Results 181 to 190 of about 49,530 (262)

T‐cell exhaustion from a multiomics perspective: Differentiation mechanisms and regulatory networks in the journey from progenitor‐Exhausted T cells to terminally exhausted T cells

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
(1) Core Process: Persistent antigen, from TDLNs to TME, drives Tpex → Tex‐int → Tex‐term differentiation. (2) Multiomics Regulation: This fate transition is orchestrated by a co‐ordinated, multi‐layered molecular network. (3) Functional Outcome: Dysregulated signalling and surging co‐inhibitory receptors lock in proliferative arrest and functional ...
Tong Zhu, Xiaoyu Teng, Qinlian Jiao, Yidan Ren, Yunshan Wang, Maoxiao Feng   +5 more
wiley   +1 more source

Loss of Dmrta1 alters CD8+ T cell activation and resistance to influenza virus infection. [PDF]

Immunohorizons
Kondo H, Otsuka K, Morimoto J, Arimochi H, Tsukumo SI, Yasutomo K.   +5 more
europepmc   +1 more source

HIV-1 and SIV Infection are associated with early loss of lung interstitial CD4+ T cells and dissemination of pulmonary tuberculosis [PDF]

, 2019
et al,, Khader, Shabaana A
core   +1 more source

A Novel Murine Model of Hemophagocytic Lymphohistiocytosis‐Like Inflammation in ZNFX1 Deficiency

European Journal of Immunology, Volume 56, Issue 2, February 2026.
LCMV‐infected Znfx1‐deficient mice develop hemophagocytic lymphohistiocytosis (HLH)‐like immune dysregulation, mirroring key aspects of the immunopathology observed in ZNFX1‐deficient patients. ABSTRACT Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory syndrome characterized by persistent activation of lymphocytes and macrophages ...
Diana Tintor, Samantha Milanesi, Tommaso Marchetti, Tiziana Lorenzini, Severin Walser, Junyi Chen, Julius Köppen, Achim Weber, Ola Sabet, Jana Pachlopnik Schmid   +9 more
wiley   +1 more source

T cell priming by high avidity neoantigens in lymph nodes augments adoptive immunotherapy. [PDF]

Cancer Immunol Res
Wittling MC, Rivera Reyes AM, Wyatt MM, Cole AC, Smith AS, Rangel Rivera GO, Carmouche JH, Diatikar KG, Ruffin AT, Ware MB, Bennett FJ, Dwyer CJ, Pihl RMF, Kumaresan S, Lesinski GB, Paulos CM, Knochelmann HM.   +16 more
europepmc   +1 more source

S14 Eosinophil activation status and CD62L expression in airways disease [PDF]

COPD: inflammation and immunity, 2018
Cane, J, Waite, S, Bafadhel, M
openaire   +1 more source

Cytomegalovirus‐Based Viral Vectors Elicit Robust Systemic and Tissue‐Resident Immune Response Against SARS‐CoV‐2 Antigens

European Journal of Immunology, Volume 56, Issue 2, February 2026.
We developed murine CMV‐based viral vectors expressing SARS‐CoV‐2 spike antigen and compared immune response following intraperitoneal and intranasal delivery. Route of vaccine administration shaped antibody and CD8+ T cell response magnitude, kinetics, and tissue residency, highlighting the potential of CMV vectors for induction of protective lung ...
Maja Cokarić Brdovčak, Jelena Materljan Franki, Marko Šustić, Karmela Miklić, Magdalena Medved, Lydia Gaćina, Tina Ružić, Stipan Jonjić, Ilija Brizić, Astrid Krmpotić   +9 more
wiley   +1 more source

Constitutively Active Stat5b Expression in Dendritic Cells Enhances Treg-Mediated Elimination of Autoreactive CD8⁺ T Cells in Autoimmune Diabetes. [PDF]

Int J Mol Sci
Khongorzul P, Khan FU, Levasseur D, Gris D, Amrani A.   +4 more
europepmc   +1 more source

Distinguishing Features of ILC2s During Type 2 Immune Responses

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Group 2 innate lymphoid cells (ILC2s) are tissue‐resident cells regulated by diverse signals often emanating from surrounding nonhematopoietic cells at barrier surfaces. Their effector cytokines determine tissue homeostasis at steady state and during type 2 immunity in allergies or worm infections.
Manuel O. Jakob, Patrycja M. Forster, Christoph S. N. Klose   +2 more
wiley   +1 more source

BioWinfordMR: an online platform for comprehensive Mendelian randomization analysis. [PDF]

Front Immunol
Wang Y, Wu T, Lu X, Wang X, Xue W.
europepmc   +1 more source