Results 11 to 20 of about 2,965,907 (391)

Cytotoxic T cells swarm by homotypic chemokine signalling

eLife, 2020
Cytotoxic T lymphocytes (CTLs) are thought to arrive at target sites either via random search or following signals by other leukocytes. Here, we reveal independent emergent behaviour in CTL populations attacking tumour masses.
Jorge Luis Galeano Niño, Sophie V Pageon, Szun S Tay, Feyza Colakoglu, Daryan Kempe, Jack Hywood, Jessica K Mazalo, James Cremasco, Matt A Govendir, Laura F Dagley, Kenneth Hsu, Simone Rizzetto, Jerzy Zieba, Gregory Rice, Victoria Prior, Geraldine M O'Neill, Richard J Williams, David R Nisbet, Belinda Kramer, Andrew I Webb, Fabio Luciani, Mark N Read, Maté Biro   +22 more
doaj   +2 more sources

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity

Nature Communications, 2021
Lethal hit delivery by cytotoxic T lymphocytes (CTL) towards B lymphoma cells occurs as a binary, “yes/no” process. In non-hematologic solid tumors, however, CTL often fail to kill target cells during 1:1 conjugation.
B. Weigelin, A. D. den Boer, E. Wagena, K. Broen, H. Dolstra, Rob J. de Boer, C. Figdor, J. Textor, P. Friedl   +8 more
semanticscholar   +1 more source

Single-cell metabolic profiling of human cytotoxic T cells

Nature Biotechnology, 2020
Cellular metabolism regulates immune cell activation, differentiation and effector functions, but current metabolic approaches lack single-cell resolution and simultaneous characterization of cellular phenotype. In this study, we developed an approach to
F. Hartmann, Dunja Mrdjen, E. Mccaffrey, David R. Glass, N. Greenwald, Anusha Bharadwaj, Zumana Khair, S. Verberk, Alex Baranski, Reema Baskar, William Graf, David Van Valen, J. van den Bossche, Michael Angelo, S. Bendall   +14 more
semanticscholar   +1 more source

The effect of SMAD4 on the prognosis and immune response in hypopharyngeal carcinoma

Frontiers in Medicine, 2023
ObjectivesIn malignant tumors, elevated infiltration of intratumoral CD8+ cytotoxic T cells predicts a beneficial prognosis, whereas high levels of CD15+ neutrophils in peritumor tissues indicate poor prognosis.
Juanjuan Song, Jialing Wu, Jiaxuan Ding, Yangxin Liang, Changlong Chen, Yimin Liu   +5 more
doaj   +1 more source

Supramolecular attack particles are autonomous killing entities released from cytotoxic T-cells

Science, 2020
Supramolecular attack particles Cytotoxic T cells (CTLs) are at the front lines against cancer and chronic infection. T cells kill by secreting caspase-activating granzymes and the pore-forming protein perforin from dense core granules.
Š. Bálint, S. Müller, R. Fischer, B. Kessler, M. Harkiolaki, S. Valitutti, Michael Loran Dustin   +6 more
semanticscholar   +1 more source

Features of T lymphocyte subpopulation profile in patients with ankylosing spondylitis undergoing genetically engineered biological therapy

Медицинская иммунология, 2021
The aim of current study was to compare profiles of T cell subsets in the patients with ankylosing spondylitis (AS) who received different modes of genetically engineered biological therapy (GEBT).
A. A. Savchenko, O. D. Gritsenko, A. G. Borisov, I. V. Kudryavtsev, M. K. Serebriakova, A. A. Masterova, P. A. Shesternya   +6 more
doaj   +1 more source

Cytotoxic CD4 T cells in the mucosa and in cancer

Frontiers in Immunology, 2023
CD4 T cells were initially described as helper cells that promote either the cellular immune response (Th1 cells) or the humoral immune response (Th2 cells).
Hrishi Venkatesh, Hrishi Venkatesh, Sean I. Tracy, Sean I. Tracy, Michael A. Farrar, Michael A. Farrar   +5 more
doaj   +1 more source

Generation of virus-specific cytotoxic T cells in vitro I. Induction conditions of primary and secondary Sendai virus-specific cytotoxic T cells [PDF]

