Results 21 to 30 of about 14,056 (288)
Potential Roles of Selectins in Periodontal Diseases and Associated Systemic Diseases: Could They Be Targets for Immunotherapy? [PDF]
, 2022 Periodontal diseases are predisposing factors to the development of many systemic disorders, which is often initiated via leukocyte infiltration and vascular inflammation. These diseases could significantly affect human health and quality of life. Hence,
Lee, Learn-Han +15 more
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Targeting Selectins Mediated Biological Activities With Multivalent Probes
Frontiers in Chemistry, 2021 Selectins are type-I transmembrane glycoproteins that are ubiquitously expressed on activated platelets, endothelial cells, and leukocytes. They bind to cell surface glycoproteins and extracellular matrix ligands, regulate the rolling of leukocytes in ...
Deepak Ganesh +4 more
doaj +1 more source
Role of endothelial cells in graft-versus-host disease
Frontiers in Immunology, 2022 To date, the only curative treatment for high-risk or refractory hematologic malignancies non-responsive to standard chemotherapy is allogeneic hematopoietic transplantation (allo-HCT).
Lotus Neidemire-Colley +10 more
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Selectins promote tumor metastasis [PDF]
, 2010 Cancer metastasis is facilitated by cell-cell interactions between cancer cells and endothelial cells in distant tissues. In addition, cancer cell interactions with platelets and leukocytes contribute to cancer cell adhesion, extravasation, and the ...
Läubli, H +3 more
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Animal lectins as cell adhesion molecules [PDF]
, 1998 Protein-carbohydrate interaction is exploited in cell adhesion mechanisms besides the recognition of peptide motifs. The sugar code thus significantly contributes to the intriguing specificity of cellular selection of binding partners.
Kaltner, H., Stierstorfer, B.
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E-selectin antagonists: fragment-based drug discovery and lead optimization by NMR and BIAcore [PDF]
, 2012 The inflammatory response consists of a well-defined and regulated multi-step cascade leading to extravasation of leukocytes from the blood to sites of inflammation. The transmigration of leukocytes is initiated by their interaction with the endothelium,
Weckerle, Céline
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Constitutive expression of E-and P-selectin cognate ligands in human endothelial cells
Mediators of Inflammation, 1998 On human endothelial cells from umbilical cord (HUVEC) are present, in addition to E-and P-selectins, their cognate ligands. Differently from selectins, the ligand expression is constitutive and not modulated by interleukin-1β . Such ligands appear to be
C. Palma +4 more
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Inflammatory Mechanisms Contributing to Endothelial Dysfunction
Biomedicines, 2021 Maintenance of endothelial cell integrity is an important component of human health and disease since the endothelium can perform various functions including regulation of vascular tone, control of hemostasis and thrombosis, cellular adhesion, smooth ...
Panagiotis Theofilis +6 more
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Blood, 2015 In this issue of Blood , [Etulain et al][1] have added to the knowledge of neutrophil extracellular traps (NETs) by defining the mechanisms involved in platelet-triggered NET formation.[1][2] NETs have been the subject of intense investigation since their description over a decade ago.[2][3]
openaire +2 more sources
Adhesion molecules in Wilms tumor (part I) [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2003 Adhesion molekues are glicoprotees which have extracellular, transmembranous and intracytoplasmatic part. They show their basic role is in cell interaction in the tissue on one side and between cells and matrix on the other side.
Basta-Jovanović Gordana M. +2 more
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