Results 241 to 250 of about 178,566 (304)

Polygenic risk scores for LATE-neuropathologic change: Implications for clinical utility. [PDF]

Alzheimers Dement
Pyun JM, Park YH, Shade LMP, Fardo DW, Kim S, Nho K, Alzheimer's Disease Neuroimaging Initiative.   +6 more
europepmc   +1 more source

Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng, Evan M. Cale, Amirabbas Maghsoudi, Matthew S. Sutton, Nancy S. Longo, Rebecca A. Gillespie, Lingshu Wang, Ivan Kosik, Sue Chong, Atsuhiro Yasuhara, Tatsiana Bylund, Arne Schön, Prabhanshu Tripathi, Yaroslav Tsybovsky, Haotian Lei, Nicholas C. Morano, Allison B. Lupatkin, Abraham J. Morton, Zabrina C. Lang, Jordan E. Becker, Isabella R. Frascilla, Myungjin Lee, Ning Li, Cuiping Liu, Ryan S. Roark, Chen‐Hsiang Shen, I‐Ting Teng, David J. Van Wazer, Danyi Wang, Lingyuan Wu, Goran Ahlsen, Mike Castro, Haijuan Du, Michael J. Ernandes, Tiansheng Li, Bob C. Lin, Mark K. Louder, Krisha McKee, Jonah S. Merriam, Sijy O'Dell, Li Ou, Sergei Pletnev, David Prikryl, Qi Qiu, Sarah Rubin, Mallika Sastry, Stephen D. Schmidt, Asif Shajahan, Andrea R. Shiakolas, Sanjay Srivatsan, Baoshan Zhang, Qiong Zhou, Mark Connors, Jason G. Gall, Yicheng Guo, Rick K. Huang, Yaoxing Huang, Richard A. Koup, Q. Paula Lei, John R. Mascola, Reda Rawi, Leonid Serebryannyy, Lawrence Shapiro, Zizhang Sheng, David D. Ho, Patrick C. Wilson, Jonathan W. Yewdell, Theodore C. Pierson, Masaru Kanekiyo, Nicole A. Doria‐Rose, Peter D. Kwong, Tongqing Zhou   +71 more
wiley   +1 more source

Caregiver positivity as a psychosocial modifier of lecanemab-related outcomes in Alzheimer's disease: A multicenter longitudinal study in China. [PDF]

Alzheimers Dement
Wu W, Liu H, Liang Y, Li H, Zhang J, Sun Z, Song Y, Fei M, Wu H, Jiang M, Fan S, Zhou C, Cao Y, Chen H, Liu S.   +14 more
europepmc   +1 more source

Optimized amyloid‐β PET centiloid and cognitive cutoffs predict progression from mild cognitive impairment to Alzheimer's dementia

Alzheimer's &Dementia, Volume 22, Issue 11, November 2026.
Abstract INTRODUCTION This study aimed to develop optimized prognostic cutoffs for amyloid‐β–positron emission tomography (Aβ‐PET) and Mini‐Mental State Examination (MMSE) that predict 3‐year progression from Clinical Dementia Rating Global (CDR‐Global) score 0.5 to 1.0 in mild cognitive impairment (MCI) participants and validate against cognitive ...
Rosita Shishegar, Vincent Doré, Pierrick Bourgeat, James D. Doecke, Rodrigo Cánovas, Simon M. Laws, Tenielle Porter, Michael Weiner, Colin L. Masters, Hamid R. Sohrabi, Jurgen Fripp, Paul Maruff, Victor L. Villemagne, Christopher C. Rowe, for the Alzheimer's Disease Neuroimaging Initiativethe Australian Imaging BiomarkersLifestyle flagship study of ageing   +14 more
wiley   +1 more source

Therapeutic Time Window of Disease-Modifying Therapy for Early Alzheimer's Disease in Japanese Individuals: Analysis Based on J-ADNI Study. [PDF]

Geriatr Gerontol Int
Nakashima S, Sato K, Niimi Y, Ihara R, Suzuki K, Iwata A, Satake W, Iwatsubo T, Japanese Alzheimer's Disease Neuroimaging Initiative.   +8 more
europepmc   +1 more source

Haplotype-resolved DiMeLo-seq maps centromeric chromatin in a complete diploid human genome. [PDF]

Cell Genom
Xu Y, Loucks H, Menendez J, Ryabov F, Lucas JK, Cechova M, Morina L, Xu E, Dubocanin D, Chittenden C, Asri M, Violich I, Ortiz C, Gardner JMV, Hillaker T, O'Rourke S, McNulty B, Potapova TA, Mitchell MW, Schwartz JP, Straight AF, Gerton JL, Timp W, Alexandrov IA, Altemose N, Miga KH.   +25 more
europepmc   +1 more source

Concentration-to-dose ratio as a predictor of lacosamide efficacy in Chinese children with epilepsy: a single-center retrospective cohort study. [PDF]

Front Pharmacol
Du Z, Wang Y, Nie G, Liu M, Li Y, Wang J.   +5 more
europepmc   +1 more source

Examining the Link Between Inflammation and Post-Operative Delirium in a Hip Fracture Repair Cohort of Older Adults. [PDF]

Delirium (Bielef)
Umoh ME, Wang N, Irwin KE, Sharma A, Leoutsakos J, Hamilton R, Lyketsos CG, Inouye SK, Marcantonio ER, Rosenberg PB, Neufeld KJ, Abadir P, Sieber F, Oh ES.   +13 more
europepmc   +1 more source

Cerebral amyloid associated with global cognition is differentially moderated by pulse pressure across education levels in The 90+ Study. [PDF]

Alzheimers Dement
Sapkota S, Fletcher E, Maillard P, Sajjadi SA, Corrada MM, DeCarli C.   +5 more
europepmc   +1 more source