Results 21 to 30 of about 409,454 (264)

Epithelial-to-mesenchymal transition and its association with PD-L1 and CD8 in thyroid cancer

Endocrine Connections, 2020
Programmed cell death-ligand 1 (PD-L1) has recently been shown to play a role in the regulation of epithelial-to-mesenchymal transition (EMT); however, the relationship between PD-L1 expression, EMT and the inflammatory tumour microenvironment has yet to
Marra Jai Aghajani, Tao Yang, Ulf Schmitz, Alexander James, Charles Eugenio McCafferty, Paul de Souza, Navin Niles, Tara L Roberts   +7 more
doaj   +1 more source

Schopenhauer and I. Kant in A. A. Fet’s philosophical and political worldview (conclusion) [PDF]

Кантовский сборник, 2013
The concluding part of the work focuses on the independence of A. A. Fet’s philosophical worldview strongly emphasised by the poet himself and his close friends. Although he quotes Schopenhauer and Kant, he criticised them and demonstrates an independent
Kalinnikov L.
doaj   +1 more source

KIR+CD8+ and NKG2A+CD8+ T cells are distinct innate-like populations in humans

Cell Reports, 2023
Summary: Subsets of the human CD8+ T cell population express inhibitory NK cell receptors, such as killer immunoglobulin-like receptors (KIRs) and NKG2A.
Seong Jin Choi, June-Young Koh, Min-Seok Rha, In-Ho Seo, Hoyoung Lee, Seongju Jeong, Su-Hyung Park, Eui-Cheol Shin   +7 more
doaj   +1 more source

Case Report: Early presentation of hereditary angioedema symptoms in a 2-year-old boy

Frontiers in Pediatrics
Hereditary angioedema (HAE) is a rare autosomal-dominant disease that is caused by a deficiency (type I) or dysfunction (type II) of the C1 inhibitor (C1-INH) due to a mutation in the SERPING1 gene, which codes for C1-INH.
Jurate Staikuniene-Kozonis, Jurate Staikuniene-Kozonis, Juste Staikunaite, Juste Staikunaite, Edita Gasiuniene, Justina Sematonyte   +5 more
doaj   +1 more source

Immune surveillance activation after neoadjuvant therapy for esophageal adenocarcinoma and complete response

OncoImmunology, 2020
After neoadjuvant chemoradiotherapy for esophageal adenocarcinoma, up to 29% of patients have a pathological complete response (pCR). What to do afterward is still under debate.
Andromachi Kotsafti, Melania Scarpa, Francesco Cavallin, Matteo Fassan, Roberta Salmaso, Andrea Porzionato, Luca Saadeh, Matteo Cagol, Rita Alfieri, Carlo Castoro, Massimo Rugge, Ignazio Castagliuolo, Marco Scarpa   +12 more
doaj   +1 more source

The Prognostic Value of Cytotoxic CD8-Positive Т-Lymphocytes of the Reactive Tumor Microenvironment in Diffuse Large B-Cell Lymphoma

Клиническая онкогематология
AIM. To assess the prognostic value of cytotoxic CD8-positive Т-lymphocytes of the reactive tumor microenvironment in diffuse large B-cell lymphoma (DLBCL). MATERIALS & METHODS. The study enrolled 124 patients with newly diagnosed DLBCL.
Elena Viktorovna Vaneeva, V. A. Rosin, D. A. Dyakonov, N. V. Glubokovskikh   +3 more
doaj   +1 more source

Perbedaan Ekspresi Foxp3+ dan Cd8+ Tumor Infiltrating Lymphocytes Karsinoma Payudara pada Berbagai Stadium T

Indonesian Journal of Cancer, 2018
Background: Breast carcinoma, the most common malignancy in women, are often accompanied by tumor infiltrating lymphocytes (TIL) which has controversial clinical relevance. TIL is thought to reflect the host’s immune response to malignant tumors.
Anisia Indiralia, Alphania Rahniayu, Sjahjenny Mustokoweni   +2 more
doaj   +1 more source

Formation and phenotypic characterization of CD49a, CD49b and CD103 expressing CD8 T cell populations in human metastatic melanoma

OncoImmunology, 2018
Integrins α1β1 (CD49a), α2β1 (CD49b) and αEβ7 (CD103) mediate retention of lymphocytes in peripheral tissues, and their expression is upregulated on tumor infiltrating lymphocytes (TIL) compared to circulating lymphocytes.
Marit M. Melssen, Walter Olson, Nolan A. Wages, Brian J. Capaldo, Ileana S. Mauldin, Adela Mahmutovic, Ciara Hutchison, Cornelis J.M. Melief, Timothy N. Bullock, Victor H. Engelhard, Craig L. Slingluff   +10 more
doaj   +1 more source

Distribution of melanocytes in the skin of psoriasis patients

Vestnik Dermatologii i Venerologii, 2019
Psoriasis is a chronic immune-mediated inflammatory disease with predominant damage to the skin and joints. Despite fundamental studies of its pathogenesis, the cause of the development of the T-cell response has not been determined. More recently, a new
A. S. Zhukov, V. R. Khairutdinov, I. E. Belousova, A. V. Samtsov   +3 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source