Results 91 to 100 of about 14,056 (288)

Platelets, selectins, and the control of tumor metastasis

, 2015
The significant role of platelets and P-selectin in assisting tumor cell metastasis to the lungs has been frequently reported and reviewed. However, evidence recently has come to light on other pro-metastatic mechanisms of platelets beyond that of tumor ...
Parish, Christopher, Coupland, Lucy, Chong, Beng   +2 more
core   +1 more source

Circulating monocyte partitioning and its alteration in hematological chronic neoplasms

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Circulating monocyte partitioning refers to the relative quantification of the three main monocyte subsets in the peripheral blood, namely classical (cMo), intermediate (iMo), and non‐classical (ncMo) monocytes, as assessed by flow cytometry, a new nomenclature described 15 years ago.
Sihem Tarfi, Dorothée Selimoglu‐Buet, Ivan Sloma, Orianne Wagner‐Ballon, on behalf of the French group CytHem‐LMMC   +4 more
wiley   +1 more source

PSGL-1, ADAM8, and selectins as potential biomarkers in the diagnostic process of systemic lupus erythematosus and systemic sclerosis: an observational study

Frontiers in Immunology
BackgroundEarly diagnosis and treatment of Systemic lupus erythematosus (SLE) and Systemic sclerosis (SSc) present significant challenges for clinicians.
Esther San Antonio, Javier Silván, Javier Sevilla-Montero, Elena González-Sánchez, Antonio Muñoz-Callejas, Antonio Muñoz-Callejas, Inés Sánchez-Abad, Alejandra Ramos-Manzano, Alejandra Ramos-Manzano, Cecilia Muñoz-Calleja, Cecilia Muñoz-Calleja, Isidoro González-Álvaro, Eva G. Tomero, Javier García-Pérez, Rosario García-Vicuña, Rosario García-Vicuña, Esther F. Vicente-Rabaneda, Esther F. Vicente-Rabaneda, Santos Castañeda, Ana Urzainqui   +19 more
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

Recognition of consensus CHO structure in ligands for selectins by novel antibody against sialyl Lewis X

, 1995
The selectins (L, E, and P) play an important role in the earliest events of the inflammatory response, leading to the “rolling” phenomenon. All selectins react with sialyl Lewis X (SLex) in vitro, possibly suggesting that their ligands have a consensus
M. Suematsu, S. Toyoshima, M. Homma, K. Tezuka, T. Tamatani, N. Hanzawa, Y. Ishimura, R. Kannagi, T. Tsuji   +8 more
core   +1 more source

Natural killer cells require selectins for suppression of subcutaneous tumors [PDF]

, 2009
Natural killer (NK) cells recognize and destroy cancer cells through a variety of mechanisms. They may also modulate the adaptive immune response to cancer by interacting with dendritic cells and T cells. Although NK cells play an important role in tumor
Richard O. Hynes, Sobolev, O, Patrick Stern, Stern, P, Lacy-Hulbert, Adam, Adam Lacy-Hulbert, Olga Sobolev, Hynes, Richard O   +7 more
core   +1 more source

How E‑, L‑, and P‑Selectins Bind to sLe^x and PSGL-1: A Quantification of Critical Residue Interactions

, 2023
Selectins and their ability to interact with specific ligands are a cornerstone in cell communication. Over the last three decades, a considerable wealth of experimental and molecular modeling insights into their structure and modus operandi were ...
Igor Tvaroška, Pavel Šmak (16639852), Igor Tvaroška (1355514), Vladimir Sladek (6033674), Pavel Šmak, Vladimir Sladek   +5 more
core   +1 more source

Photodynamic Biomimetic Nanoparticles Accelerate Tumor Vascular Normalization Initiation

Exploration, EarlyView.
Platelet‐mimetic IA@PM integrates apatinib‐driven vascular normalization with ICG‐mediated photodynamic therapy, creating a self‐amplifying vascular normalization therapy (VNT)–photodynamic therapy (PDT) cycle that accelerates the onset of the vascular normalization window and potentiates antitumor treatment.
Yufei Liu, Changheng Xie, Yanfeng Huang, Ting Wang, Shi Du, Hui Xiong, Jing Yao   +6 more
wiley   +1 more source

Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis

Frontiers in Immunology, 2019
Cell-cell interactions and cell adhesion are key mediators of cancer progression and facilitate hallmarks of cancer including immune evasion and metastatic dissemination.
Heinz Läubli, Lubor Borsig, Lubor Borsig   +2 more
doaj   +1 more source