Results 21 to 30 of about 2,965,907 (391)

Distinct Roles of Vav Family Members in Adaptive and Innate Immune Models of Arthritis

Biomedicines, 2021
Genetic evidence suggests that three members of the VAV family (VAV1, VAV2 and VAV3) of signal transduction proteins could play important roles in rheumatoid arthritis.
Javier Conde, Isabel Fernández-Pisonero, Myriam Cuadrado, Antonio Abad, Javier Robles-Valero, Xosé R. Bustelo   +5 more
doaj   +1 more source

Inhibition of MICA and MICB Shedding Elicits NK cell–mediated Immunity against Tumors Resistant to Cytotoxic T cells

Cancer immunology research, 2020
Tumor cells evade NK-cell–mediated immunity by proteolytic shedding of the activating MICA/B ligands. Use of a MICA/B antibody inhibits MICA/B proteolytic shedding, leading to NK-cell responses against tumor cells resistant to cytotoxic T cells ...
Lucas Ferrari de Andrade, Sushil Kumar, Adrienne M. Luoma, Yoshinaga Ito, P. H. Alves da Silva, D. Pan, Jason W Pyrdol, Charles H. Yoon, K. Wucherpfennig   +8 more
semanticscholar   +1 more source

Clinical significance of plasmacytoid dendritic cells and myeloid-derived suppressor cells in melanoma [PDF]

, 2015
Background: Immune markers in the peripheral blood of melanoma patients could provide prognostic information. However, there is currently no consensus on which circulating cell types have more clinical impact.
Bachert, Claus, Brochez, Lieve, CHEVOLET, INES, Krysko, Olga, Neyns, Bart, Schreuer, Max, Speeckaert, Reinhart, van Geel, Nanja, Van Gele, Mireille   +8 more
core   +2 more sources

Maintenance of Functional CD57+ Cytolytic CD4+ T Cells in HIV+ Elite Controllers

Frontiers in Immunology, 2019
Cytolytic CD4+ T cells play a prominent role in chronic viral infection. CD4+ CTLs clones specific for HIV-1 Nef and Gag are capable of killing HIV-1 infected CD4+ T cells and macrophages.
Chansavath Phetsouphanh, Daniel Aldridge, Emanuele Marchi, C. Mee Ling Munier, Jodi Meyerowitz, Lyle Murray, Cloete Van Vuuren, Dominique Goedhals, Sarah Fidler, Anthony Kelleher, Paul Klenerman, John Frater   +11 more
doaj   +1 more source

Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the α3 domain of MHC I molecules [PDF]

, 1991
THE α1 and α2 domains of major histocompatibility complex (MHC) class I molecules function in the binding and presentation of foreign peptides to the T-cell antigen receptor and control both negative and positive selection of the T-cell repertoire ...
AM Norment, Carla J. Aldrich, CJ Aldrich, CJ Aldrich, HR MacDonald, HS Teh, HS Teh, HS Teh, IA Stroynowski, IS Trowbridge, Iwona Stroynowski, J Sprent, James Forman, JC Zuniga-Pflucker, JM Connolly, Lee Hood, M Reddehase, MA Alexander, PJ Bjorkman, R Salter, RC Budd, Robert E. Hammer, RR Zamoyska, S Marusic-Galesic, S Qin, Sharon Jones-Youngblood, UH Koszinowski, Ulrich Koszinowski, W-P Fung-Leung, WR Lie, WR Lie   +30 more
core   +1 more source

Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo

Journal of Experimental Medicine, 2000
Bone marrow–derived antigen-presenting cells (APCs) take up cell-associated antigens and present them in the context of major histocompatibility complex (MHC) class I molecules to CD8+ T cells in a process referred to as cross-priming.
J. D. den Haan, S. Lehar, M. Bevan
semanticscholar   +1 more source

Diminished Frequencies of Cytotoxic Marker Expressing T- and NK Cells at the Site of Mycobacterium tuberculosis Infection

Frontiers in Immunology, 2020
Tuberculous lymphadenitis (TBL) individuals exhibit reduced frequencies of CD8+ T cells expressing cytotoxic markers in peripheral blood. However, the frequencies of cytotoxic marker expressing CD4+, CD8+ T cells, and NK cells at the site of infection is
Gokul Raj Kathamuthu, Gokul Raj Kathamuthu, Kadar Moideen, Rathinam Sridhar, Dhanaraj Baskaran, Subash Babu, Subash Babu   +6 more
doaj   +1 more source

CCR6 and CXCR6 Identify the Th17 Cells With Cytotoxicity in Experimental Autoimmune Encephalomyelitis

Frontiers in Immunology, 2022
Due to the plasticity of IL-17-producing CD4 T cells (Th17 cells), a long-standing challenge in studying Th17-driven autoimmune is the lack of specific surface marker to identify the pathogenic Th17 cells in vivo.
Lifei Hou, Lifei Hou, Koichi Yuki, Koichi Yuki   +3 more
doaj   +1 more source

Cytotoxic polyfunctionality maturation of cytomegalovirus-pp65-specific CD4 + and CD8 + T-cell responses in older adults positively correlates with response size [PDF]

, 2016
Cytomegalovirus (CMV) infection is one of the most common persistent viral infections in humans worldwide and is epidemiologically associated with many adverse health consequences during aging.
A Harari, A Lelic, AM Simanek, AR Hersperger, AW Sylwester, C Courivaud, C Riou, E Derhovanessian, E Gimenez, E Sinclair, EJ Wherry, ET Roberts, F Bihl, F Kern, F Sallusto, G Makedonas, G Makedonas, G Pawelec, G Pawelec, GC Wang, GC Wang, IG Rodrigue-Gervais, J Cheng, J van Zanten, JM Fletcher, L Cicin-Sain, L Cicin-Sain, L Krol, ML Pita-Lopez, MR Betts, MR Wills, N Khan, P Trzonkowski, PA Darrah, Q Ouyang, R Lachmann, R Solana, R Vescovini, RA Seder, RA van Lier, S Cantisan, SA Migueles, SH Park, SR Hadrup, T Crough, V Appay, YL Chiu, YN Ji   +47 more
core   +1 more source

Differential Cytotoxic Function of Resident and Non-resident CD8+ T Cells in the Human Female Reproductive Tract Before and After Menopause

Frontiers in Immunology, 2020
The functional characterization and regulation of tissue resident and non-resident CD8+ T cells in the human female reproductive tract (FRT) as women age remains a gap in our knowledge.
Marta Rodriguez-Garcia, Marta Rodriguez-Garcia, Zheng Shen, Jared M. Fortier, Charles R. Wira   +4 more
doaj   +1 more source