Results 31 to 40 of about 2,965,907 (391)

A20 controls macrophage to elicit potent cytotoxic CD4(+) T cell response. [PDF]

PLoS ONE, 2012
Emerging evidence indicates that CD4(+) T cells possess cytotoxic potential for tumor eradication and perforin/granzyme-mediated cytotoxicity functions as one of the important mechanisms for CD4(+) T cell-triggered cell killing.
Lifeng Wang, Bangxing Hong, Xiaoxia Jiang, Lindsey Jones, Si-Yi Chen, Xue F Huang   +5 more
doaj   +1 more source

Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks [PDF]

, 2014
The focus of the present study was to characterize the phosphoproteome of cytotoxic T cells and to explore the role of the serine threonine kinase PKD2 (Protein Kinase D2) in the phosphorylation networks of this key lymphocyte population.
Azzam, Balagopalan, Beadling, Caenepeel, Chiang, Cornish, Cox, Cox, Dequiedt, Doreen A. Cantrell, Döppler, Eggers, Eiseler, Eiseler, Flotho, Franz-Wachtel, Fugmann, Grønborg, Hao, Hardie, Hausser, Hay, Huang, Hunter, Hutti, Huttlin, Jens L. Hukelmann, Juergen Goebel, Kajiho, Kalia, Kitao, Komander, Larghi, Malek, Marklund, María N. Navarro, Matthews, Matthews, Matthews, Mayya, Navarro, Navarro, Ng, Nhek, Nishikawa, Olayioye, Parra, Parra, Peterburs, Pipkin, Rey, Rozengurt, Ruperez, Seaman, Sinclair, Soares, Spitaler, Spratley, Tamas, Urso, Vizcaíno, Wang, Wang, Waugh, Weninger, Wood, Zarrouk, Zhou, Ziegler   +68 more
core   +3 more sources

Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells. [PDF]

, 2014
Prostaglandin E2 (PGE2), a pleiotropic immunomodulatory molecule, and its free radical catalyzed isoform, iso-PGE2, are frequently elevated in the context of cancer and chronic infection.
Chou, Jennifer P, Effros, Rita B, Koduri, Megha P, Ramirez, Christina M, Ryba, Danielle M   +4 more
core   +2 more sources

Antigen presenting capacity of murine splenic myeloid cells [PDF]

, 2017
BACKGROUND: The spleen is an important site for hematopoiesis. It supports development of myeloid cells from bone marrow-derived precursors entering from blood. Myeloid subsets in spleen are not well characterised although dendritic cell (DC) subsets are
Hey, Ying-Ying, O'Neill, Helen C, Quah, Benjamin   +2 more
core   +2 more sources

Vaccination with Mage-3a1 Peptide–Pulsed Mature, Monocyte-Derived Dendritic Cells Expands Specific Cytotoxic T Cells and Induces Regression of Some Metastases in Advanced Stage IV Melanoma

Journal of Experimental Medicine, 1999
Dendritic cells (DCs) are considered to be promising adjuvants for inducing immunity to cancer. We used mature, monocyte-derived DCs to elicit resistance to malignant melanoma. The DCs were pulsed with Mage-3A1 tumor peptide and a recall antigen, tetanus
B. Thurner, I. Haendle, C. Röder, D. Dieckmann, P. Keikavoussi, H. Jonuleit, A. Bender, C. Maczek, D. Schreiner, P. von den Driesch, E. Bröcker, R. Steinman, A. Enk, E. Kämpgen, G. Schuler   +14 more
semanticscholar   +1 more source

Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection. [PDF]

, 2017
The gastrointestinal mucosa is an important site of HIV acquisition, viral replication, and pathogenesis. Immune cells in mucosal tissues frequently differ in phenotype and function from their non-mucosal counterparts.
Critchfield, JW, Deeks, SG, Ganesh, A, Hecht, FM, Hunt, PW, Kiniry, BE, Shacklett, BL, Somsouk, M   +7 more
core   +1 more source

Methods and compositions for stimulating T-lymphocytes [PDF]

, 2003
Disclosed are methods, compositions, antibodies, and therapeutic kits for use in stimulating cytotoxic T-lymphocytes and generating immune responses against epitopes of protooncogenes.
Fisk, Bryan A., Ioannides, Constantin G., Ioannides, Maria G.   +2 more
core   +1 more source

Adjuvant activity of ethanol extract of Hippophae rhamnoides leaves with inactivated rabies virus antigen

Pharmaceutical Biology, 2018
Context: Hippophae rhamnoides L. (Elaeagnaceae), commonly known as seabuckthorn (SBT), is known for its medicinal and nutritional properties. Objective: Evaluation of in vivo adjuvant activity of SBT leaf extract (SBTE) with inactivated rabies virus ...
D. Singh, B. Jayashankar, K. P. Mishra, H. Tanwar, S. N. Madhusudana, A. Y. Belludi, R. Tulsawani, S. B. Singh, L. Ganju   +8 more
doaj   +1 more source

Regulatory T-Cells Suppress Cytotoxic T Lymphocyte Responses against Microglia

Cells, 2022
Regulatory T-cells (Tregs) play pivotal roles during infection, cancer, and autoimmunity. In our previous study, we demonstrated a role for the PD-1:PD-L1 pathway in controlling cytolytic responses of CD8+ T lymphocytes against microglial cells ...
Priyanka Chauhan, Shuxian Hu, Wen S. Sheng, James R. Lokensgard   +3 more
doaj   +1 more source

Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1. [PDF]

, 2017
The expansion of CD8+CD28- T cells, a population of terminally differentiated memory T cells, is one of the most consistent immunological changes in humans during aging.
Fei, Mingjian, Gordon, David E, Hull, Philip A, Jeng, Mark Y, Johnson, Jeffrey, Kasler, Herb, Krogan, Nevan, Kwon, Hye-Sook, Ng, Che-Ping, Ott, Melanie, Tsou, Chia-Lin, Verdin, Eric   +11 more
core   +1 more source