Results 1 to 10 of about 409,454 (264)
Immunohistochemical expression of programmed death-ligand 1 and CD8 in glioblastomas [PDF]
Journal of Pathology and Translational Medicine, 2021 Background Glioblastoma is the most aggressive primary malignant brain tumor in adults and is characterized by poor prognosis. Immune evasion occurs via programmed death-ligand 1 (PD-L1)/programmed death receptor 1 (PD-1) interaction.
Dina Mohamed El Samman +5 more
doaj +1 more source
Tumor Infiltrating Lymphocytes Predicting Long-Term Outcomes in HER2-Negative Breast Cancer Patients with Visceral Metastases [PDF]
Research in Oncology, 2022 Background: Tumor-infiltrating lymphocytes (TILs) were found to be associated with a better clinical outcome in specific subtypes of breast cancer. Aim: To study the association between TILs and the prognosis of Egyptian patients with HER2-negative ...
Elia Hakim +4 more
doaj +1 more source
Cytokines profile in patients with hydatidosis in Babylon Province, Iraq
Medical Journal of Babylon, 2023 Background: Hydatidosis is caused by infection with the larval stage of the Cestode Echinococcus granulosus. Objective: In vitro quantitative evaluation of interleukin 6 (IL-6), INF-gamma (INF-γ), and CD4 and CD8 molecules during hydatidosis infection ...
Ahmed Mohammed A Al-Mosawi +4 more
doaj +1 more source
CD8 Lineage Commitment in the Absence of CD8 [PDF]
Immunity, 1997 The absence of cytotoxic T lymphocyte activity and the failure of MHC class I-restricted T cell receptor (TCR) transgenic thymocytes to mature in CD8alpha-deficient mice suggest that CD8 may be essential for CD8 lineage commitment. We report that variants of the antigenic peptide that delete TCR transgenic thymocytes from CD8 wild-type but not CD8alpha-
Goldrath, Ananda W +2 more
openaire +2 more sources
CTL priming by CD8+ and CD8– dendritic cellsin vivo [PDF]
European Journal of Immunology, 1999 Two distinct developmental pathways are driving the formation of myeloid- and lymphoid-related dendritic cells (DC) which differ in anatomical localization and phenotype. In terms of function, it has been hypothesized that only the myeloid-related CD8(-) DC are able to initiate immune responses, whereas the lymphoid-related CD8(+) DC have been ...
Ruedl, C, Bachmann, M
openaire +3 more sources
Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct
OncoImmunology, 2022 Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8+ tumor-infiltrating lymphocytes (TILs).
Shamin Li +10 more
doaj +1 more source
Acta Veterinaria, 2021 Respiratory syncytial virus (RSV) is an RNA virus that belongs to the Pneumovirus genus of the Paramyxoviridae family. The aim of this study was to evaluate the expressions of inducible nitric oxide synthetase (iNOS), CD3 (pan T cells), and CD8 ...
Yaman Turan, Aydemir Ceyhun
doaj +1 more source
Cancer Biology & Medicine, 2023 Objective: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy. CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB) have been significantly correlated with the outcome of patients with PDAC, but the correlations have been ...
Tianxing Zhou +11 more
doaj +1 more source
Journal of Pathology Informatics, 2021 Background: Stromal CD8+ tumor-infiltrating lymphocytes (TILs) are an important prognostic and predictive indicator in non-small cell lung cancer (NSCLC).
Iny Jhun +5 more
doaj +1 more source
Robust antigen-specific CD8 T cell tolerance to a model prostate cancer neoantigen
OncoImmunology, 2020 Immunotherapy has shown limited success in prostate cancer; this may be partially explained by its immunosuppressive tumor microenvironment (TME). Although androgen-deprivation therapy (ADT), the most common treatment for prostate cancer, initially ...
Zoila A. Lopez-Bujanda +5 more
doaj +1 more source