Lewis X antigen mediates adhesion of human breast carcinoma cells to activated endothelium. Possible involvement of the endothelial scavenger receptor C-Type lectin [PDF]
, 2007 Lewis x (Lex, CD15), also known as SSEA-1 (stage specific embryonic antigen-1), is a trisaccharide with the structure Galβ(1–4)Fucα(1–3)GlcNAc, which is expressed on glycoconjugates in human polymorphonuclear granulocytes and various tumors such as colon
A Hittelet +51 more
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Constitutive expression of E-and P-selectin cognate ligands in human endothelial cells
Mediators of Inflammation, 1998 On human endothelial cells from umbilical cord (HUVEC) are present, in addition to E-and P-selectins, their cognate ligands. Differently from selectins, the ligand expression is constitutive and not modulated by interleukin-1β . Such ligands appear to be
C. Palma +4 more
doaj +1 more source
Inflammatory Mechanisms Contributing to Endothelial Dysfunction
Biomedicines, 2021 Maintenance of endothelial cell integrity is an important component of human health and disease since the endothelium can perform various functions including regulation of vascular tone, control of hemostasis and thrombosis, cellular adhesion, smooth ...
Panagiotis Theofilis +6 more
doaj +1 more source
Role of P-selectin in platelet sequestration in pulmonary capillaries during endotoxemia [PDF]
, 2006 Background: There is growing evidence that platelets accumulate in the lung and contribute to the pathogenesis of acute lung injury during endotoxemia.
Alwin Eduard Goetz +37 more
core +1 more source
Evaluation of L-selectin expression and assessment of protein tyrosine phosphorylation in bovine polymorphonuclear neutrophil leukocytes around parturition. [PDF]
, 2002 Impaired polymorphonuclear neutrophil leukocyte (PMN) function around parturition has been associated with increased clinical mastitis in dairy cows. Rolling and attachment of PMN to the endothelium is the first step in the recruitment process and is ...
Burvenich, Christian +6 more
core +1 more source
Human amniotic fluid glycoproteins expressing sialyl Lewis carbohydrate antigens stimulate progesterone production in human trophoblasts in vitro [PDF]
, 2004 Background: Progesterone is thought to mediate immune modulator effects by regulating uterine responsiveness. The aim of the study was to clarify the effect of transferrin and glycodelin A (former name PP14) as sialyl Lewis X-expressing glycoproteins on ...
Annett Streu +24 more
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Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
In Vivo Fluorescence Imaging of E-Selectin: Quantitative Detection of Endothelial Activation in Arthritis [PDF]
, 2010 Rheumatoid arthritis (RA) is a chronic progressive systemic inflammatory disease, characterized by synovial inflammation and localized destruction of cartilage and bone.
Gompels, Luke, Gompels, Luke
core +1 more source
Adhesion molecules in Wilms tumor (part I) [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2003 Adhesion molekues are glicoprotees which have extracellular, transmembranous and intracytoplasmatic part. They show their basic role is in cell interaction in the tissue on one side and between cells and matrix on the other side.
Basta-Jovanović Gordana M. +2 more
doaj +1 more source
Selectin and selectin ligand binding: a bittersweet attraction [PDF]
Journal of Clinical Investigation, 2003 Inhibition of leukocyte migration into target organs has long been an attractive, though challenging, basis for anti-inflammatory strategies. However, to date, the manipulation of leukocyte rolling along blood vessels has not yielded successful new therapies.
Thomas M, Zollner, Khusru, Asadullah
openaire +2 more sources