Results 81 to 90 of about 14,427,848 (200)

Glycan targeting can recruit anti-tumor immunologic functions by lymphatic endothelium

Neoplasia: An International Journal for Oncology Research
During carcinoma progression, CD8+ T cells mediate tumor-cytolytic functions following tumor-antigen sensitization, typically by antigen cross-presenting dendritic cells.
Aditya Dash, Scott C. Johns, Chace Moleta, Elina I. Zúñiga, Mark M. Fuster   +4 more
doaj   +1 more source

Characterisation and ontogeny of natural killer cells in Xenopus laevis [PDF]

, 2002
The initial aim of the work described in this Thesis was to investigate the lymphoid organ distribution, phenotype and function of the lymphocyte population identified by candidate anti-Xenopus natural killer (NK) cell monoclonal antibodies (mAb's ...
Stewart, Rebecca
core  

Cytotoxic Responses Mediated by NK Cells and Cytotoxic T Lymphocytes in Xenotransplantation

Transplant International
Xenotransplantation represents a potential solution to the shortage of organs for transplantation. The recent advancements in porcine genetic modification have addressed hyperacute and acute vascular rejection; however, challenges persist with regard to ...
Viktoriia Galdina, Gisella L. Puga Yung, Jörg D. Seebach   +2 more
doaj   +1 more source

Smad7 is a negative regulator of immunogenic cell death in colorectal cancer

OncoImmunology
Induction of endoplasmic reticulum (ER) stress is followed by exposure of calreticulin (CRT) on the cancer cell plasma membrane and elicits an anticancer immune response, referred to as immunogenic cell death (ICD).
Claudia Maresca, Eleonora Franzè, Federica Laudisi, Marco Colella, Andrea Iannucci, Rachele Frascatani, Ivan Monteleone, Carmine Stolfi, Giovanni Monteleone   +8 more
doaj   +1 more source

Comparison of HIV-1 specific T cell immunity in the female genital tract and blood of HIV-infected women : impact of in vitro T cell expansion on HIV-specific T cell specificity, maturational status and functional complexity [PDF]

, 2010
Includes bibliographical references (leaves 161-184).This study shows that HIV-specific cervical T cells can be isolated by cytobrushing and in vitro polyclonal expansion is a useful approach to increase the number of T cells available from mucosal sites.
Bere, Alfred
core   +1 more source

CX3CR1+ age-associated CD4+ T cells contribute to synovial inflammation in late-onset rheumatoid arthritis

Inflammation and Regeneration
Background Recent evidence suggests that clonally expanded cytotoxic T cells play a role in various autoimmune diseases. Late-onset rheumatoid arthritis (LORA) exhibits unique characteristics compared to other RA forms, suggesting distinct immunological ...
Mitsuhiro Akiyama, Sohma Wakasugi, Keiko Yoshimoto, Koichi Saito, Sho Ishigaki, Risa Inukai, Yoshiyuki Matsuno, Waleed Alshehri, Yasushi Kondo, Yuko Kaneko   +9 more
doaj   +1 more source

Lesional senescent CD4+ T cells mediate bystander cytolysis and contribute to the skin pathology of human cutaneous leishmaniasis

Frontiers in Immunology
Cytotoxic activity is a hallmark of the immunopathogenesis in human cutaneous leishmaniasis (CL). In this study, we identified accumulation of CD4+ granzyme B producing T cells with increased cytotoxic capacity in CL lesions.
Luciana Polaco Covre, Luciana Polaco Covre, Luciana Polaco Covre, Carlos Henrique Fantecelle, Renan Garcia de Moura, Paola Oliveira Lopes, Isabela Valim Sarmento, Celio Geraldo Freire-de-Lima, Debora Decote-Ricardo, Herbert Leonel de Matos Guedes, Herbert Leonel de Matos Guedes, Alessandra Marcia da Fonsceca-Martins, Lucas Pedreira de Carvalho, Edgar Marcelino de Carvalho, David M. Mosser, Aloisio Falqueto, Arne N. Akbar, Daniel Claudio Oliveira Gomes, Daniel Claudio Oliveira Gomes   +18 more
doaj   +1 more source

Anti‐tumour activity and store operated calcium entry: new roles in immunology

EMBO Molecular Medicine, 2013
Kavisha Singh, Paul Rosenberg
doaj   +1 more source

Editorial: Cytotoxic CD4+ T Cells in Viral Infections

Frontiers in Immunology, 2017
Chansavath Phetsouphanh, Shiv Pillai, John J. Zaunders, John J. Zaunders   +3 more
doaj   +1 more source

A CD57+CD8+ T cell subset links T cell cytotoxicity to fibrotic lung disease in systemic sclerosis

The Journal of Clinical Investigation
Interstitial lung disease (ILD) is a major cause of morbidity and mortality in systemic sclerosis (SSc); however, the immunopathologic mechanisms driving lung disease in SSc are unclear.
Takanori Sasaki, Ye Cao, John M. Sowerby, Kazuhiko Higashioka, Kathryne E. Marks, Mehreen Elahee, Mari Kamiya, Paul F. Dellaripa, Richard I. Ainsworth, Kimberly E. Taylor, Nunzio Bottini, Paul Wolters, Edy Y. Kim, Francesco Boin, Deepak A. Rao   +14 more
doaj   +1 more source