Results 81 to 90 of about 24,758 (269)

A high‐fat diet with vitamin D and propylthiouracil produces a pro‐atherogenic phenotype in rats

Animal Models and Experimental Medicine, EarlyView.
Male Sprague–Dawley rats received a cholesterol‐rich high‐fat diet supplemented with vitamin D and propylthiouracil for 11 weeks. The model induced dyslipidemia (increased total cholesterol/low‐density lipoprotein, decreased triglycerides), inflammation (increased interleukin‐6 and serum amyloid A), hypercalcemia, and reduced circulating endothelial ...
Angélique Lewies, Vitaris Kodogo, Johannes Frederik Wentzel, Francis Edwin Smit   +3 more
wiley   +1 more source

Human T cell glycosylation and implications on immune therapy for cancer [PDF]

, 2020
Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome.
Callewaert, Nico, De Bousser, Elien, Festjens, Nele, Meuris, Leander   +3 more
core   +1 more source

USB1 deficiency disrupts neutrophil maturation via RNA dysregulation independent of global pre‐mRNA splicing

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the essential role of USB1 in neutrophil maturation. In normal myeloid cells, USB1 acts as an RNA exonuclease, trimming RNA tails to maintain proper RNA network function, which supports the differentiation of myeloid progenitor cells into mature neutrophils.
Hang Li, Guiying Shi, Jiaming Tang, Yiying Huang, Jie Wang, Xuepei Lei, Lin Bai   +6 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Triple selectin knockout (ELP-/-) mice fail to develop OVA-induced acute asthma phenotype

Journal of Inflammation, 2011
Objective The recruitment of leukocytes from circulation to sites of inflammation requires several families of adhesion molecules among which are selectins expressed on a variety of cells.
Banerjee Ena
doaj   +1 more source

A novel method to analyze leukocyte rolling behavior in vivo [PDF]

, 2004
Leukocyte endothelial cell interaction is a fundamentally important process in many disease states. Current methods to analyze such interactions include the parallel-plate flow chamber and intravital microscopy.
EC Butcher, U Jung, K Ley, DS Milstone, EJ Kunkel, SB Forlow, JV Stein, H Xu, L Sikora, MH Grayson, EJ Kunkel, U Jung, JJ Campbell, GE Rainger, RE Gerszten, JL Dunne, JL Dunne, SI Simon, JV Forrester, K Ley, ZM Ding, H Lu, S Baez, J Tang, N Ray, ST Acton, KE Norman   +26 more
core   +2 more sources

A Cooperative Release of Mitochondrial DNA From Platelets and Neutrophils Drives an Interferon Signature in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Mitochondria are organelles with a hypomethylated circular genome. Mitochondrial DNA (mtDNA) in the systemic circulation has been implicated in inflammation. This study investigates the role of circulating DNA in systemic sclerosis (SSc) and the cellular mechanisms governing its release.
Stavros Giaglis, André N. Tiaden, Simone Häner‐Massimi, Diego Kyburz, Cedric André, Anton Glück, Enrico Ferrero, Stuart Hawtin, Tobias Junt, Ulrich A. Walker   +9 more
wiley   +1 more source

Extravasation of leukocytes in comparison to tumor cells [PDF]

, 2008
The multi-step process of the emigration of cells from the blood stream through the vascular endothelium into the tissue has been termed extravasation. The extravasation of leukocytes is fairly well characterized down to the molecular level, and has been
Carina Strell, Frank Entschladen, S Paget, F Balkwill, A Muller, F Entschladen, T Osada, WC Aird, JG Wagner, CM Doerschuk, CM Doerschuk, CM Doerschuk, GP Downey, WC Aird, JP Girard, M Miyasaka, L Liu, LA Lasky, S Baumheter, E Umemoto, S Hemmerich, H Kawashima, SD Rosen, CS Elangbam, SR Barthel, KM Schweitzer, R Sackstein, C Strell, DB Ivanov, G Christofori, S Garrido-Urbani, WH Su, FL Miles, MM Burdick, WD Hanley, SL Napier, CJ Dimitroff, S Aigner, SN Thomas, J Qi, L Borsig, YJ Kim, H Laubli, AD Luster, M Baggiolini, Y Tanaka, F Entschladen, RP McEver, K Dib, SC Fagerholm, K Ley, JJ Campbell, GF Debes, HE Broxmeyer, F Balkwill, T Kakinuma, J Vandercappellen, AR Cardones, WL Jamieson, SA Shulby, TL Drell, F Entschladen, S Kapper, D Palm, BH Luo, G Constantin, C Laudanna, MA Arnaout, T Kinashi, KL Wegener, GC Ibbotson, MI Cybulsky, MI Cybulsky, RM Rao, AM Montgomery, M Ruppert, FT Liu, VL Thijssen, RC Hughes, KK Hoyer, BN Stillman, GA Rabinovich, N Clausse, R Lotan, D Cooper, M La, LV Norling, GA Rabinovich, E Ryschich, J Nieminen, R Matsumoto, C Zhu, A Garofalo, H Okahara, EB Voura, P Nangia-Makker, VV Glinsky, VV Glinsky, SK Khaldoyanidi, I Fonseca, GF Springer, LG Yu, LG Yu, V Sarafian, B Petri, WA Muller, WA Muller, ME Berman, IN Bird, D Vestweber, O Lou, MG Bixel, AR Schenkel, K Ebnet, I Martin-Padura, G Ostermann, B Engelhardt, MP Arrate, D Leppert, P Friedl, AB Al-Mehdi, C Heyder, B Brandt   +122 more
core   +2 more sources

Identifying systemic lupus erythematosus from serum proteomic profiles using machine learning and genetic risk stratification

Arthritis &Rheumatology, Accepted Article.
Objectives Proteome‐wide risk models for lupus remain underexplored. We developed classification models to identify lupus from serum proteomic profiles. Methods Lupus patients and individuals with other autoimmune diseases in the UK Biobank were included.
Mehmet Hocaoǧlu, Jishnu Das, Amr H Sawalha   +2 more
wiley   +1 more source

Mimetics of Sialyl Lewisx: The Pre-Organization of the Carboxylic Acid is Essential for Binding to Selectins

CHIMIA, 2007
Selectins play a key role in leukocyte trafficking during the inflammatory response of the organism, i.e. the recruitment and extravasation of leukocytes from the blood stream into inflamed tissue.
Alexander Titz, Beat Ernst
doaj   +1 more source