, 1979
H-2-restricted cytotoxic T cells specific for Sendai virus were generated in vitro in a primary response from normal mouse lymphocytes cultured in the presence of infective as well as inactivated Sendai virus. Antigen-presenting cells of different origin,
Andersson, Burakoff, Butchko, Cantor, Cantor, Cerottini, Cerottini, Dunlop, Engers, Engers, Ennis, Ertl, Ertl, Finberg, Gething, Hapel, Hayry, Julius, Jung, Kessel, Kirchner, Koszinowski, Koszinowski, Koszinowski, Lafferty, Levy, Lightbody, McKenzie, Palmer, Parker, Pfitzenmaier, Plate, Röllinghoff, Schrader, Shen, Simon, Wagner, Wagner, Wiktor, Zinkernagel, Zinkernagel, Zweerinck   +41 more
core   +1 more source

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

Journal of Experimental Medicine, 2000
This report shows that cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) plays a key role in T cell–mediated dominant immunologic self-tolerance.
Takeshi Takahashi, Tomoyuki Tagami, S. Yamazaki, T. Uede, J. Shimizu, N. Sakaguchi, T. Mak, S. Sakaguchi   +7 more
semanticscholar   +1 more source

Fighting viral infections and virus-driven tumors with cytotoxic CD4+ T cells [PDF]

, 2017
CD4+ T cells have been and are still largely regarded as the orchestrators of immune responses, being able to differentiate into distinct T helper cell populations based on differentiation signals, transcription factor expression, cytokine secretion, and
Adhikary, Adhikary, Adhikary, Ahn, Anderson, Annunziato, Appay, Appay, Aslan, Balfour, Battaglia, Baumjohann, Bickham, Bosselut, Britt, Brown, Brown, Brown, Brown, Brown, Bui, Cao, Cao, Cao, Carpenter, Casazza, Chen, Cheroutre, Chiu, Coler, de Souza, Deligeoroglou, Demachi-Okamura, Depil, Devarajan, Di Mitri, Dillon, Draenert, Duftner, Dumitriu, Endo, Enssle, Eshima, Facchinetti, Farrar, Faè, Fishman, Fleischer, Fontenot, Freeman, Fu, Fu, Gamadia, Gao, Garcia-Chagollan, Gasser, Geginat, Gelband, Goonetilleke, Grabowska, Grakoui, Grant, Grant, Groh, Ha, Haigh, Haque, Heaton, Hegde, Heller, Heusinkveld, Hildemann, Hislop, Hohler, Homma, Houser, Hua, Huz, Icheva, James, Jameson, Jeitziner, Johnson, Jones, Jones, Jonjic, Kadish, Kannanganat, Kaufmann, Kayagaki, Kenter, Kenter, Khanolkar, King, King, Kobayashi, Koel, Krensky, Kroesen, Kruger, Kuroda, Lazdina, Li, Libri, Lin, Loewendorf, Long, Long, Long, Long, Luckheeram, Lunemann, MacArthur, Mackay, Magnani, Malnati, Man, Manzke, Marshall, Martorelli, Mattapallil, McKinstry, McMichael, Merlo, Merlo, Metkar, Miamen, Moormann, Morales, Mosmann, Mucida, Munz, Munz, Murphy, Musey, Namekawa, Nemes, Nikiforow, Nixon, Norris, Oestreich, Omiya, O’Shea, Pachnio, Pachnio, Paludan, Pender, Peng, Penna, Piriou, Plata, Porakishvili, Qui, Quigley, Ratto-Kim, Reis, Rentenaar, Rerks-Ngarm, Ressing, Rosenberg, Sacha, Sakaguchi, Sallusto, Sandbulte, Savic, Scherrenburg, Schueller, Schulze zur Wiesch, Schulze Zur Wiesch, Schwartz, Seresini, Seresini, Soghoian, Soghoian, Spaete, Stacey, Steele, Streeck, Stuller, Su, Sun, Tagawa, Takeuchi, Tenzer, Terahara, Tewari, Thursz, Todryk, Tong, Toussirot, Trautmann, Trautmann, Trifari, Tscharke, Turnbull, Ulsenheimer, Vacchio, van de Berg, van den Hende, van Leeuwen, Vasin, Veldhoen, Ventura, Verma, Veronese, Voo, Voo, Vossen, Walker, Walton, Wang, Wang, Welters, Welters, WHO, Wilkinson, Wilson, Wilson, Wintermeyer, Workman, Xie, Xue, Yan, Yewdell, Zaunders, Zaunders, Zheng, Zhou, Zuo, zur Hausen   +229 more
core   +2 more sources