Results 201 to 210 of about 412,417 (244)

FLT3L-secreting cDC1 in situ vaccination enhances antitumor immunity and synergizes with PD-1 blockade in murine non-small cell lung cancer. [PDF]

J Immunother Cancer
Abascal J, Dumitras C, Tran LM, Crosson W, Kahangi B, Oh M, Rennels A, Lim RJ, Jiang H, Reyimjan D, Coleman NJ, Perez-Reyes E, Chin S, Krysan K, Dubinett SM, Liu B, Salehi-Rad R.   +16 more
europepmc   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Programmed cell death ligand 1 in correlation with <i>BRAF^V600E</i> mutation, molecular characteristics and biological behavior in ameloblastoma. [PDF]

Front Immunol
Pan A, Xie Z, Zhan J, Zhao Y, Du Y, Zhang K.   +5 more
europepmc   +1 more source

Enhancing Super‐Resolution Spatial Transcriptomics Data by Transfer Learning

Advanced Science, EarlyView.
SpotZoomer employs a transfer‐learning‐based strategy to enhance the resolution of Visium data by leveraging available high‐resolution priors. The resulting super‐resolved maps enable sharper delineation of cell boundaries and more precise inference of cell–cell communication patterns that would otherwise remain obscured at native resolution.
Xiaoyu Li, Lihua Zhang, Wenwen Min
wiley   +1 more source

CRISPR/Cas9-Mediated Gene Knockout Reveals a Nonredundant Role for p16^INK4A in Controlling TCR-Dependent and Independent CD8 T Cell Expansion. [PDF]

Eur J Immunol
Fiori S, Adragna C, Malvicini E, Basini T, Galgano D, Scarpa E, Jovic S, Schmacke NA, Hornung V, Sallusto F, Bruno L, Lanzavecchia A, Albanese M.   +12 more
europepmc   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Tumor cell ferroptosis in antitumor immunity and immunotherapy efficacy. [PDF]

J Immunother Cancer
Li S, Gajewski T.
europepmc   +1 more source

Berberine from Tibetan Medicine <i>Dracocephalum tanguticum</i> Maxim Suppresses Colorectal Tumor Growth and Inhibits CD8⁺ T Cells Ferroptosis via the NRF2-SLC7A11-GPX4 Axis. [PDF]

Cancer Manag Res
Wang Y, Zhang Y, Wang Q, Zheng L, Liu Y.
europepmc   +1 more source

Eliminating PD-L1 on Dendritic Cell Extracellular Vesicles for Immunotherapy Potentiates Immune-Mediated Tumour Rejection in Mice. [PDF]

J Extracell Vesicles
Teeuwen L, Steiner L, Reinhardt C, Offens A, Kuipers JE, Martínez-Martínez D, Mazouin J, Chambers BJ, Güçlüler Akpinar G, Gabrielsson S.   +9 more
europepmc   +1 more source

Neoadjuvant camrelizumab plus chemotherapy in resectable stage IIIA-IIIB non-small cell lung cancer: integrated multidimensional biomarker analysis from a phase II study. [PDF]

J Immunother Cancer
Cai G, Song P, Wang Z, Zhao J, Wang K, Li M, Wang X, Zhu J, Xu J, Huang B, Han X, Zhou H, Xie C, Fu S, Jia H, Teng F, Wang S, Sun H, Li W, Yu J, Meng X.   +20 more
europepmc   +1 more source