Results 91 to 100 of about 49,530 (262)

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source

Detection of CD33 expression on monocyte surface is influenced by phagocytosis and temperature [PDF]

, 2019
CD33 is a myeloid-associated marker and belongs to the sialic acid-binding immunoglobulin (Ig)-like lectin (Siglec) family. Such types of receptors are highly expressed in acute myeloid leukemia, which could be used in its treatment.
Baisaeng, Nuttakorn, Boonla, Chanchai, Bäumler, Hans, Georgieva, Radostina, Kaewprayoon, Waraporn, Kloypan, Chiraphat, Smuda, Kathrin, Suwannasom, Nittiya   +7 more
core   +1 more source

BCR-Mediated Decrease of CXCR4 and CD62L in CLL – Letter [PDF]

Cancer Research, 2010
Recently, Vlad and colleagues ([1][1]) published that cross-linking of the B-cell receptor (BCR) regulates chronic lymphocytic leukemia (CLL) cell retention within lymphatic tissues by downregulation of CXCR4 chemokine receptors, l-selectins (CD62L), reduced CLL chemotaxis toward the ligand ...
Maite P. Quiroga, Jan A. Burger
openaire   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Ccl2 and Ccl3 Mediate Neutrophil Recruitment via Induction of Protein Synthesis and Generation of Lipid Mediators [PDF]

, 2009
Objective: Although the chemokines monocyte chemoattractant protein-1 (Ccl2/JE/MCP-1) and macrophage inflammatory protein-1α (Ccl3/MIP-1α) have recently been implicated in neutrophil migration, the underlying mechanisms remain largely unclear.
Berberich, Nina, Bihari, Peter, Khandoga, Alexander G., Krombach, Fritz, Lerchenberger, Max, Rehberg, Markus, Reichel, Christoph A., Zahler, Stefan   +7 more
core   +1 more source

Complex Memory T-Cell Phenotypes Revealed by Coexpression of CD62L and CCR7 [PDF]

Journal of Virology, 2005
ABSTRACT Antigen-experienced T cells have been divided into CD62L + CCR7 + central memory (T CM ) and CD62L − CCR7 −
Ufheil, Heike, Pircher, Hanspeter
openaire   +3 more sources

NIR‐Activatable Domino Cascade Catalysis Nanozyme Reactor for Multi‐Mechanism Synergistic Immunotherapy in Bladder Cancer

Advanced Science, EarlyView.
This study presents an intravesical delivery strategy of ferroptosis‐ and immunity‐inducing nanozyme‐loaded thermoresponsive hydrogels (FMCC@PNH) for enhanced bladder cancer therapy. Abstract Current intravesical therapies for bladder cancer after resection are limited by poor tissue penetration, off‐target effects, and insufficient efficacy.
Yongnan Jiang, Qingling Zhang, Yuhan Zhang, Xinlu Yu, Bo Jia, Yulong Dong, Yalong Wu, Kelong Fan, Xinquan Gu, Lei Ji, Wei Jiang, Bin Liu   +11 more
wiley   +1 more source

Limfocyty T regulatorowe z ekspresją L-selektyny u dzieci i młodzieży z przewlekłą cukrzycą typu 1 [PDF]

Pediatric Endocrinology, Diabetes and Metabolism, 2010
Wprowadzenie: Zaburzenia ilościowe i/lub jakościowe w populacji limfocytów T regulatorowych mogą odgrywać rolę w rozwoju chorób autoimmunologicznych, w tym cukrzycy typu 1. CD62L jest receptorem zasiedlania limfocytów do węzłów chłonnych. Na mysim modelu
Monika Ryba, Łukasz Hak, Katarzyna Zorena, Małgorzata Myśliwiec, Jolanta Myśliwska   +4 more
doaj  

High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection

Memorias do Instituto Oswaldo Cruz, 2006
Herein we have focused attention on major phenotypic features of peripheral blood eosinophils from chronic Schistosoma mansoni-infected patients. For this purpose, detailed immunophenotypic profiles of a range of cell surface markers were performed ...
Denise Silveira-Lemos, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Lúcia Fraga Alves Oliveira, Rodrigo Corrêa-Oliveira   +4 more
doaj   +1 more source