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The Era of Cytotoxic CD4 T Cells
Frontiers in Immunology, 2022 In 1986, Mosmann and Coffman identified 2 functionally distinct subsets of activated CD4 T cells, Th1 and Th2 cells, being key in distinct T cell mediated responses.
Mara Cenerenti +7 more
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Cytotoxic T cells and mycobacteria [PDF]
FEMS Microbiology Letters, 2001 How the immune system kills Mycobacterium tuberculosis is still a puzzle. the classical picture of killing due to phagocytosis by activated macrophages may be only partly correct.
Bonato, Vania LD +7 more
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Frontiers in Immunology, 2022 Cytotoxic CD4+ T cells (CD4-CTLs) show the presence of cytolytic granules, which include the enzymes granzyme and perforin. The cells have a pathogenic and protective role in various diseases, including cancer, viral infection, and autoimmune disease. In
Shun Tanemoto +22 more
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The Expanding Arsenal of Cytotoxic T Cells
Frontiers in Immunology, 2022 Cytotoxic T cells (CTLs) are the main cellular mediators of the adaptive immune defenses against intracellular pathogens and malignant cells. Upon recognition of specific antigen on their cellular target, CTLs assemble an immunological synapse where they
Chiara Cassioli, Cosima T. Baldari
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T cells in ITP: Focus on T follicular helper cells and cytotoxic T cells. [PDF]
Br J HaematolSummary Immune thrombocytopenia (ITP) is an autoimmune disease where premature destruction of platelets as well as inhibition of platelet production leads to thrombocytopenia and associated bleeding. It has long been considered a disease primarily caused by B cells, but the role of T lymphocytes in its pathogenesis is now better ...
Audia S, Cooper N.
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Journal of Investigative Dermatology, 2006 The immune system is a complex arrangement of cells and molecules that preserve the integrity of the organism by elimination of all elements judged dangerous. Within the immune system, a humoral and a cellular as well as an innate and an adaptive arm can be differentiated.
Andersen, Mads Hald +3 more
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Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells
Journal for ImmunoTherapy of Cancer, 2022 Background High expression of the metabolic enzyme arginase-2 (ARG2) by cancer cells, regulatory immune cells, or cells of the tumor stroma can reduce the availability of arginine (L-Arg) in the tumor microenvironment (TME).
Marco Donia +14 more
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Imbalance between subsets of CD8+ peripheral blood T cells in patients with chronic obstructive pulmonary disease [PDF]
PeerJ, 2016 Background. CD8+ T lymphocytes are known to play a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, systematic analyses of CD8+ T cell (Cytotoxic T cells, Tc) subsets in COPD patients have yet to be well ...
Long Chen +9 more
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Impaired Cytotoxic CD8+ T Cell Response in Elderly COVID-19 Patients
mBio, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell response that most likely contributes to virus control in COVID-19 patients but may also induce immunopathology. Until now, the cytotoxic T cell response has not been
Jaana Westmeier +19 more
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