Results 81 to 90 of about 178,566 (304)

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Carbon Dioxide Removal (CDR)

Key points • Carbon Dioxide Removal (CDR) is an umbrella term for techniques that capture carbon dioxide from the air and store it durably, as a result of human activity.
Smith, Steve, Hope, George, Bird, Jennifer, Westbury, Philippa   +3 more
core   +1 more source

Deep Learning for AD Risk Screening and Progression Prediction

Advanced Science, EarlyView.
A pretrained MRI‐based deep learning model generalizes from Western cohorts to an independent Chinese cohort, detects Alzheimer's disease with high sensitivity, and identifies elevated AD risk years before diagnosis. Its risk scores align with cognition and plasma biomarkers, and individualized brain risk maps uncover clinically distinct subtypes ...
Bin Lu, Yan‐Rong Chen, Rui‐Xian Li, Ming‐Kai Zhang, Shao‐Zhen Yan, Guan‐Qun Chen, Jing‐Hua Wang, Wen‐Hui Chai, Francisco Xavier Castellanos, Paul M. Thompson, Jie Lu, Ying Han, Chao‐Gan Yan   +12 more
wiley   +1 more source

Optimization of low sintering temperature for colossal permittivity and humidity resistance in TiO2 based ceramics

Scientific Reports
This study investigates the colossal permittivity (CP) and humidity resistance of (Sn1/2Nb1/2)0.025Ti0.975O2 ceramics. Increasing the sintering temperature enhanced both density and grain growth, with the fine–grained structure proving essential for ...
Yasumin Mingmuang, Narong Chanlek, Masaki Takesada, Ekaphan Swatsitang, Prasit Thongbai   +4 more
doaj   +1 more source

Epigenetic Activation of ANGPTL4 Drives EBV‐Negative Gastric Cancer via Neutrophil Recruitment and NET Release via Stabilizing ANXA5

Advanced Science, EarlyView.
ANGPTL4 exhibits distinct promoter methylation patterns and expression profiles in EBV‐positive versus EBV‐negative gastric cancer. Secreted C‐terminal ANGPTL4 (cANGPTL4) acts as the dominant functional isoform driving GC proliferation, EMT, and neutrophil infiltration. cANGPTL4 promotes neutrophil recruitment via NF‐κB/CXCL8 axis.
Dandan Li, Xinqi Li, Xiangyin Luo, Jiayi Wang, Yiwei Zha, Zeng Zhou, Yanyan Chen, Qi Wang, Lingyun Xia, Weidong Leng, Shanshan Qin   +10 more
wiley   +1 more source

The Evolution of Adenoviral Vectors through Genetic and Chemical Surface Modifications

Viruses, 2014
A long time has passed since the first clinical trial with adenoviral (Ad) vectors. Despite being very promising, Ad vectors soon revealed their limitations in human clinical trials.
Cristian Capasso, Mariangela Garofalo, Mari Hirvinen, Vincenzo Cerullo   +3 more
doaj   +1 more source

Tuning enhanced dielectric properties of (Sc3+–Ta5+) substituted TiO2 via insulating surface layers

Scientific Reports
In this study, we achieved significantly enhanced giant dielectric properties (EG-DPs) in Sc3+–Ta5+ co-doped rutile-TiO2 (STTO) ceramics with a low loss tangent (tanδ ≈ 0.05) and high dielectric permittivity (ε′ ≈ 2.4 × 104 at 1 kHz).
Wattana Tuichai, Pornjuk Srepusharawoot, Supamas Danwittayakul, Prasit Thongbai   +3 more
doaj   +1 more source

Study on Biocompatibility of AuNPs and Theoretical Design of a Multi-CDR-Functional Nanobody

, 2019
The investigation on proteinlike specific functions of nanoparticles (NPs) has been a huge challenge. Here, the biocompatibility of Au nanoparticles (AuNPs) to antigens hen egg white lysozyme and epidermal growth factor receptor was studied first by ...
Li Ting Song (7296710), Hong Lin Zhai (7296716), Ya Jie Meng (7296713), Rui Rui Liu (7296707), Min Zhu (168912)   +4 more
core   +1 more source

AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective

Advanced Intelligent Discovery, EarlyView.
The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley   +1 more source

Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy

Clinical Epigenetics, 2013
5-Aza-2′-deoxycytidine (5-AZA-CdR, decitabine), an epigenetic drug that inhibits DNA methylation, is currently used to treat myelodysplastic syndrome (MDS), and is under investigation for treating acute myeloid leukemia (AML) and other malignancies.
Karahoca Metin, Momparler Richard L
doaj   +1 more source