Results 251 to 260 of about 629,825 (307)

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Splenic cDC1 efferocytosis and cross-presentation to CD8 T cells are promoted by GPR34 and lysophosphatidylserine. [PDF]

J Exp Med
Tam H, Shen H, Xu Y, An J, Cyster JG.
europepmc   +1 more source

High baseline PD-1+ CD8 T Cells and TIGIT+ CD8 T Cells in circulation associated with response to PD-1 blockade in patients with non-small cell lung cancer. [PDF]

Cancer Immunol Immunother
Dutta N, Svensson J, Saad GA, Mello M, Eklund EA, Altinönder I, Torstensson P, Sayin VI, Rohlin A, Luche H, Hallqvist A, Raghavan S.   +11 more
europepmc   +1 more source

Brain-infiltrating CD8 T cells retain functional activity to protect against acute Zika virus infection. [PDF]

Sci Rep
Kim J, Lee W, Kim DY, Ku KB, Kwon YC, Kim KD, Kim C, Ahn DG, Kim SJ, Park S.   +9 more
europepmc   +1 more source

CD4+ and CD8+ T cells are not the main driver of Lassa fever pathogenesis in macaques. [PDF]

JCI Insight
Prévost J, Tailor N, Soule G, Audet J, Deschambault Y, Vendramelli R, Prado-Smith J, Tierney K, Azaransky K, Kobasa D, Clancy CS, Feldmann H, Rosenke K, Safronetz D.   +13 more
europepmc   +1 more source

Dietary conjugated linoleic acid enhances resistance to <i>Salmonella</i> infection by promoting PPARγ-mediated metabolic reprogramming and effector function in CD8⁺ T cells. [PDF]

Gut Microbes
Deng L, Wang X, Mebratie DY, Tang Y, Hu J, Qi J, Tian M, Bao Y, Zhu L, Wang S.   +9 more
europepmc   +1 more source

XCR1+ and CD11b+ migratory dendritic cells cooperate for the cross-priming of intratumoral CD8+ T cells with a tissue-resident memory phenotype.

Guermonprez P, Vaudiau N, Bourdely P, Ok A, Semitekolou M, Gorline L, Savoldelli R, Gerber-Ferder Y, Carmo FD, Sémervil A, Vetillard M, Rood A, Bouallègue S, Pamboukas K, Bornères J, Darrasse-Jeze G, Gautier E, Dalod M, TARTOUR E, Bergsbaken T, Gisbergen Kv, Hodivala-Dilke K, Saveanu L, Helft J, Benvenuti F, Coulibaly A, Rastello M, Guillin M, Weber J, Abbas A, Garcia Z, Ginhoux F, Bleriot C, Bousso P, Kumamoto Y, Mazzone M.   +35 more
europepmc   +1 more source

Correction: Macrophage CCL7 promotes resistance to immunotherapy for colorectal cancer by regulating the infiltration of macrophages and CD8+ T cells. [PDF]

J Immunother Cancer
europepmc   +1 more source

Differential regulation of TCR-induced ZFP36 and ZFP36L1 expression by cyclosporin A in CD8+ T cells

Evans MJ, Mitchell TJ, Zaucha M, Petkau G, Turner M.   +4 more
europepmc   +1 more source