Results 81 to 90 of about 149,367 (278)

Gaussian Processes for Predictive QSAR Modeling of Chromatographic Processes

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chromatography is a key unit operation in the biopharmaceutical manufacturing process used for protein purification and polishing. Design and optimization of these processes are resource‐intensive resulting from the complex combinatorial design space.
Harini Narayanan, Douglas Nolan, Lijuan Li, Edward King, Andrew Fiordalis, David Benjamin Nickel, George Parks, J. Christopher Love   +7 more
wiley   +1 more source

Navigating the Net Zero Transition: Towards Improved Effectiveness of Corporate Decarbonization Strategies

Business Strategy and the Environment, EarlyView.
ABSTRACT With net zero CO2 emissions as the benchmark for mitigating the worst impacts of climate change by mid‐century, businesses are urged to deploy robust reduction measures. However, in light of increasing emissions globally, the effectiveness of current corporate decarbonization strategies remains unclear.
Linda Schenzle, Timo Busch
wiley   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy

Clinical Epigenetics, 2013
5-Aza-2′-deoxycytidine (5-AZA-CdR, decitabine), an epigenetic drug that inhibits DNA methylation, is currently used to treat myelodysplastic syndrome (MDS), and is under investigation for treating acute myeloid leukemia (AML) and other malignancies.
Karahoca Metin, Momparler Richard L
doaj   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Optimization of low sintering temperature for colossal permittivity and humidity resistance in TiO2 based ceramics

Scientific Reports
This study investigates the colossal permittivity (CP) and humidity resistance of (Sn1/2Nb1/2)0.025Ti0.975O2 ceramics. Increasing the sintering temperature enhanced both density and grain growth, with the fine–grained structure proving essential for ...
Yasumin Mingmuang, Narong Chanlek, Masaki Takesada, Ekaphan Swatsitang, Prasit Thongbai   +4 more
doaj   +1 more source

Quantifying the impact of a computer‐aided diagnostic score on the clinical diagnosis of functional seizures

Epilepsia, EarlyView.
Abstract Objective The diagnosis of functional/dissociative seizures (FDS) without ictal video‐electroencephalography is challenging. The Functional/Dissociative Seizures Likelihood Score (FSLS) is a machine learning‐based diagnostic score that aims to help clinicians identify FDS.
Wesley T. Kerr, Katherine N. McFarlane, Corinne H. Allas, Samuel W. Terman, Markus Reuber, Sung Hyun Seo, Payge Barnard, Adriana Y. Koek, Amir H. Karimi, Siddhika S. Sreenivasan, Jena S. Grauer, Di Sun, Meagan Watson, Elissa H. Patterson, James Castellano, Anto I. Bagić, L. Brian Hickman, Kenneth H. Kutschman, Laurence Knowles, Alistair Wardrope, Piyush Ostwal, Bridget K. MacDonald, Melissa Berry, Lomalan Reddy, Najda Robinson‐Mayer, Nicholas J. Beimer, Rachna Reddy, Sarah K. Yaghoubi, Laura A. Kirkpatrick, Danielle R. Carns, Alex J. Israel, Jamie D. Feusner, Zongqi Xia, Yanshan Wang, Laura A. Strom, Page B. Pennell, John M. Stern, Lubomir Hadjiiski, William C. Stacey   +38 more
wiley   +1 more source

The Evolution of Adenoviral Vectors through Genetic and Chemical Surface Modifications

Viruses, 2014
A long time has passed since the first clinical trial with adenoviral (Ad) vectors. Despite being very promising, Ad vectors soon revealed their limitations in human clinical trials.
Cristian Capasso, Mariangela Garofalo, Mari Hirvinen, Vincenzo Cerullo   +3 more
doaj   +1 more source

Public Perceptions and Engagement for Carbon Capture, Utilization, and Storage: Literature Review With a Case Study of Utah, USA

Greenhouse Gases: Science and Technology, EarlyView.
ABSTRACT Carbon dioxide capture, utilization, and storage (CCUS) is a potential key to mitigating anthropogenic CO2 emissions and associated impacts on global climate change. Successful CCUS deployment hinges on both technological advancements and public support.
Ting Xiao, Erin Middleton, Omar Bakelli, Sophia Cheng, Danyang Zhu, Lei Xu, Brian McPherson   +6 more
wiley   +1 more source

Tuning enhanced dielectric properties of (Sc3+–Ta5+) substituted TiO2 via insulating surface layers

Scientific Reports
In this study, we achieved significantly enhanced giant dielectric properties (EG-DPs) in Sc3+–Ta5+ co-doped rutile-TiO2 (STTO) ceramics with a low loss tangent (tanδ ≈ 0.05) and high dielectric permittivity (ε′ ≈ 2.4 × 104 at 1 kHz).
Wattana Tuichai, Pornjuk Srepusharawoot, Supamas Danwittayakul, Prasit Thongbai   +3 more
doaj   +1 more source