Results 11 to 20 of about 15,530,977 (295)

Comparative Analysis of Extracellular Vesicles from Cytotoxic CD8⁺ αβ T Cells and γδ T Cells

Cells
Background: Although belonging to different branches of the immune system, cytotoxic CD8+ αβ T cells and γδ T cells utilize common cytolytic effectors including FasL, granzymes, perforin and granulysin.
Lisa Griesel, Patrick Kaleja, Andreas Tholey, Marcus Lettau, Ottmar Janssen   +4 more
doaj   +2 more sources

Cytotoxic T Cells [PDF]

Journal of Investigative Dermatology, 2006
The immune system is a complex arrangement of cells and molecules that preserve the integrity of the organism by elimination of all elements judged dangerous. Within the immune system, a humoral and a cellular as well as an innate and an adaptive arm can be differentiated.
Andersen, Mads Hald, Schrama, David, thor Straten, Per, Becker, Jürgen C.   +3 more
  +7 more sources

Cytotoxic T cells and mycobacteria [PDF]

FEMS Microbiology Letters, 2001
How the immune system kills Mycobacterium tuberculosis is still a puzzle. The classical picture of killing due to phagocytosis by activated macrophages may be only partly correct. Based on recent evidence, we express here the view that cytotoxic T lymphocytes also make an important contribution and suggest that DNA vaccines might be a good way to ...
C L, Silva, V L, Bonato, K M, Lima, A A, Coelho-Castelo, L H, Faccioli, A, Sartori, A O, De Souza, S C, Leão   +7 more
openaire   +2 more sources

Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific [PDF]

, 1998
Acute HIV infection is associated with a vigorous immune response characterized by the proliferation of selected T cell receptor V beta (BV)-expressing CD8(+) T cells.
Ogg, GS, Christopher A. O'Callaghan, Philip J.R. Goulder, O'Callaghan, CA, Allen, RL, Anthony Kelleher, Andy K. Sewell, Jamie D.K. Wilson, Kelleher, A, Goulder, PJ, Andrew J. McMichael, Graham S. Ogg, Rachel L. Allen, Rowland-Jones, SL, Callan, MF, Wilson, JD, Sarah L. Rowland-Jones, Margaret F.C. Callan, Sewell, AK, McMichael, AJ   +19 more
core   +1 more source

Distinct Roles of Vav Family Members in Adaptive and Innate Immune Models of Arthritis

Biomedicines, 2021
Genetic evidence suggests that three members of the VAV family (VAV1, VAV2 and VAV3) of signal transduction proteins could play important roles in rheumatoid arthritis.
Javier Conde, Isabel Fernández-Pisonero, Myriam Cuadrado, Antonio Abad, Javier Robles-Valero, Xosé R. Bustelo   +5 more
doaj   +1 more source

The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo [PDF]

, 2005
Background The integrin CD11c is known as a marker for dendritic cells and has recently been described on T cells following lymphotropic choriomeningitis virus infection, a systemic infection affecting a multitude of organs.
Nina Peters, Doths, Sandra, Peter JM Openshaw, Jürgen Schwarze, Openshaw, Peter J M, Wang, HW, Peters, N, Wang Hongwei, Koerner-Rettberg, C, Schwarze Jürgen, Beyer, Marc, Koerner-Rettberg, Cordula, Beyer Marc, Openshaw Peter JM, Marc Beyer, Koerner-Rettberg Cordula, Schwarze, J, Cordula Koerner-Rettberg, Doths, S, Peters Nina, Doths Sandra, Beyer, M, Hongwei Wang, Schwarze, Jürgen, Openshaw, PJ, Peters, Nina, Sandra Doths, Wang, Hongwei   +27 more
core   +2 more sources

The role of cytokines, coagulation and fibrinolysis in leucocyte and LAK cell cytotoxicity of tumour cells [PDF]

, 2012
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Interleukin-2 activates lymphocytes to become highly cytotoxic for a wide range of tumour cell types in vitro (Iymphokine activated killer or LAK cells ...
Biggerstaff, John
core   +7 more sources

Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks [PDF]

, 2014
The focus of the present study was to characterize the phosphoproteome of cytotoxic T cells and to explore the role of the serine threonine kinase PKD2 (Protein Kinase D2) in the phosphorylation networks of this key lymphocyte population.
Goebel, Juergen, Hukelmann, Jens L., Cantrell, Doreen A., Navarro, Maria N.   +3 more
core   +1 more source

Maintenance of Functional CD57+ Cytolytic CD4+ T Cells in HIV+ Elite Controllers

Frontiers in Immunology, 2019
Cytolytic CD4+ T cells play a prominent role in chronic viral infection. CD4+ CTLs clones specific for HIV-1 Nef and Gag are capable of killing HIV-1 infected CD4+ T cells and macrophages.
Chansavath Phetsouphanh, Daniel Aldridge, Emanuele Marchi, C. Mee Ling Munier, Jodi Meyerowitz, Lyle Murray, Cloete Van Vuuren, Dominique Goedhals, Sarah Fidler, Anthony Kelleher, Paul Klenerman, John Frater   +11 more
doaj   +1 more source

Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein [PDF]

, 2001
The BCR-ABL oncogene is central in the pathogenesis of chronic myeloid leukemia (CML). Here, tandem nanospray mass spectrometry was used to demonstrate cell surface HLA- associated expression of the BCR-ABL peptide KQSSKALQR on class I-negative CIVIL ...
Lill, JR, Christmas, SE, Wang, LH, Macintyre, AR, Bourdon, A, Hill, SC, Rojas, J, Dodi, IA, Bonner, PLR, Aubert, G, Creaser, CS, Clark, RE, Rees, RC, Travers, PJ, Madrigal, JA   +14 more
core   +1 more source