Results 71 to 80 of about 49,530 (262)

Diversity of trends of viremia and T-cell markers in experimental acute feline immunodeficiency virus infection. [PDF]

PLoS ONE, 2013
OBJECTIVE: The early events of human immunodeficiency virus infection seem critical for progression toward disease and antiretroviral therapy initiation.
Sylvain Roche, Hanane El Garch, Sylvie Brunet, Hervé Poulet, Jean Iwaz, René Ecochard, Philippe Vanhems   +6 more
doaj   +1 more source

Influenza and memory T cells : how to awake the force [PDF]

, 2016
Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals.
Glezen, Hartshorn, Hufford, Jin, Jordan, Luo, Mosmann, Razvi, Topham, Topham, Topham, Von Andrian, Wijburg   +12 more
core   +3 more sources

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells [PDF]

, 2013
Memory T cells are composed of effector, central, and memory stem cells. Previous studies have implicated that both T-bet and Eomes are involved in the generation of effector and central memory CD8 T cells.
A Banerjee, AC Mullen, AM Intlekofer, AM Intlekofer, AM Intlekofer, B Lu, Binfeng Lu, CS Hinrichs, EL Pearce, F Pages, F Sallusto, Gang Li, GM Lord, Hong-Rui Wang, HZ Qui, I Atreya, JT Chang, K Kato, L Gattinoni, L Gattinoni, LJ Chen, M Wiesel, MA Paley, ME Pipkin, Mehrdad Matloubian, N Takemoto, NP Restifo, NS Joshi, Qianting Yang, SJ Szabo, WW Overwijk, X Zhou, Xinchun Chen, Xueguang Zhang, Y Zhang, Y Zhu, Yibei Zhu   +36 more
core   +7 more sources

TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. [PDF]

, 2019
CD4+ Foxp3+ T regulatory (Treg) cells are key players in preventing lethal autoimmunity. Tregs undertake differentiation processes and acquire diverse functional properties.
Cho, Sunglim, Dong, Yi, Feng, Gen-Sheng, Fu, Wenxian, Jepsen, Kristen, Liang, Yan, Lu, Li-Fan, Wan, Shuo, Wang, Ke, Xu, Wanqing, Xue, Hai-Hui, Yang, Bi-Huei, Yuan, Xiaomei   +12 more
core   +1 more source

Akt1 and -2 inhibition diminishes terminal differentiation and enhances central memory CD8(+) T-cell proliferation and survival [PDF]

, 2015
The authors thank Dr Esteban Celis and Dr Rhea-Beth Markowitz for reviewing the manuscript and for their valuable suggestions and also thank Dr Lei Huang for his suggestions.Peer reviewedPublisher ...
Abu Eid, Rasha, Friedman, Kevin M, Janik, John, Khleif, Samir N, King, William, Mkrtichyan, Mikayel, Walens, Andrea   +6 more
core   +1 more source

BCR-Mediated Decrease of CXCR4 and CD62L in CLL – Response [PDF]

Cancer Research, 2010
We previously reported that B-cell receptor (BCR) signaling promoted a concomitant decrease of CXCR4 and CD62L membrane expression only in progressive cases of chronic lymphocytic leukemia (CLL). Recently, Quiroga and colleagues raised some challenging issues and pointed out discrepancies between the two reports.
Amalia Vlad, Florence Ajchenbaum-Cymbalista, Nadine Varin-Blank, Dominique Ledoux   +3 more
openaire   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

CD4+T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C viruscoinfected patients [PDF]

, 2017
To characterize peripheral blood natural killer (NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients.
Cahn, Pedro, Laufer, Natalia Lorna, Martinez, Ana, Ojeda, Diego Sebastian, Polo, Maria Laura, Pérez, Héctor, Quarleri, Jorge Fabian, Turk, Gabriela Julia Ana, Zwirner, Norberto Walter   +8 more
core   +1 more source

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source