Results 21 to 30 of about 2,027 (239)
Integrin alpha-V is an important driver in pancreatic adenocarcinoma progression
Journal of Experimental & Clinical Cancer Research, 2021 Background Mesothelial E- and P-selectins substantially mediate the intraperitoneal spread of Pancreatic ductal adenocarcinoma (PDA) cells in xenograft models.
Marius Kemper +14 more
doaj +1 more source
Терапевтический архив, 2021 Inflammatory diseases of the pancreas can range from acute to acute recurrent and chronic pancreatitis. With the improvement of laboratory diagnostics in the 21st century, the mechanisms of the pro-inflammatory and anti-inflammatory role of tight ...
Vadim A. Akhmedov, Olga V. Gaus
doaj +1 more source
Targeting cancer-associated glycans as a therapeutic strategy in leukemia
All Life, 2022 Unlike cytotoxic chemotherapy, cancer immunotherapy offers targeted therapies that exploit the effector mechanisms of the immune system to combat cancer.
Ashraf Abdullah Saad
doaj +1 more source
Selectin and selectin ligand binding: a bittersweet attraction [PDF]
Journal of Clinical Investigation, 2003 Inhibition of leukocyte migration into target organs has long been an attractive, though challenging, basis for anti-inflammatory strategies. However, to date, the manipulation of leukocyte rolling along blood vessels has not yielded successful new therapies.
Thomas M, Zollner, Khusru, Asadullah
openaire +2 more sources
Targeting selectins and selectin ligands in inflammation and cancer [PDF]
Expert Opinion on Therapeutic Targets, 2007 Inflammation and cancer metastasis are associated with extravasation of leukocytes or tumor cells from blood into tissue. Such movement is believed to follow a coordinated and sequential molecular cascade initiated, in part, by the three members of the selectin family of carbohydrate-binding proteins: E-selectin (CD62E), L-selectin (CD62L) and P ...
Steven R, Barthel +3 more
openaire +2 more sources
Perinatal Inflammation: Could Partial Blocking of Cell Adhesion Molecule Function Be a Solution?
Children, 2021 In spite of the great advances made in recent years in prenatal and perinatal medicine, inflammation can still frequently result in injury to vital organs and often constitutes a major cause of morbidity.
Nikolaos Vrachnis +9 more
doaj +1 more source
MRI Contrast Agents in Glycobiology
Molecules, 2022 Molecular recognition involving glycoprotein-mediated interactions is ubiquitous in both normal and pathological natural processes. Therefore, visualization of these interactions and the extent of expression of the sugars is a challenge in medical ...
Carlos F. G. C. Geraldes, Joop A. Peters
doaj +1 more source
Animal lectins as cell adhesion molecules [PDF]
, 1998 Protein-carbohydrate interaction is exploited in cell adhesion mechanisms besides the recognition of peptide motifs. The sugar code thus significantly contributes to the intriguing specificity of cellular selection of binding partners.
Kaltner, H., Stierstorfer, B.
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Role of endothelial cells in graft-versus-host disease
Frontiers in Immunology, 2022 To date, the only curative treatment for high-risk or refractory hematologic malignancies non-responsive to standard chemotherapy is allogeneic hematopoietic transplantation (allo-HCT).
Lotus Neidemire-Colley +10 more
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Selectins promote tumor metastasis [PDF]
, 2010 Cancer metastasis is facilitated by cell-cell interactions between cancer cells and endothelial cells in distant tissues. In addition, cancer cell interactions with platelets and leukocytes contribute to cancer cell adhesion, extravasation, and the ...
Läubli, H +3 more
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