Results 61 to 70 of about 14,427,848 (200)

Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells : implications for adoptive immunotherapy after allogeneic stem cell transplantation [PDF]

, 2010
Background: Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood and has a poor prognosis. Here we assessed the capability of ex vivo expanded cytokine-induced killer cells to lyse both alveolar and embryonic rhabdomyosarcoma cell lines ...
H. Kreyenberg, Gerrit Weber, S. Kloss, Bader, Peter, Koscielniak, Ewa, A. Willasch, Selim Kuci, T. Klingebiel, E. Koscielniak, Laer, Dorothee von, Miriam Stais, Willasch, Andre Manfred, D. von Laer, Klingebiel, Thomas, Klöß, Stephan, Stais, Miriam, Kuçi, Selim, Peter Bader, Eva Rettinger, Thomas Klingebiel, B. Voss, Z. Kuci, Kreyenberg, Hermann, Stephan Klöss, G. Weber, Dorothee Von Laer, E. Rettinger, Zyrafete Kuci, Kuçi, Zyrafete, Rettinger, Eva, Bernhard Voss, M. Stais, P. Bader, Hermann Kreyenberg, Weber, Gerrit, Voß, Bernhard, Ewa Koscielniak, Andre Willasch, S. Kuci   +38 more
core   +1 more source

Predominant utilization of V beta 8+ T cell receptor genes in the H-2Ld- restricted cytotoxic T cell response against the immediate-early protein pp89 of the murine cytomegalovirus [PDF]

, 1989
Cytotoxic T cell responses to the murine Cytomegalovirus (MCMV) were elicited in BALB/c mice (H-2d) by infectious virus. Eight days after infection, MCMV-primed local lymph node T cells were either depleted for T cells expressing a V beta 8+ TCR or ...
Eichmann, K., Roedewald, H. R., Koszinowski, Ulrich H., Melchers, I.   +3 more
core   +1 more source

Role of tumor architecture in elicitation of effector functions of human cytotoxic T-lymphocytes recognizing melanoma associated antigens [PDF]

, 2006
Growth in 3D architectures has been shown to promote the resistance of cancers to treatment with drugs, cytokines, or irradiation, thereby potentially playing an important role in tumor expansion.
Ghosh, Sourabh
core   +1 more source

De Novo generation of escape Variant-specific CD8+ T-Cell responses following Cytotoxic T-Lymphocyte escape in chronic Human Immunodeficiency Virus Type 1 Infection [PDF]

, 2005
Human immunodeficiency virus type 1 (HIV-1) evades CD8+ T-cell responses through mutations within targeted epitopes, but little is known regarding its ability to generate de novo CD8+ T-cell responses to such mutants.
Allgaier, R.L., Cheng, M., Galit Alter, Altfeld, M., Elizabeth T. Kalife, Frahm, N., Xu G. Yu, Kalife, E.T., Marcus Altfeld, Michael Cheng, Yu, X.G., Walker, B.D., Laura L. Reyor, Mui, S., Allen, T.M., Reyor, L.L., Christian Brander, Alter, G., Mathias Lichterfeld, Eric S. Rosenberg, Rachel L. Allgaier, Todd M. Allen, Simon A. Mallal, Nancy V. Brown, John, M., Nicole Frahm, Johnston, M.N., Rosenberg, E.S., Brown, N.V., Brander, C., Bruce D. Walker, Mina John, Mary N. Johnston, Mallal, S.A., Stanley Mui, Lichterfeld, M.   +35 more
core   +1 more source

Type I IFNs contribute to upregulation of PD-L1 during Chlamydia trachomatis infection

Infection and Immunity
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that if left untreated can cause reproductive harm. Failure of natural adaptive immunity results in chronic and repeat infections.
Nicole V. Reinhold-Larsson, Michael N. Starnbach   +1 more
doaj   +1 more source

CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen:Implications for parasite strain-specific immunity [PDF]

