Results 41 to 50 of about 2,965,907 (391)

Shared determinants between virus-infected and trinitrophenyl-conjugated H-2-identical target cells detected in cell-mediated lympholysis [PDF]

, 1976
Infection of H-2-identical mice with either lymphocytic choriomeningitis (LCM) virus, vaccinia virus, or paramyxo (Sendai) virus resulted in the generation of specifically sensitized cytotoxic T lymphocytes (CTL).
Bevan, Canty, Doherty, Doherty, Ertl, Forman, Gordon, Herberman, Koszinowski, Pfizenmaier, Pfizenmaier, Pfizenmaier, Shearer, Shreffler, Wagner, Wekerle, Zinkernagel   +16 more
core   +1 more source

Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells

Science immunology, 2019
Cytotoxic T cells use actin-rich protrusions at the immunological synapse to enhance perforin-mediated target cell killing. Zooming in on the kiss of death Cytotoxic T lymphocytes (CTLs) engage and kill antigen-specific target cells by injecting toxic ...
Fella Tamzalit, Mitchell S. Wang, Weiyang Jin, M. Tello-Lafoz, Vitaly P. Boyko, John M. Heddleston, C. Black, L. Kam, M. Huse   +8 more
semanticscholar   +1 more source

Cytotoxic CD4+ T cells in cancer: Expanding the immune effector toolbox

Immunity, 2021
SUMMARY Cytotoxic T cells are important effectors of anti-tumor immunity. While tumor killing is ascribed to CD8+ T cell function, pre-clinical and clinical studies have identified intra-tumoral CD4+ T cells that possess cytotoxic programs and can ...
D. Oh, L. Fong
semanticscholar   +1 more source

Comparative Analysis of Extracellular Vesicles from Cytotoxic CD8⁺ αβ T Cells and γδ T Cells

Cells
Background: Although belonging to different branches of the immune system, cytotoxic CD8+ αβ T cells and γδ T cells utilize common cytolytic effectors including FasL, granzymes, perforin and granulysin.
Lisa Griesel, Patrick Kaleja, Andreas Tholey, Marcus Lettau, Ottmar Janssen   +4 more
doaj   +1 more source

CD8+ T-cell responses in vaccination: Reconsidering targets and function in the context of chronic antigen stimulation [PDF]

, 2018
Cytotoxic CD8 T cells play important roles in eliminating infected and transformed cells. Owing to their potential for therapeutic applications, significant efforts are dedicated toward developing CD8 T cell-based vaccines.
Cosma, Gabriela L., Eisenlohr, Laurence
core   +2 more sources

NFκB in Pancreatic Stellate Cells Reduces Infiltration of Tumors by Cytotoxic T Cells and Killing of Cancer Cells, via Upregulation of CXCL12

Gastroenterology, 2018
Background & Aims Immunotherapies are ineffective against pancreatic cancer. We investigated whether the activity of nuclear factor (NF)κB in pancreatic stromal cells contributes to an environment that suppresses anti-tumor immune response.
B. Garg, Bhuwan Giri, S. Modi, Vrishketan Sethi, I. Castro, O. Umland, Yuguang Ban, Shweta P Lavania, R. Dawra, Sulagna Banerjee, S. Vickers, N. Merchant, S. Chen, E. Gilboa, S. Ramakrishnan, A. Saluja, V. Dudeja   +16 more
semanticscholar   +1 more source

Different In Situ Immune Patterns between Primary Tumor and Lymph Node in Non-Small-Cell Lung Cancer: Potential Impact on Neoadjuvant Immunotherapy

Journal of Immunology Research, 2022
Background. Neoadjuvant immunotherapy is promising for locally advanced non-small-cell lung cancer (NSCLC). The in situ immune patterns, as a predictor of PD-1/PD-L1 blockade outcomes, of the primary tumor (PT) and metastatic lymph nodes (mLNs) are ...
Zheng-Hao Ye, Hao Long, Ze-Rui Zhao
doaj   +1 more source

Lysis mediated by T cells and restricted by H-2 antigen of target cells infected with vaccinia virus [PDF]

, 1975
VARIOUS virus infections lead to the formation of cytotoxic lymphocytes (CL), which are capable of killing virus-infected target cells1−4. Specific lysis of target cells infected with 51Cr-labelled vaccinia virus could be observed when investigating the ...
GJ Hämmerling, GM Shearer, H. ERTL, HR McFarland, I Gardner, LF Speel, M Nabholz, M Schlesinger, O Marker, RM Zinkernagel, RM Zinkernagel, RM Zinkernagel, RV Blanden, U. KOSZINOWSKI   +13 more
core   +1 more source

Cytotoxic T cells use mechanical force to potentiate target cell killing

Cell, 2016
SUMMARY The immunological synapse formed between a cytotoxic T lymphocyte (CTL) and an infected or transformed target cell is a physically active structure capable of exerting mechanical force.
Roshni Basu, Benjamin Whitlock, J. Husson, A. Floc’h, Weiyang Jin, Alon Oyler-Yaniv, Farokh Dotiwala, Grégory Giannone, C. Hivroz, N. Biais, J. Lieberman, L. Kam, M. Huse   +12 more
semanticscholar   +1 more source

Cytotoxic CD8+ T cells in cancer and cancer immunotherapy

British Journal of Cancer, 2020
The functions of, and interactions between, the innate and adaptive immune systems are vital for anticancer immunity. Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of
H. Raskov, A. Orhan, J. Christensen, I. Gögenur   +3 more
semanticscholar   +1 more source