Results 201 to 210 of about 410,654 (263)

CXCL13-expressing CD4⁺ T cells coordinate the lymphocytes triad to promote the anti-tumor immunity in NSCLC. [PDF]

Oncoimmunology
Liu D, Luo J, Guo W, Ma J, Yang X, Xia Y, Li P, Xu D, Gu Z.   +8 more
europepmc   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Artificial Host‐Guest Recognition Directs Glycometabolically Engineered Macrophages to Tumors

Advanced Science, EarlyView.
Glycoengineered supramolecular macrophages (GSAR‐M) are developed using glycometabolic labeling for bioorthogonal host‐guest tumor targeting. This engineering approach unexpectedly enhances macrophage migration, phagocytosis, and pseudopodia formation. Consequently, GSAR‐M demonstrate robust tumor‐targeting specificity, effectively arrest tumor growth,
Zhiqing Yang, Qian Cheng, Ziyi Wang, Jianwen Wei, Qun Guan, Huazhong Yu, Qingwen Zhang, Caixia Yin, Ruibing Wang   +8 more
wiley   +1 more source

Protocol for co-culture of murine bone marrow-derived dendritic cells with OT-I mouse CD8⁺ T cells to evaluate immune activation efficacy. [PDF]

STAR Protoc
Jiang M, Matzek D, Nguyen A, Popper B, Merkel OM.   +4 more
europepmc   +1 more source

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

Early sex-related transcriptional differences in CD8⁺ T cells responding to chronic viral infection reveal a sex bias in exhaustion. [PDF]

Front Immunol
Kahia N, Robertson SM, Rodriguez M, Layug PJ, Vats H, Kannan K, Spicer V, Ozturk-Aptekmann A, Wilkins O, Arsenio J.   +9 more
europepmc   +1 more source

Beyond CD4: Posterior segment findings and virologic-immunologic predictors in highly active antiretroviral therapy-naïve HIV patients. [PDF]

Indian J Ophthalmol
Hayat SC, Yilmaz YC, Gunduz A, Uran M, Ozal SA.   +4 more
europepmc   +1 more source

The Memory Inflation Response Against Spread-Defective CMV Requires Priming-Independent CD4⁺ T Cell Help. [PDF]

Eur J Immunol
Barton J, Kim Y, Warkotsch MT, Cicin-Sain L, Poltorak MP, Buchholz VR, Busch DH.   +6 more
europepmc   +1 more source

GSK-3 regulates CD4-CD8 cooperation for super-armed CD8+ cytolytic T cells in immunotherapy against tumors. [PDF]

Signal Transduct Target Ther
Moës B, Krueger J, Liu C, Anto NP, Nemati A, Attias M, Kazanova A, Gao Y, Castoun-Puckett L, Oroya AC, Nguyen LH, Cabald AL, Tu TH, Rudd CE.   +13 more
europepmc   +1 more source

An orthotopic organoid-based model to study early CD8⁺ T cell dysfunction and immunotherapy response in colorectal cancer. [PDF]

Oncoimmunology
Lucantonio L, Schiano L, Sozio F, Kosta A, Peruzzi G, Molfetta R, Pietropaolo G, Laffranchi M, Campese AF, Bernardini G, Sozzani S, Gismondi A, Santoni A, Sciumè G, Helena S, Fionda C.   +15 more
europepmc   +1 more source