Results 41 to 50 of about 14,427,848 (200)

Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89 [PDF]

, 1988
The murine cytomegalovirus protein pp89, which is encoded by gene ieI, is a nonstructural regulatory protein expressed in the immediate-early phase of the viral replication cycle and located mainly in the nucleus of infected cells.
Reddehase, Matthias J., Del Val, Margarita, Koszinowski, Ulrich H., Schickedanz, Jörg, Volkmer, Hansjürgen, Messerle, Martin, Jonjic, Stipan, Rothbard, Jonathan B.   +7 more
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Immune-Mediated Cytotoxicity in Inflammatory Bowel Disease

Canadian Journal of Gastroenterology, 1990
Thirty years of research on the role of immune-mediated cytotoxic activity in the tissue injury of inflammatory bowel disease (IBD) has yielded only inconclusive data on the relevance of cytotoxic mechanisms. Two hypotheses have been advanced.
Stephan R Targan, Richard L Deem, Fergus Shanahan   +2 more
doaj   +1 more source

Signals Controlling Lytic Granule Polarization at the Cytotoxic Immune Synapse

Frontiers in Immunology, 2018
Cytotoxic immunity relies on specialized effector T cells, the cytotoxic T cells, which are endowed with specialized cytolytic machinery that permits them to induce death of their targets. Upon recognition of a target cell, cytotoxic T cells form a lytic
Anna Kabanova, Vanessa Zurli, Cosima Tatiana Baldari   +2 more
doaj   +1 more source

The Interplay between Bluetongue Virus Infections and Adaptive Immunity

Viruses, 2021
Viral infections have long provided a platform to understand the workings of immunity. For instance, great strides towards defining basic immunology concepts, such as MHC restriction of antigen presentation or T-cell memory development and maintenance ...
Daniel Rodríguez-Martín, Andrés Louloudes-Lázaro, Miguel Avia, Verónica Martín, José M. Rojas, Noemí Sevilla   +5 more
doaj   +1 more source

Porcine γδ T cells express cytotoxic cell-associated markers and display killing activity but are not selectively cytotoxic against PRRSV- or swIAV-infected macrophages

Frontiers in Immunology
BackgroundGamma-delta (γδ) T cells are a major immune cell subset in pigs. Approximately 50% of circulating T cells are γδ T cells in young pigs and up to 30% in adult sows.
Leonie Bettin, Leonie Bettin, Joseph Darbellay, Jill van Kessel, Neeraj Dhar, Neeraj Dhar, Neeraj Dhar, Volker Gerdts, Volker Gerdts   +8 more
doaj   +1 more source

Rejection of Experimental Hodgkins Lymphoma by T-cells Engineered with a CD19 Chimeric Antigen Receptor [PDF]

, 2012
T cells engineered to express chimeric receptors combining an external antibody binding domain with the CD3ζ T cell receptor (TCR) internal domain for triggering cell activation are being used for immunotherapeutic targeting of tumour cells in a non-HLA ...
Cheadle, Eleanor, Johannessen, Ingolfur, Talbot, Simon, Cheadle, Eleanor J, Crawford, Dorothy, Gilham, David, Gilham, David E, Johannessen, Ingo, Swanson, Anna   +8 more
core   +1 more source

DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire [PDF]

, 2008
The majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets.
Buchan, Sarah L., Timothy J. Kendall, Philip D. Greenberg, Michelle L. Dossett, Stuart N. Dunn, Öhlén, Claes, Rice, Jason, Dossett, Michelle L., Dossett, Michelle L, Stevenson, Freda K., Kendall, Timothy J., Sarah L. Buchan, Freda K. Stevenson, Dunn, Stuart N, Greenberg, Philip D, Dunn, Stuart N., Greenberg, Philip D., Kendall, Timothy J; id_orcid, Stevenson, Freda K, Jason Rice, Buchan, Sarah L, Claes Öhlén   +21 more
core   +1 more source

Cytotoxic CD4+ T cells: origin, biological functions, diseases and therapeutic targets

Signal Transduction and Targeted Therapy
Cytotoxic CD4+ T lymphocytes are a unique subset of CD4+ T cells characterized by their cytokine secretion and cytolytic activity. Unlike traditional CD4+ helper T cells, cytotoxic CD4+ T lymphocytes exhibit similar cytotoxicity to that of CD8+ T cells ...
Longyong Lai, Shuan Ran, Yuan Li, Jikai Cui, Xi Zhang, Jizhang Yu, Yanqiang Zou, Cheng Zhou, Jiahong Xia, Jie Wu   +9 more
doaj   +1 more source

Cytotoxic T-Cell Immunity to Influenza

New England Journal of Medicine, 1983
In a study designed to determine whether cytotoxic T lymphocytes contribute to immunity against influenza virus infection, we inoculated 63 volunteers intranasally with live unattenuated influenza A/Munich/1/79 virus. Over the next seven days clinical observations were made, and the amount of virus shed was measured.
Mcmichael, A, Gotch, F, Noble, G, Beare, P   +3 more
openaire   +2 more sources

Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein [PDF]

, 2001
The BCR-ABL oncogene is central in the pathogenesis of chronic myeloid leukemia (CML). Here, tandem nanospray mass spectrometry was used to demonstrate cell surface HLA- associated expression of the BCR-ABL peptide KQSSKALQR on class I-negative CIVIL ...
Lill, JR, Christmas, SE, Wang, LH, Macintyre, AR, Bourdon, A, Hill, SC, Rojas, J, Dodi, IA, Bonner, PLR, Aubert, G, Creaser, CS, Clark, RE, Rees, RC, Travers, PJ, Madrigal, JA   +14 more
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