Results 61 to 70 of about 2,027 (239)

The association of cell adhesion molecules and selectins (VCAM-1, ICAM-1, E-selectin, L-selectin, and P-selectin) with microvascular complications in patients with type 2 diabetes: A follow-up study

Frontiers in Endocrinology, 2023
ObjectiveChronic hyperglycemia induces pathogenic changes in the vascular endothelium and leads to the development of microvascular complications in patients with type 2 diabetes mellitus.
Khalid Siddiqui, Teena P. George, Muhammad Mujammami, Muhammad Mujammami, Muhammad Mujammami, Arthur Isnani, Assim A. Alfadda, Assim A. Alfadda, Assim A. Alfadda   +8 more
doaj   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Importance of donor- and recipient-derived selectins in cardiac allograft rejection

, 2007
The selectins expressed on activated endothelial cells (E- and P-selectin), leukocytes (L-selectin), and platelets (P-selectin) play crucial roles in the rolling and tethering of leukocytes.
T. Ito, O. Sobolev, T. Ueno, P. Fiorina, A. Izawa, R. Abdi, K. Tanaka, R. O. Hynes, M. Takahashi, R. N. Smith, U. Ikeda, M. Jurewicz   +11 more
core   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

Synthesis of multivalent carbohydrate mimetics with aminopolyol end groups and their evaluation as L-selectin inhibitors

Beilstein Journal of Organic Chemistry, 2015
In this article a series of divalent and trivalent carbohydrate mimetics on the basis of an enantiopure aminopyran and of serinol is described. These aminopolyols are connected by amide bonds to carboxylic acid derived spacer units either by Schotten ...
Joana Salta, Jens Dernedde, Hans-Ulrich Reissig   +2 more
doaj   +1 more source

Derivation of Cinnamon Blocks Leukocyte Attachment by Interacting with Sialosides. [PDF]

PLoS ONE, 2015
Molecules derived from cinnamon have demonstrated diverse pharmacological activities against infectious pathogens, diabetes and inflammatory diseases.
Wei-Ling Lin, Shih-Yun Guu, Chan-Chuan Tsai, Ekambaranellore Prakash, Mohan Viswaraman, Hsing-Bao Chen, Chuan-Fa Chang   +6 more
doaj   +1 more source

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

Advanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler   +13 more
wiley   +1 more source

Mediators of intercellular interactions and histological signs of chronic viral liver disease

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2014
Aim of investigation. To establish interrelation of intercellular interaction mediators with histological changes at chronic viral liver disease.Material and methods.
P. V. Koroy, A. V. Yagoda, G. I. Gilyazova, I. S. Mukhoramova   +3 more
doaj  

Early in vitro results indicate that de-O-acetylated sialic acids increase Selectin binding in cancers

Frontiers in Oncology
Cancers utilize a simple glycan, Sialic Acid, to engage in metastatic processes via the Sialic acid (Sia) -Selectin pathway. Selectins recognize and bind to sialylated substrates, resulting in adhesion, migration, and extravasation, however, how ...
Kakali Das, Megan Schulte, Megan Gerhart, Hala Bayoumi, Delayna Paulson, Darci M. Fink, Colin Parrish, Rachel Willand-Charnley   +7 more
doaj   +1 more source

Thrombo-hemorrhagic liability in children with congenital heart diseases

Hematology/Oncology and Stem Cell Therapy, 2018
Background: The precise mechanisms of the increased incidence of hemostatic abnormalities in congenital heart disease (CHD) have not been determined. The aim of the study was to evaluate some indicators of activation of platelets and vascular endothelial
Shebl Said Shebl, Walid Ahmed Naguib El-shehaby, Yasmin Shebl Said, Amira Hamed Darwish, Nabeh Helal Elfadaly, Eman Amer   +5 more
doaj   +1 more source