interplay with lectins sugar-code words of ...
Bovin, N. V., Burchert, M., Frank, M., Gabius, Hans-Joachim, Gilleron, M., Kaltner, Herbert, Kayser, G., Kozár, T., Lieth, Claus-Wilhelm von der, Siebert, H. C., Tajkhorshid, Emad, Vliegenthart, JFG   +11 more
core   +7 more sources

The engagement of selectins and their ligands in colorectal cancer liver metastases [PDF]

, 2010
The colonization of the liver by colorectal cancer (CRC) cells is a complicated process which includes many stages, until macrometastases occur. The entrapment of malignant cells within the hepatic sinusoids and their interactions with resident non ...
Alves, Antoine, Aoki, Asai, Aychek, Ben-David, Bilzer, Bird, Blixt, Borsig, Borsig, Borsig, Braet, Bresalier, Brooks, Burdick, Burdick, Cho, Coppola, Dabrowska, Dernedde, Di Bella, Doebis, Dymicka-Piekarska, Fritzsche, Gangopadhyay, Garcia, Gout, Haier, Haier, Hakomori, Hanley, Hanley, Haraldsen, Hauser, He, Hu, Huang, Irimura, Ito, Jadhav, Klopocki, Kneuer, Knittel, Koike, Kudo, Kuhn, Laferriere, Laferriere, Lin, Liu, Malagolini, Man, Mannori, Matsumoto, Mayr, McCarty, McCarty, McLoughlin, McMillan, Mejias-Luque, Meyer, Minami, Mollicone, Muinelo-Romay, Nakamori, Nanashima, Napier, Ngan, Niers, Nihei, Opolski, Peeters, Peng, Petretti, Petzelbauer, Ragupathi, Romano, Rudmik, Sackstein, Sato, Sawada, Schluter, Sepp, Shirota, Sierko, Silverman, Sneath, Sousou, Sousou, Springer, Stevenson, Streit, Sturm, Subramaniam, Subramaniam, Subramaniam, Takada, Taura, Thomas, Thomas, Tremblay, Tremblay, Ugorski, Uner, Vekemans, Voura, Wagnerova, Wang, Wei, Wiese, Wilkins, Witz, Witz, Yamada, Yamaguchi, Yamane, Ye, Zarbock, Zhang, Zhang, Zipin   +121 more
core   +1 more source

Macrophage Membrane‐Cloaked, ROS‐Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome

Advanced Healthcare Materials, EarlyView.
The synthesis process of MM@PCD@QNPs and its potential mechanism for treating PCOS. (A) Assembly steps of MM@PCD@QNPs. (B) Synthesis and decomposition of MM@PCD@QNPs. (C) Potential therapeutic mechanisms of MM@PCD@QNPs for PCOS. PCD, PABP conjugated with DEX polymer; QUR, quercetin; CDI, N, N′‐carbonyldiimidazole; DEX, dextran; PABP, 4‐(hydroxymethyl ...
Wenzhu Li, Yu Guan, Nan Song, Feng Zhang, Zhimin Deng, Tailang Yin, Yanbing Yang, João Conde, Wenyi Jin, Zhinang Yin   +9 more
wiley   +1 more source

Association between Endothelial Selectin (E-selectin) gene polymorphisms and E-selectin level with visceral leishmaniais, in an ARMS-PCR based study [PDF]

, 2008
Background: In the visceral leishmaniasis (VL), parasites reside in reticuluendothelial system, mainly in macrophages. Endothelial Selectin (E-selectin) might play an important role in leukocyte-endothelium interactions and inflammatory cell recruitment.
Bazmani, A., Fallah, M., Hajilooi, M., Mazloumi Gavgani, A., Taherkhani, H.   +4 more
core  

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Selectin’ for NETs [PDF]

Blood, 2015
In this issue of Blood , [Etulain et al][1] have added to the knowledge of neutrophil extracellular traps (NETs) by defining the mechanisms involved in platelet-triggered NET formation.[1][2] NETs have been the subject of intense investigation since their description over a decade ago.[2][3]
openaire   +2 more sources

Combining Genome Wide Association Studies and Differential Gene Expression Data Analyses Identifies Candidate Genes Affecting Mastitis Caused by Two Different Pathogens in the Dairy Cow [PDF]

, 2015
Mastitis is a costly disease which hampers the dairy industry. Inflammation of the mammary gland is commonly caused by bacterial infection, mainly Escherichia coli, Streptococcus uberis and Staphylococcus aureus.
Chen, X, Cheng, Z R, Wathes, D C, Werling, D, Zhang, S   +4 more
core   +3 more sources

Cap‐oPMN: Oral Inflammatory Load Quantification Using Capillary Microfluidics and Automated Image Processing

Advanced Materials Technologies, EarlyView.
ABSTRACT Quantifying oral polymorphonuclear neutrophils (oPMNs) is a clinically validated approach for assessing periodontal inflammation. However, current methods, such as manual hemocytometry and flow cytometry, are time‐consuming (>3 h), require invasive sampling, and depend on staining and complex instrumentation, making them unsuitable for point ...
Mohsen Hassani, Azam Zare, Fatemeh Soheili, S. M. Mahdi H. Daneshvar, Mahdi Amrollahi Biouki, Yasaman Tahernezhad, Chunxiang Sun, Michael Glogauer, Ebrahim Ghafar‐Zadeh, Amir Sanati‐Nezhad   +9 more
wiley   +1 more source