Results 51 to 60 of about 14,427,848 (200)

Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis [PDF]

, 2009
Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis Background: The role of cytotoxicity of NKT-cells in the skin is not defined. There are two prototypic skin diseases in which epidermal Keratinocytes (KC) over-express CD1d, a
Balato, Anna
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Cytotoxic T cells swarm by homotypic chemokine signalling

eLife, 2020
Cytotoxic T lymphocytes (CTLs) are thought to arrive at target sites either via random search or following signals by other leukocytes. Here, we reveal independent emergent behaviour in CTL populations attacking tumour masses.
Jorge Luis Galeano Niño, Sophie V Pageon, Szun S Tay, Feyza Colakoglu, Daryan Kempe, Jack Hywood, Jessica K Mazalo, James Cremasco, Matt A Govendir, Laura F Dagley, Kenneth Hsu, Simone Rizzetto, Jerzy Zieba, Gregory Rice, Victoria Prior, Geraldine M O'Neill, Richard J Williams, David R Nisbet, Belinda Kramer, Andrew I Webb, Fabio Luciani, Mark N Read, Maté Biro   +22 more
doaj   +1 more source

Activation of CD4 and CD8 T cell receptors and regulatory T cells in response to human proteins [PDF]

PeerJ, 2018
This study assessed in detail the influence of four different human proteins on the activation of CD4+ and CD8+ T lymphocytes and on the formation of regulatory T cells. Human whole-blood samples were incubated with four different human proteins.
Borros M. Arneth
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Novel, cross-restricted, conserved, and immunodominant Cytotoxic T Lymphocyte epitopes in slow progressors in HIV Type 1 infection [PDF]

, 1996
HIV-specific cytotoxic T lymphocytes (CTLs) play an important role in the immune response to HIV infection. Long-term nonprogressors (LTNPs) or slow progressors (SPs) in HIV infection may make qualitatively different CTL responses compared to those ...
KARL McINTYRE, RODNEY E. PHILLIPS, Phillips, Rodney, Krausa, P, Phillips, R.E., Giangrande, P, SIOBHAN CROWLEY, Edwards, A., McIntyre, K., MIKE BUNCE, Morgan, B., Edwards, A, McMichael, A.J., Crowley, S, BARBARA MORGAN, ANNE EDWARDS, Morgan, B, Bunce, M, McMichael, Andrew, PETER KRAUSA, Crowley, S., Krausa, P., Goulder, P.J.R., Goulder, PJ, McIntyre, K, PAUL GIANGRANDE, ANDREW J. McMICHAEL, Giangrande, P., PHILIP J.R. GOULDER, McMichael, AJ, Bunce, M., Phillips, RE   +31 more
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A mathematical model of cytotoxic and helper T cell interactions in a tumour microenvironment

Letters in Biomathematics, 2018
We develop a mathematical model to examine the role of helper and cytotoxic T cells in an anti-tumour immune response. The model comprises three ordinary differential equations describing the dynamics of the tumour cells, the helper and the cytotoxic T ...
Heidi Dritschel, Sarah L. Waters, Andreas Roller, Helen M. Byrne   +3 more
doaj   +1 more source

Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNF alpha therapy [PDF]

, 2004
Regulatory T cells have been clearly implicated in the control of disease in murine models of autoimmunity. The paucity of data regarding the role of these lymphocytes in human autoimmune disease has prompted us to examine their function in patients with
Jamie G. Evans, Gary Warnes, Mauri, C, Isenberg, DA, Warnes, G, Samantha Moore, Michael R. Ehrenstein, Evans, JG, Moore, S, Singh, A, David A. Isenberg, Claudia Mauri, Ehrenstein, MR, Animesh Singh   +13 more
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Conditional immortalization of human B cells by CD40 ligation [PDF]

, 2008
It is generally assumed that human differentiated cells have a limited life-span and proliferation capacity in vivo, and that genetic modifications are a prerequisite for their immortalization in vitro.
Mayr, C., Caroline Zentz, Reinhard Zeidler, Hammerschmidt, W., Wolfgang Hammerschmidt, Wiesner, Martina, Wimmer, Rainer, Wiesner, M., Christine Mayr, Hammerschmidt, Wolfgang, Zentz Caroline, Zentz, C., Moosmann, A., Zeidler, Reinhard, Wiesner Martina, Moosmann Andreas, Andreas Moosmann, Mayr Christine, Wimmer, R., Wimmer Rainer, Zentz, Caroline, Hammerschmidt Wolfgang, Mayr, Christine, Martina Wiesner, Moosmann, Andreas, Rainer Wimmer, Zeidler Reinhard, Zeidler, R.   +27 more
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Alloreactive cytotoxic T lymphocytes generated in the presence of viral- derived peptides show exquisite peptide and MHC specificity [PDF]

, 1993
The nature of alloreactivity to MHC molecules has been enigmatic, primarily because of the observation that allogeneic responses are considerably stronger than syngeneic responses. To better determine the specificity potential of allogeneic responses, we
Connolly, J. M., Koszinowski, Ulrich H., Alexander-Miller, M. A., Burke, K., Hansen, T. H.   +4 more
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Expansion of CD4+ T cells with a cytotoxic phenotype in patients with B-chronic lymphocytic leukaemia (B-CLL)

, 2001
Abnormal CD4/CD8 ratios and T-cell function have previously been shown in patients with B-chronic lymphocytic leukaemia (B-CLL). We have demonstrated that CD4+ T cells containing both serine esterase and perforin (PF) are increased in the blood of these ...
Roschupkina, T., Patterson, K., Jewell, A.P., Yong, K., Yong, K.L., Lydyard, P.M., Porakishvili, N., Kalber, T.   +7 more
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Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity [PDF]

, 2012
Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8+
James P. Hindley, Ann Ager, van den Berg, Hugo A., McLaren, James Edward, Ladell, Kristin Ingrid, Marsden, Morgan, Hindley, James P., Godkin, Andrew, McLaren, James E., Price, D. A., James E. McLaren, Mathew Clement, Bridgeman, Hayley, Ian R. Humphreys, David A. Price, Hindley, James Philip, Gallimore, Awen Myfanwy, Humphreys, Ian R., Linda Wooldridge, Hugo A. van den Berg, Godkin, Andrew James, Clement, Mathew, Ager, Ann, Berg, Hugo van den, Hayley M. Bridgeman, Kristin Ladell, Andrew Godkin, Awen M. Gallimore, Morgan Marsden, Ladell, Kristin, Smart, Kathryn, Price, David, Kathryn Smart, Bridgeman, Hayley M., Wooldridge, Linda, Gallimore, Awen M.   +35 more
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