Results 81 to 90 of about 6,828 (261)

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Prediksi Curah Hujan Menggunakan Data Hujan Satelit CHIRPS dan PERSIANN-CDR di DAS Bedadung Kabupaten Jember

, 2022
Angel Novita Tri lara Atica, Gusfan Halik, Saifurridzal   +2 more
openalex   +2 more sources

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Short IQCODE as a screening tool for MCI and dementia: preliminary results

Dementia & Neuropsychologia
Reaching a diagnosis may be difficult in the initial stages of dementia, especially in low educated individuals, when informant reports may be useful. Objectives: To compare the sensitivity and specificity of the IQCODE against cognitive tests applied in
Tíbor Rilho Perroco, Antonio Eduardo Damin, Norberto A. Frota, Mari-Nilva M. Silva, Viviane Rossi, Ricardo Nitrini, Cássio M.C. Bottino   +6 more
doaj   +1 more source

DeepANIS: Predicting antibody paratope from concatenated CDR sequences by integrating bidirectional long-short-term memory and transformer neural networks

, 2021
Pan Zhang, Shuangjia Zheng, Jianwen Chen, Yaoqi Zhou, Yuedong Yang   +4 more
openalex   +2 more sources

Graded extent of hippocampal resection is related to neuropsychological outcomes in temporal lobe epilepsy surgery

Epilepsia, EarlyView.
Abstract Objective Surgical resection for epilepsy seeks to maximize seizure freedom while minimizing new neurocognitive impairments. Tailored resections guided by anatomoelectroclinical (AEC) hypotheses offer the possibility of sparing parts of the hippocampus.
Eliza M. Reedy, Emma Robinson, Thandar Aung, Catherine Liégeois‐Chauvel, Danielle R. Carns, Natalie Sherry, Luke C. Henry, Bradford Z. Mahon, Arka N. Mallela, Jorge A. Gonzalez‐Martinez   +9 more
wiley   +1 more source

Assessing the Impactof CDR Deamidation and Isomerizationon mAb Target Binding Using Affinity-Resolved 2D-SEC-SCX-MS Analysis [PDF]

Yuetian Yan (1319676), Shuli Tang (5738810), Shunhai Wang (1940665), Ning Li (45258)   +3 more
openalex   +2 more sources

Government affiliation and innovation in emerging market firms: The role of international diversification

Global Strategy Journal, EarlyView.
Abstract Research Summary This study examines how international diversification interacts with government affiliation to shape innovation outcomes in emerging market firms. We reconceptualize government affiliation as a resource‐structuring mechanism that varies across hierarchical levels and influences the coherence of firms' dominant logics of ...
Danielle R. Combs, Fiona Kun Yao, Chunlin Liu, Ting Xiao   +3 more
wiley   +1 more source

Disrupted Brain Structure and Function in Alzheimer's Disease Patients With Behavioral and Psychological Symptoms

iNew Medicine, EarlyView.
ABSTRACT Behavioral and psychological symptoms of dementia (BPSD) are highly prevalent in Alzheimer's disease (AD), but the underlying mechanisms are unclear. This study aims to elucidate the neuropathological mechanisms underlying BPSD by investigating gray matter volume (GMV) and brain connectivity in AD patients with and without BPSD.
Xuerui Pang, Linbo Xie, Mengdan Chen, Yi Ji, Yibing Yan, Shanshan Zhou, Panpan Hu, Xingqi Wu, Kai Wang   +8 more
wiley   +1 more source