Results 21 to 30 of about 14,427,848 (200)

Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection [PDF]

, 2001
Cytotoxic T lymphocytes (CTLs) play a vital part in controlling viral replication during human viral infections. Most studies in human infections have focused on CTL specificities in chronic infection and few data exist regarding the specificity of the ...
Sekaly, R.P., Eldridge, RL, Kalams, SA, Altfeld, M.A., He, S, Phillips, M.N., He, S., Phillips, MN, Tang, Y, Eldridge, R.L., Walker, B.D., Nguyen, T, Addo, MM, Muckerjee, J.S., Rosenberg, ES, Walker, BD, Nguyen, T.T., Bunce, M, Addo, M.M., Kalams, S.A., Mukherjee, JS, Rosenberg, E.S., Brander, C, Goulder, P.J.R., Brander, C., Goulder, PJ, Altfeld, MA, Sekaly, RP, Tang, Y., Bunce, M.   +29 more
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Diminished Frequencies of Cytotoxic Marker Expressing T- and NK Cells at the Site of Mycobacterium tuberculosis Infection

Frontiers in Immunology, 2020
Tuberculous lymphadenitis (TBL) individuals exhibit reduced frequencies of CD8+ T cells expressing cytotoxic markers in peripheral blood. However, the frequencies of cytotoxic marker expressing CD4+, CD8+ T cells, and NK cells at the site of infection is
Gokul Raj Kathamuthu, Gokul Raj Kathamuthu, Kadar Moideen, Rathinam Sridhar, Dhanaraj Baskaran, Subash Babu, Subash Babu   +6 more
doaj   +1 more source

Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with Hepatitis B virus infection [PDF]

, 2005
CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of patients with chronic and resolved ...
Gotto, J, Ornella Franzese, Antonio Bertoletti, Maini, Mk, Franzese, O., Williams, R., Adam J. Gehring, Gehring, A.J., Roger Williams, Gehring, Aj, Gotto, J., Bertoletti, A., Kennedy, P.T.F., Williams, R, Maini, M.K., Patrick T. F. Kennedy, Kennedy, Ptf, Jim Gotto, Mala K. Maini, FRANZESE, ORNELLA   +19 more
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Swift development of protective effector functions in naive CD8(+) T cells against malaria liver stages. [PDF]

, 2001
We generated T cell receptor transgenic mice specific for the liver stages of the rodent malaria parasite Plasmodium yoelii and studied the early events in the development of in vivo effector functions in antigen-specific CD8(+) T cells.
Lafaille, JJ, Gen-ichiro Sano, Alexandre Morrot, Abe, R, Juan J. Lafaille, Fidel Zavala, Sano, G, Ryo Abe, Julius C.R. Hafalla, Hafalla, JC, Morrot, A, Zavala, F   +11 more
core   +1 more source

Regulatory T-Cells Suppress Cytotoxic T Lymphocyte Responses against Microglia

Cells, 2022
Regulatory T-cells (Tregs) play pivotal roles during infection, cancer, and autoimmunity. In our previous study, we demonstrated a role for the PD-1:PD-L1 pathway in controlling cytolytic responses of CD8+ T lymphocytes against microglial cells ...
Priyanka Chauhan, Shuxian Hu, Wen S. Sheng, James R. Lokensgard   +3 more
doaj   +1 more source

Adjuvant activity of ethanol extract of Hippophae rhamnoides leaves with inactivated rabies virus antigen

Pharmaceutical Biology, 2018
Context: Hippophae rhamnoides L. (Elaeagnaceae), commonly known as seabuckthorn (SBT), is known for its medicinal and nutritional properties. Objective: Evaluation of in vivo adjuvant activity of SBT leaf extract (SBTE) with inactivated rabies virus ...
D. Singh, B. Jayashankar, K. P. Mishra, H. Tanwar, S. N. Madhusudana, A. Y. Belludi, R. Tulsawani, S. B. Singh, L. Ganju   +8 more
doaj   +1 more source

Characterization of human cytomegalovirus peptide-specific CD8⁺ T-cell repertoire diversity following in vitro restimulation by antigen-pulsed dendritic cells [PDF]

, 2002
Under conditions of impaired T-cell immunity, human cytomegalovirus (HCMV) can reactivate from lifelong latency, resulting in potentially fatal disease.
Moss, Paul; id_orcid, Karl Peggs, Moss, P, Pizzey, A, Stephanie Verfuerth, Ainsworth, Jennifer, Peggs, K, Verfuerth, S, Mackinnon, S, Ainsworth, J, Paul Moss, Stephen Mackinnon, Jenni Ainsworth, Arnold Pizzey   +13 more
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Comparative Analysis of Extracellular Vesicles from Cytotoxic CD8⁺ αβ T Cells and γδ T Cells

Cells
Background: Although belonging to different branches of the immune system, cytotoxic CD8+ αβ T cells and γδ T cells utilize common cytolytic effectors including FasL, granzymes, perforin and granulysin.
Lisa Griesel, Patrick Kaleja, Andreas Tholey, Marcus Lettau, Ottmar Janssen   +4 more
doaj   +1 more source

Emerging Cellular Therapies: T Cells and Beyond

Cells, 2019
Cellular therapies, including those based on T cells, are becoming approved options for clinicians treating a range of diseases. Cytotoxic T lymphocytes (CTLs) can be modified ex vivo to express receptors such as chimeric antigen receptors (CARs) or T ...
Stephen Todryk, Agnieszka Jozwik, Julian de Havilland, Joanna Hester   +3 more
doaj   +1 more source

Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in Human Immunodeficiency Virus Type 1 infection [PDF]

, 2004
Numerous studies now support that human immunodeficiency virus type 1 (HIV-1) evolution is influenced by immune selection pressure, with population studies showing an association between specific HLA alleles and mutations within defined cytotoxic T ...
O'Sullivan, K.M., Mothe, B.R., Kalife, ET, Johnston, MN, Altfeld, M., Kalife, E.T., Strick, D.A., Lee, PK, Yu, X.G., Mallal, SA, Walker, B.D., Rosenberg, ES, Mothe, BR, Allen, T.M., Cohen, D.E., Altfeld, M, Sette, A., Walker, BD, Sette, A, John, M., Johnston, M.N., Rosenberg, E.S., O'Sullivan, KM, Le Gall, S, Allen, TM, Brander, C, John, M, Goulder, P.J.R., Brander, C., Goulder, PJ, Lichterfeld, M, Freedberg, K.A., Cohen, DE, Freedberg, KA, Mallal, S.A., Lee, P.K., Yu, XG, Le Gall, S., Lichterfeld, M., Strick, DA   +39 more
core   +1 more source