Results 221 to 230 of about 629,825 (307)

Immune control of functional memory CD8 T cells in normal-appearing vitiligo skin. [PDF]

Sci Adv
Migayron L, Merhi R, Avril C, Léonard S, Zouine A, Jouenne F, Gilardeau S, Drullion C, Thiolat D, Mertinaj E, Humeau M, Mauroux A, Guégan JP, Gauthereau X, Mourah S, Darde T, Bordes S, Closs-Gonthier B, Seneschal J, Boniface K.   +19 more
europepmc   +1 more source

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

Correction: Anti-correlation of KLRG1 and PD-1 expression in human tumor CD8 T cells. [PDF]

Oncotarget
Greenberg SA.
europepmc   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

CD8+ T cells in the tumor microenvironment modulate the response to endocrine therapy in breast cancer. [PDF]

J Clin Invest
Napolitano F, Wang Y, Sudhan DR, Gonzalez-Ericsson PI, Formisano L, Unni N, Shakeel S, Zhu JZ, Ahuja K, Guo L, Chica-Parrado MR, Matsunaga Y, Luna P, Lin CA, Uemoto Y, Lee KM, Ma H, Evans NJ, Servetto A, Mendiratta S, Barnes SD, Bianco R, Fang YV, Xu L, Lee J, Wang T, Balko JM, Mills GB, Labrie M, Hanker AB, Arteaga CL.   +30 more
europepmc   +1 more source

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation. [PDF]

Adv Sci (Weinh)
Chen X, Lin P, Lu Y, Zheng J, Lin Y, Zhou Z, Cui L, Zhao X.   +7 more
europepmc   +1 more source

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

Advanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren, Zhihong Deng, Sheng Lu, Jing Zhang, Wenbin Liu, Jia Tan   +5 more
wiley   +1 more source

Allogeneic haematopoietic cell transplantation promotes atherosclerosis in mice via CD8+ T cells. [PDF]

Cardiovasc Res
Jorgacevic I, Shaikh H, Ali H, Bundalo M, Schäfer S, Kern MAG, Büttner-Herold M, Reu-Hofer S, Cochain C, Bartolomaeus H, Saliba AE, Rösch M, Rizzo G, Arellano Viera E, Gamboa Vargas J, Berberich-Siebelt F, Herr W, Boon L, Rosenwald A, Butt E, Hermanns HM, Beilhack A, Zernecke A.   +22 more
europepmc   +1 more source