Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 6, December 2026.ABSTRACT We previously developed nanobodies acting as positive allosteric modulators (PAMs) of the calcium‐sensing receptor (CaSR). Here, we sought to develop more potent CaSR modulators by creating bivalent nanobody constructs using ‘tail‐to‐head’ peptide‐linker conjugation.
Mahdis Nabipour +5 more
wiley +1 more source
Frontal Cerebral Blood Flow Deficits in Behavioral Variant Frontotemporal Dementia: Associations With Clinical Symptoms, Peripheral Vascular Biomarkers, and Neuroimaging Measures. [PDF]
CNS Neurosci TherHou J +7 more
europepmc +1 more source
Journal of Internal Medicine, Volume 300, Issue 6, Page 832-843, December 2026.. Abstract Background Liver cirrhosis is often diagnosed in working‐age adults and carries a poor prognosis. A better understanding of variation by employment status and occupation may support earlier and more targeted diagnostic evaluation. Objectives To assess the odds of liver cirrhosis across labor‐market status and occupations in working‐age ...
Marie Zalesiak +5 more
wiley +1 more source
How Experience of Online Group Polarization Relates to University Students' Value-Related Judgments and Choices: The Parallel Mediating Roles of Cognitive Dissonance and Emotional Contagion. [PDF]
Behav Sci (Basel)He S, Li J, Yang R, Wu Z, Lu H.
europepmc +1 more source
Drivers of 2024 Record Low Sea Ice in Eastern Hudson Bay: A Satellite Era Perspective
Journal of Geophysical Research: Atmospheres, Volume 131, Issue 21, 16 November 2026.Abstract By late May 2024, Hudson Bay (HB) reached record‐low sea ice extent (SIE) and sea ice concentration (SIC), which has been attributed to the persistent easterly winds in May 2024. This study further investigates the role of easterly winds as well as broader contributing factors.
Richard Dworak +4 more
wiley +1 more source
Unleashing the combined potential of bio-based carbon dioxide removal in Germany's path to net zero from the bioenergy system perspective. [PDF]
iScienceSadr M +4 more
europepmc +1 more source
International Journal of Climatology, Volume 46, Issue 13, 15 November 2026.Conceptual hydroclimatic pathway linking the concurrent negative North Atlantic Oscillation (NAO) phase and weak La Niña conditions to extreme February rainfall and flash flooding in Northwest Africa. ABSTRACT The winter of 2025–2026 in Morocco exhibited a rapid hydroclimatic transition from prolonged drought to widespread flooding, representing an ...
Afshin Amiri +2 more
wiley +1 more source
Physicochemical modeling of electron FLASH to identify the roles of oxygen, aqueous electrons and causal radical recombination effects underlying them. [PDF]
Phys Med BiolThomas WS +4 more
europepmc +1 more source
Rapid Communications in Mass Spectrometry, Volume 40, Issue 21, 15 November 2026.ABSTRACT Rationale The proteolytic behavior of chymosins during cheese ripening impacts cheese texture, flavor, and quality. Especially, the specific hydrolysis of αS1‐casein to αS1‐I‐casein is relevant for early cheese texture development, and this activity varies between chymosin variants.
Sebastiaan Dolman +7 more
wiley +1 more source