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Autoreactive CD8+ T-cells are highly dependent on CD8 for activation and as such targeting CD8 is an effective way of blocking autoreactive CD8+ T-cell activation

The Journal of Immunology, 2017
Abstract Autoimmune diseases such as type I diabetes (TID) and multiple sclerosis (MS) are chronic conditions that have a significant impact on quality of life. CD8+ T-cells play an important role in the pathogenesis of these diseases. However, drugs that target the entire CD8+ T-cell population are not desirable because this population ...
Linda Wooldridge, David Morgan, James Alexander Pearson, Stephanie Gras, Hugo van den Berg, Anya Lissina, Sian Llewellyn-Lacey, Mark Willis, Tamsin Dockree, James E McLaren, Julia Ekeruche-Makinde, Emma Gostick, Neil Robertson, Jamie Rossjohn, Scott R Burrows, David Price, Susan Wong, Mark Peakman, Ania Skowera, Matthew Clement   +19 more
openaire   +1 more source

CD8

2017
H. Renz, B. Gierten
openaire   +1 more source

CD8

2011
  +4 more sources

CD8

2019
H. Renz, B. Gierten
openaire   +1 more source

CD8+

2015
openaire   +2 more sources

CD8

1998
Georg F. Weber, Harvey Cantor
openaire   +1 more source

CD8

2009
openaire   +2 more sources

CD8

2008
openaire   +2 more sources

CD8

1997
A. Neil Barclay, Marion H. Brown, S.K. Alex Law, Andrew J. McKnight, Michael G. Tomlinson, P. Anton van der Merwe   +5 more
openaire   +1 more source

???????????????????? ???????????????????? ??-???????????????????? ?? ???????????? ?????????????????????????????????????? ?????????????? CD4/CD8 ?? ?????????? ???????????????????????????? ???????????????????? ?????? ????????????????- ?????????????????????? ?????????????????????? ????????????

2015
??????????????????????, ???? CD4+ ?? CD8+ ??-?????????????????? ?????????????????????????? ?? ???????????? ?????????????????? ?????????????? ?? ???????????????? ???????????????????????? ?????????????????? ?????????????????? ?????? ????????????????????????????????????. ?????????????????????? ?? ?????????????????????? ?????????????????????????? CD8+ ??-??
openaire   +1 more source