Results 11 to 20 of about 49,530 (262)

Stress regulates the lymphocyte homing receptor CD62L (L-selectin) [PDF]

Arquivos de Neuro-Psiquiatria, 2003
Based on a previous study showing that panic disorder patients had increased expression of naïve phenotype lymphocytes (CD45RA+ and CD62L+), increased plasma cortisol, as well as decreased interleukin-2 (IL-2) producion, we hypothesized that changes in ...
Gisele Gus Manfro, Carlos Alexandre Netto, Mark Pollack, Kelin Maggioni Mezzomo, Frederic Preffer, Richard Kradin   +5 more
doaj   +5 more sources

CD62L expression level determines the cell fate of myeloid progenitors [PDF]

Stem Cell Reports, 2021
Hematopoietic cells differentiate through several progenitors in a hierarchical manner, and recent single-cell analyses have revealed substantial heterogeneity within each progenitor. Although common myeloid progenitors (CMPs) are defined as a multipotent cell population that can differentiate into granulocyte-monocyte progenitors (GMPs) and ...
Ito, Yusuke, Nakahara, Fumio, Kagoya, Yuki, Kurokawa, Mineo   +3 more
openaire   +2 more sources

CD62L as a Therapeutic Target in Chronic Lymphocytic Leukemia [PDF]

Clinical Cancer Research, 2013
Abstract Purpose: Despite advances in the treatment of chronic lymphocytic leukemia (CLL), the disease remains incurable with standard therapies and relapse is inevitable. A growing body of evidence indicates that alterations in the adhesion properties of neoplastic cells play a pivotal role in the development and progression of CLL.
Burgess, Melinda, Gill, Devinder, Singhania, Richa, Cheung, Catherine, Chambers, Lynne, Renyolds, Brent A, Smith, Louise, Mollee, Peter, Saunders, Nicholas, McMillan, Nigel AJ   +9 more
openaire   +3 more sources

Natalizumab treatment reduces L-selectin (CD62L) in CD4+ T cells [PDF]

Journal of Neuroinflammation, 2015
The purpose of this research was to validate the low expression of L-selectin (CD62L) in natalizumab (NTZ)-treated patients. CD62L is involved in rolling and transmigration of leukocyte cells. A correlation between CD62LCD4+ T cells low expression and progressive multifocal leukoencephalopathy (PML) development has been suggested in multiple sclerosis (
Spadaro, Michela, Caldano, Marzia, Marnetto, Fabiana, LUGARESI, ALESSANDRA, Bertolotto, Antonio   +4 more
openaire   +3 more sources

CD21 and CD62L shedding are both inducible via P2X7Rs [PDF]

International Immunology, 2006
Neutrophils and lymphocytes are recruited to sites of inflammation and require the adhesion molecule L-selectin (CD62L) for adherence to endothelial cells. Nucleotides released from activated or dying cells at sites of inflammation can mediate signaling through purinergic receptor family II, resulting in CD62L shedding.
Sarah, Sengstake, Eva-Maria, Boneberg, Harald, Illges   +2 more
openaire   +2 more sources

Changes in natural Foxp3(+)Treg but not mucosally-imprinted CD62L(neg)CD38(+)Foxp3(+)Treg in the circulation of celiac disease patients. [PDF]

PLoS ONE, 2013
BACKGROUND: Celiac disease (CD) is an intestinal inflammation driven by gluten-reactive CD4(+) T cells. Due to lack of selective markers it has not been determined whether defects in inducible regulatory T cell (Treg) differentiation are associated with ...
Marieke A van Leeuwen, M Fleur du Pré, Roy L van Wanrooij, Lilian F de Ruiter, H Rolien C Raatgeep, Dicky J Lindenbergh-Kortleve, Chris J Mulder, Lissy de Ridder, Johanna C Escher, Janneke N Samsom   +9 more
doaj   +1 more source

Severely ill and high-risk COVID-19 patients exhibit increased peripheral circulation of CD62L+ and perforin+ T cells

Frontiers in Immunology, 2023
IntroductionThe emergence of SARS-CoV-2, which causes COVID-19, has led to over 400 million reported cases worldwide. COVID-19 disease ranges from asymptomatic infection to severe disease and may be impacted by individual immune differences.MethodsWe ...
Kelsey E. Lesteberg, Kelsey E. Lesteberg, Paula Araya, Katherine A. Waugh, Katherine A. Waugh, Lakshmi Chauhan, Joaquin M. Espinosa, Joaquin M. Espinosa, J. David Beckham, J. David Beckham, J. David Beckham, J. David Beckham   +11 more
doaj   +1 more source

IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function. [PDF]

, 2019
Objective: We have previously shown that increased circulating interleukin-6 (IL-6) results in enhanced CD4+ T cell signaling via signal transduction and activator of transcription-3 (STAT3) in early rheumatoid arthritis (RA).
Aletaha, Alonzi, Anderson, Anderson, Arnett, Atsumi, Bettelli, Charlot-Rabiega, Chen, Choy, Dienz, Filer, Genovese, Heinrich, Hidalgo, Hunter, Isomaki, Jones, Karlson, Kokkonen, Kremer Joel, Kuuliala, Lawson, Liu, Manel, Ohshima, Pratt, Purvis, Purvis, Ridgley, Rincón, Sallusto, Smolen, Unutmaz   +33 more
core   +2 more sources

Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy. [PDF]

, 2019
Solid tumours are infiltrated by effector T cells with the potential to control or reject them, as well as by regulatory T (Treg) cells that restrict the function of effector T cells and thereby promote tumour growth1.
Cadilha, Bruno L, Carrizosa, Esteban, Di Pilato, Mauro, Kim, Edward Y, Ligorio, Matteo, Mani, Vinidhra, Marangoni, Francesco, Medoff, Benjamin D, Mempel, Thorsten R, Misale, Sandra, Nasrallah, Mazen N, Prüßmann, Jasper N, Seruggia, Davide, Usmani, Shariq M, Villani, Alexandra-Chloe, Warner, Ross D, Zappulli, Valentina   +16 more
core   +2 more sources

Cyclical expression of L-selectin (CD62L) by recirculating T cells [PDF]

International Immunology, 2009
L-Selectin (CD62L) mediates T-cell entry into lymph nodes. Whether the microenvironment modulates L-selectin expression of T cells during diapedesis and transit is unknown. Therefore, L-selectin expression was determined quantitatively on circulating T cells in blood, lymph nodes and thoracic duct by confocal laser scanning microscopy.
Antje, Klinger, Andreas, Gebert, Katja, Bieber, Kathrin, Kalies, Ann, Ager, Eric B, Bell, Jürgen, Westermann   +6 more
openaire   +2 more sources