Results 11 to 20 of about 12,701 (240)
Integrin alpha-V is an important driver in pancreatic adenocarcinoma progression
Journal of Experimental & Clinical Cancer Research, 2021 Background Mesothelial E- and P-selectins substantially mediate the intraperitoneal spread of Pancreatic ductal adenocarcinoma (PDA) cells in xenograft models.
Marius Kemper +14 more
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Терапевтический архив, 2021 Inflammatory diseases of the pancreas can range from acute to acute recurrent and chronic pancreatitis. With the improvement of laboratory diagnostics in the 21st century, the mechanisms of the pro-inflammatory and anti-inflammatory role of tight ...
Vadim A. Akhmedov, Olga V. Gaus
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Targeting cancer-associated glycans as a therapeutic strategy in leukemia
All Life, 2022 Unlike cytotoxic chemotherapy, cancer immunotherapy offers targeted therapies that exploit the effector mechanisms of the immune system to combat cancer.
Ashraf Abdullah Saad
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Targeting selectins and selectin ligands in inflammation and cancer [PDF]
Expert Opinion on Therapeutic Targets, 2007 Inflammation and cancer metastasis are associated with extravasation of leukocytes or tumor cells from blood into tissue. Such movement is believed to follow a coordinated and sequential molecular cascade initiated, in part, by the three members of the selectin family of carbohydrate-binding proteins: E-selectin (CD62E), L-selectin (CD62L) and P ...
Steven R, Barthel +3 more
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Selectin and selectin ligand binding: a bittersweet attraction [PDF]
Journal of Clinical Investigation, 2003 Inhibition of leukocyte migration into target organs has long been an attractive, though challenging, basis for anti-inflammatory strategies. However, to date, the manipulation of leukocyte rolling along blood vessels has not yielded successful new therapies.
Thomas M, Zollner, Khusru, Asadullah
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Perinatal Inflammation: Could Partial Blocking of Cell Adhesion Molecule Function Be a Solution?
Children, 2021 In spite of the great advances made in recent years in prenatal and perinatal medicine, inflammation can still frequently result in injury to vital organs and often constitutes a major cause of morbidity.
Nikolaos Vrachnis +9 more
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Frontiers in Medicine, 2020 Selectins [endothelial (E), platelet (P), and leucocytes (L)] are a class of cell adhesion molecules, stimulated in response to inflammation. Pre-eclampsia is characterized by inflammation, and angiotensin II is pro-inflammatory.
Hiten D. Mistry +5 more
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MRI Contrast Agents in Glycobiology
Molecules, 2022 Molecular recognition involving glycoprotein-mediated interactions is ubiquitous in both normal and pathological natural processes. Therefore, visualization of these interactions and the extent of expression of the sugars is a challenge in medical ...
Carlos F. G. C. Geraldes, Joop A. Peters
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Role of endothelial cells in graft-versus-host disease
Frontiers in Immunology, 2022 To date, the only curative treatment for high-risk or refractory hematologic malignancies non-responsive to standard chemotherapy is allogeneic hematopoietic transplantation (allo-HCT).
Lotus Neidemire-Colley +10 more
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Constitutive expression of E-and P-selectin cognate ligands in human endothelial cells
Mediators of Inflammation, 1998 On human endothelial cells from umbilical cord (HUVEC) are present, in addition to E-and P-selectins, their cognate ligands. Differently from selectins, the ligand expression is constitutive and not modulated by interleukin-1β . Such ligands appear to be
C. Palma +4 more
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