, 2009
Although immunodominance of CD8(+) T-cell responses is a well-recognised feature of viral infections, its role in responses to more antigenically complex pathogens is less clear.
Connelley, T., Burrells, A, W. Ivan Morrison, Declan J. McKeever, Connelley, Timothy, Taracha, Evans L., Connelly, T, McKeever, DJ, Morrison, WI, Simon P. Graham, Burrells, A., MacHugh, ND, McKeever, D J, Taracha, E.L.N., Niall D. MacHugh, Roger Pelle, Ellis, SA, McKeever, Declan J., MacHugh, N D, Connelley, T, Evans L. Taracha, Ellis, S A, Graham, SP, Pelle, Roger, Ellis, Shirley A., MacHugh, Niall D., Formisano, Principia, Formisano, P, Principia Formisano, Taracha, EL, Ellis, S.A., Shirley A. Ellis, Taracha, E L, Alison Burrells, Pelle, R, IAH, Graham, Simon P., Graham, S P, Timothy Connelley, Formisano, P., Royal (Dick) School of Veterinary Studies, ILRI, Morrison, W. Ivan, Burrells, Alison, Graham, S.P.   +44 more
core   +1 more source

Distinct cytotoxic cell subsets underlie protective and non-protective immunity to African swine fever virus

Emerging Microbes and Infections
Limited understanding of African swine fever (ASF) immunity remains a major barrier to the rational development of safe and effective vaccines. While antibody-mediated protection is still poorly defined, growing evidence highlights a central role for ...
David Marín-Moraleda, Aida Tort-Miró, Enrique Ezcurra, Sergio Montaner-Tarbes, Jordana Muñoz-Basagoiti, Elena Coatu, María Jesús Navas, Marta Muñoz, Paula Monleon, Judith González-Oliver, Lola Pailler-García, Sonia Pina-Pedrero, Francesc Accensi, Fernando Rodríguez, Jordi Argilaguet   +14 more
doaj   +1 more source

CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival. [PDF]

, 2013
CD160 is a cell surface molecule expressed by most NK cells and approximately 50% of CD8(+) cytotoxic T lymphocytes. Engagement of CD160 by MHC class-I directly triggers a costimulatory signal to TCR-induced proliferation, cytokine production and ...
Freeman, Gordon, T. Ueno, P. Fiorina, Baogong Zhu (399443), B. Zhu, Sayegh, Mohamed, Mohammed Javeed I. Ansari (399445), Antje Habicht (367049), A. Habicht, D'Addio, Francesca, Baogong Zhu, G. J. Freeman, Francesca D’Addio (289857), Mohammed Javeed I Ansari, Takuya Ueno (38813), Andrea Vergani (289866), Zhu, Baogong, F. D'Addio, Antje Habicht, M. H. Sayegh, Takuya Ueno, M. Clarkson, Clarkson, Michael, Habicht, Antje, D’Addio, Francesca, M. J. I. Ansari, Paolo Fiorina, Gordon J Freeman, Andrea Vergani, Mohammed Javeed, I. Ansari, Mohamed H. Sayegh (399444), Ansari, Mohammed Javeed I., Ueno, Takuya, Mohamed H Sayegh, Freeman, Gordon J., Michael Clarkson (399442), Fiorina, Paolo, Gordon J. Freeman (267166), Gordon J. Freeman, Vergani, Andrea, Mohamed H. Sayegh, Paolo Fiorina (251367), Michael Clarkson, A. Vergani, Sayegh, Mohamed H., Francesca D'Addio   +46 more
core   +2 more sources

Cytotoxic CD4⁺ T cells exhibit an immunosuppressive shift in checkpoint immunotherapy resistance in melanoma patients

Cancer Immunology, Immunotherapy
Although checkpoint immunotherapy has primarily focused on CD8⁺ T cells, emerging evidence highlights an important role for cytotoxic CD4⁺ T cells in mediating therapeutic responses.
Heekyong R. Bae, Byeongchan Son, Kyoungho Hwang, Suntae Kim, Howard A. Young, Eun-Young Kwon   +5 more
doaj   +1 more source

Cytotoxic CD4+ T Cells Drive Multiple Sclerosis Progression

Frontiers in Immunology, 2017
Multiple sclerosis (MS) is the leading cause of chronic neurological disability in young adults. The clinical disease course of MS varies greatly between individuals, with some patients progressing much more rapidly than others, making prognosis almost ...
Liesbet M. Peeters, Marjan Vanheusden, Veerle Somers, Bart Van Wijmeersch, Piet Stinissen, Bieke Broux, Niels Hellings   +6 more
doaj   +1 more source