Results 41 to 50 of about 149,367 (278)

Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective A 2‐min digital clock‐drawing test (DCTclock) captures more granular features of the clock‐drawing process than the pencil‐and‐paper clock‐drawing test, revealing more subtle deficits at the preclinical stage of Alzheimer's disease (AD). A previous cross‐sectional study demonstrated that worse DCTclock performance was associated with
Jessie Fanglu Fu, Talia Robinson, Marina Rodriguez Alonso, Adela Francis Malave, Roos J. Jutten, Michael J. Properzi, Brian C. Healy, Jackson C. Thompson, Grace Del Carmen Montenegro, Emma Thibault, Dana Penney, Randall Davis, Reisa A. Sperling, Kathryn V. Papp, Keith A. Johnson, Julie C. Price, Dorene M. Rentz   +16 more
wiley   +1 more source

Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones, Samuele Bonomi, Keith E. Stockerl‐Goldstein, Randall J. Bateman   +3 more
wiley   +1 more source

Coevolved Canonical Loops Conformations of Single-Domain Antibodies: A Tale of Three Pockets Playing Musical Chairs

Frontiers in Immunology, 2022
Single-domain antibodies (sdAbs) are a promising class of biotherapeutics with unique structural traits within their paratope region. The distribution of canonical conformations explored by their complementarity determining region (CDR) loops differs to ...
Francis Gaudreault, Christopher R. Corbeil, Enrico O. Purisima, Traian Sulea   +3 more
doaj   +1 more source

Experiment Simulation Configurations Used in DUNE CDR

, 2016
The LBNF/DUNE CDR describes the proposed physics program and experimental design at the conceptual design phase. Volume 2, entitled The Physics Program for DUNE at LBNF, outlines the scientific objectives and describes the physics studies that the DUNE ...
Alion, T., Back, J. J., Bashyal, A., Bass, M., Bishai, M., Cherdack, D., Diwan, M., Djurcic, Z., Evans, J., Fernandez-Martinez, E., Fields, L., Fleming, B., Gran, R., Guenette, R., Hewes, J., Hogan, M., Hylen, J., Junk, T., Kohn, S., LeBrun, P., Lundberg, B., Marchionni, A., Morris, C., Papadimitriou, V., Rameika, R., Rucinski, R., Soldner-Rembold, S., Sorel, M., Urheim, J., Viren, B., Whitehead, L., Wilson, R., Worcester, E., Zeller, G.   +33 more
core   +1 more source

$\gamma_{5}$ in FDH [PDF]

, 2017
We investigate the regularization-scheme dependent treatment of $\gamma_{5}$ in the framework of dimensional regularization, mainly focusing on the four-dimensional helicity scheme (FDH).
Gnendiger, C., Signer, A.
core   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

On the equivalence between Implicit Regularization and Constrained Differential Renormalization

, 2007
Constrained Differential Renormalization (CDR) and the constrained version of Implicit Regularization (IR) are two regularization independent techniques that do not rely on dimensional continuation of the space-time.
A.P. Baêta Scarpelli, A.P.B. Scarpelli, A.P.B. Scarpelli, A.P.B. Scarpelli, B. Hiller, C. Manuel, C.R. Pontes, D. Carneiro, D.M. Capper, D.Z. Freedman, D.Z. Freedman, D.Z. Freedman, D.Z. Freedman, E.W. Dias, F. del Aguila, F. del Aguila, F. del Aguila, F. del Aguila, G. Dunne, G. Hooft ’t, J. Comellas, J. Mas, J.E. Ottoni, J.I. Latorre, J.L. Acebal, J.S. Bell, L.A.M. Souza, M. Chaichian, M. Pérez Victoria, M. Sampaio, M. Sampaio, M.C. Nemes, Marcos Sampaio, N.N. Bogoliubov, O.A. Battistel, O.A. Battistel, P.E. Haagensen, P.E. Haagensen, P.E. Haagensen, R. Muñoz-Tapia, S. Adler, S.R. Gobira, V. Elias, V.A. Smirnov, V.A. Smirnov, W. Siegel   +45 more
core   +1 more source

The effects of donepezil in Alzheimer's disease - Results from a multinational trial [PDF]

, 1999
Donepezil has been shown to be well tolerated and to improve cognition and global function in patients with mild to moderately severe Alzheimer's disease (AD).
Burns, A., Friedhoff, L. T., Gauthier, S., Hecker, J., Möller, Hans-Jürgen, Petit, H., Rogers, S. L., Rossor, M.   +7 more
core   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Formation of upd(7)mat by trisomic rescue: SNP array typing provides new insights in chromosomal nondisjunction

Molecular Cytogenetics, 2017
Background Maternal uniparental disomy (UPD) of chromosome 7 (upd(7)mat) accounts for approximately 10% of patients with Silver-Russell syndrome (SRS).
Sandra Chantot-Bastaraud, Svea Stratmann, Frédéric Brioude, Matthias Begemann, Miriam Elbracht, Luitgard Graul-Neumann, Madeleine Harbison, Irène Netchine, Thomas Eggermann   +8 more
doaj   +1 more source