Generation of Cytotoxic T Cells and Dysfunctional CD8 T Cells in Severe COVID-19 Patients
Cells, 2022 COVID-19, the infectious disease caused by SARS-CoV-2, has spread on a pandemic scale. The viral infection can evolve asymptomatically or can generate severe symptoms, influenced by the presence of comorbidities.
Sarah Cristina Gozzi-Silva +15 more
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Journal of Immunology Research, 2022 Background. Neoadjuvant immunotherapy is promising for locally advanced non-small-cell lung cancer (NSCLC). The in situ immune patterns, as a predictor of PD-1/PD-L1 blockade outcomes, of the primary tumor (PT) and metastatic lymph nodes (mLNs) are ...
Zheng-Hao Ye, Hao Long, Ze-Rui Zhao
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T cell-specific suppressor factor(s) with regulatory influence on interleukin 2 production and function [PDF]
, 1982 In this study we report that alloantigen-activated spleen cells produce both amplifying and suppressive factors under the same conditions. Both types of soluble mediators--as detected in different assay systems-- were present in the supernatants of in ...
Michael Kramer +3 more
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How Reliable Are Predictions of CD8+ T Cell Epitope Recognition? Lessons for Cancer
OncoSynthetic peptides derived from antigen sequences are essential reagents for the detection of CD8+ cytotoxic T lymphocytes (CTLs), in assays such as ELISPOT/ImmunoSpot®.
Alexander A. Lehmann +2 more
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Cancer Medicine, 2023 Background Functional status of T cells determines the responsiveness of cancer patients to immunotherapeutic interventions. Even though T cell‐mediated immunity is inaugurated in the tumor‐adjacent lymph nodes, peripheral blood has been routinely ...
Izel Yilmaz +7 more
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Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva [PDF]
, 1995 Class I major histocompatibility complex-restricted parasite-specific cytotoxic T lymphocytes (CTL) are known to be a major component of the bovine immune response to the protozoan parasite Theileria parva, but formal proof for their role in protection ...
Goddeeris, Bruno +3 more
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Interleukin-10 containing normal human serum inhibits granzyme B release but not perforin release from alloreactive and EBV-specific T cell clones [PDF]
, 2007 Interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor, has pleiotropic effects in immunoregulation and inflammation. It is capable of inhibiting synthesis of pro-inflammatory cytokines like interferon [gamma] (IFN[gamma]), IL-2, IL-3,
Kenji Tadokoro +4 more
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T-Cell Stimulation by Melanoma RNA-Pulsed Dendritic Cells [PDF]
, 2004 In situations where well-established approaches such as surgery, radiation therapy and chemotherapy fail to help cancer patients, immunotherapy has the potential to be an effective alternative.
Javorovic, Miran
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Next-Generation Immunotherapies to Improve Anticancer Immunity
Frontiers in Pharmacology, 2021 Checkpoint inhibitors are widely used immunotherapies for advanced cancer. Nonetheless, checkpoint inhibitors have a relatively low response rate, work in a limited range of cancers, and have some unignorable side effects.
Yaoyao Shi +5 more
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Theileria annulata and T. parva infect and transform different bovine mononuclear cells [PDF]
, 1989 Bovine peripheral blood mononuclear cells (PBMC) were labelled with monoclonal antibodies recognizing bovine MHC class II, sIgM, monocyte, T-helper and T-cytotoxic cell phenotypes.
Brown, C G +3 more
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