Results 281 to 290 of about 471,511 (315)

Helping the CD8+ T-cell response

Nature Reviews Immunology, 2004
Cytotoxic T lymphocytes (CTLs) that express the CD8 co-receptor are the guided missiles of the immune system. They express clonally distributed receptors for foreign antigen, undergo marked proliferation in response to infection and kill any cell that expresses their target antigen.
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Heterogeneity of CD4+ and CD8+ T cells

Current Opinion in Immunology, 2003
There is extensive plasticity in the T-cell response to antigen. Helper CD4(+) T cells, cytotoxic CD8(+) T cells, the progression from naïve to effector and memory T cells, and differentiation into Th1, Tc1, Th2 and Tc2 subsets have long been recognized.
David L, Woodland, Richard W, Dutton
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CD8+ T cells in atopic disease

Current Opinion in Immunology, 1998
In recent years there has been a tremendous expansion in our understanding about CD8(+) T cells. We now know that, as for CD4(+) T cells, they can be divided into subsets (Tc1 and Tc2) according to the cytokines they secrete. These subsets may differ in their capacity to kill and may even, in some cases, provide help for B cell antibody production or ...
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CD8+ T cell-coccidia interactions

Parasitology Today, 1994
Host responses to coccidian parasites involve many facets of the immune system, including antigen-specific as well as antigen-nonspecific components. Hyun Lillehoj and James Trout here review the evidence that cell-mediated responses are probably the main line of defense against coccidial infection.
H S, Lillehoj, J M, Trout
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Peripheral tolerance in CD8+ T cells

Cytokine, 2009
The establishment and maintenance of T cell tolerance to self- and non-pathogenic foreign antigens is critical for immune homeostasis. Thymic deletion of self-reactive T cells is an important component of tolerance, but it is incomplete, and does not establish tolerance to most foreign antigens.
Mathangi, Srinivasan, Kenneth A, Frauwirth   +1 more
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CD8+ T cells in systemic sclerosis

Immunologic Research, 2011
Systemic sclerosis (SSc) is a progressive and highly debilitating autoimmune disorder characterized by inflammation, fibrosis, and vascular damage of the connective tissue. T cell-derived cytokines have been implicated in the induction of fibrosis.
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Dynamic imaging of chemokine-dependent CD8+ T cell help for CD8+ T cell responses

Nature Immunology, 2007
Naive T lymphocytes move efficiently in lymphoid tissues while scanning dendritic cells in search of cognate complexes of peptide in major histocompatibility molecules. However, T cell migration ceases after recognition of cognate antigen. We show here that during the initiation of antigen-specific CD8(+) T cell responses, naive CD8(+) polyclonal T ...
Stéphanie, Hugues, Alix, Scholer, Alexandre, Boissonnas, Alexander, Nussbaum, Christophe, Combadière, Sebastian, Amigorena, Luc, Fetler   +6 more
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Memory CD8+ T Cell Protection

2013
Memory CD8⁺ T cells play an essential role in controlling pathogenic infections. Therefore generating protective memory CD8⁺ T cells by vaccination is an attractive strategy for preventing and treating a variety of human diseases. Understanding what comprises a protective memory CD8⁺ T cell response will help optimize vaccine-induced CD8⁺ T cell ...
Sanda, Remakus, Luis J, Sigal
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Regulators of CD8+ T cell exhaustion

Nature Reviews Immunology
T cell exhaustion is an adaptive and distinct cell fate that emerges in response to persistent antigen stimulation, primarily in chronic infections and cancer. It is characterized by a progressive loss of effector functions and sustained expression of multiple inhibitory receptors.
Qinli Sun, Chen Dong
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The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes

Cell, 2022
Qin Tian, Wei Dong, Ling Ran
exaly