Results 131 to 140 of about 473,209 (278)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Economic evaluations of antiobesity medications: A systematic literature review

British Journal of Clinical Pharmacology, EarlyView.
The global prevalence of obesity is rising rapidly. With several antiobesity medications approved and many more in development, understanding their economic value is increasingly important. This study reviews full economic evaluations of approved antiobesity medications to assess cost‐effectiveness and inform reimbursement and access decisions.
Martina Jurković, Almir Fajkić, Andrea Katrin Faour, Mirna Momčilović, Petra Turčić, Andrej Belančić   +5 more
wiley   +1 more source

Immobilization of Alginate Microbeads With Whole‐Cells Expressing Nitrilase for Continuous Nicotinic Acid Production in Chip Millireactor

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The biocatalytic production of nicotinic acid using nitrilases has emerged as a promising alternative to conventional chemical synthesis, offering improved selectivity and environmental sustainability. In this study, we developed a continuous‐flow millireactor system employing Escherichia coli cells expressing a nitrilase from Paraburkholderia
Jonathan Bassut, Emina Mehić, Luana Cuvillier, Carine Vergne‐Vaxelaire, Jean‐Louis Petit, Maïté Michaud, Zoé Anxionnaz‐Minvielle, Anne Zaparucha, Guillaume Nonglaton   +8 more
wiley   +1 more source

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

From Managerial Awareness to Behavior in the Circular Economy: The Role of Personality Traits and Organizational Support

Business Strategy and the Environment, EarlyView.
ABSTRACT As businesses are increasingly integrating circular economy (CE) principles to promote concrete sustainability actions, understanding which managerial aspects may align with this change becomes paramount. Employing a conceptual framework based on Cognitive‐Affective Personality System (CAPS) and Organizational Support theories, this study ...
Fiorenza Meucci, Flavio Spagnuolo, Annamaria Zampella, Marco Maffei   +3 more
wiley   +1 more source

Evaluation of VISIA-Derived Erythema Metrics Against Blinded Clinician Assessment After Intense Pulsed Light Therapy in Erythematotelangiectatic Rosacea: A Real-World Cohort Study. [PDF]

Clin Cosmet Investig Dermatol
Fan B, Meng X, Yu R.
europepmc   +1 more source

Does the CEO's Attention Affect How Well the Firm Performs Environmentally?

Business Strategy and the Environment, EarlyView.
ABSTRACT This study explores whether CEOs' environmental attention (CEA) enhances firms' environmental performance. Drawing on attention‐based and upper echelons theories, which emphasize that executives' cognitive focus shapes organizational outcomes, we argue that CEOs who devote greater attention to environmental issues are more likely to integrate ...
Salah Aldain Abdullah Alshorman, Mohammad Abweny, Rizwan Ahmed   +2 more
wiley   +1 more source

Cannabinoid modulation of central amygdala population dynamics during threat investigation. [PDF]

Nat Commun
Yasmin F, Naskar S, Zaidi D, Kandil I, Kwon M, Rosas-Vidal LE, Patel S.   +6 more
europepmc   +1 more source

Water as a Strategic Design Variable for Climate‐Resilient Urban Farming: Reconfiguring Sustainable Business Models Through the Water‐Enabled Resource Architecture Framework

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examines how water sourcing and management can be embedded within urban farming business models to enhance environmental sustainability, climate resilience, and economic viability. It introduces the water‐enabled resource architecture (WERA) framework, which conceptualizes water as a strategic design variable capable of reshaping ...
Nicolò Gianmauro Totaro, Gianvito Nesca, Federica Stella Blasi, Marta Sozzo, Giovanni Schiuma   +4 more
wiley   +1 more source

Modern approaches and future prospects in lettuce breeding for controlled environment agriculture. [PDF]

Front Plant Sci
Poudel A, Bhusal A, Bhattarai K.
europepmc   +1 more source