Results 191 to 200 of about 89,671 (248)
VIEW, EarlyView.Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley +1 more source
VIEW, EarlyView.(A) Overview of the study population and schematic illustration showing tumor‐derived apoptotic and metabolic biomarkers, Apo10 and TKTL1, being phagocytosed by circulating monocytes and subsequently detected in peripheral blood. (B) Illustration of the epitope detection in monocytes (EDIM) strategy, using a flow‐cytometric gating approach based on ...
Zhiying Mao +8 more
wiley +1 more source
VIEW, EarlyView.Pancreatic ductal adenocarcinoma exhibits marked angiogenic and immune heterogeneity. We identified 28 angiogenesis‐associated immune genes and developed a seven‐gene AIGScore model comprising FGF2, ADGRB3, MMP2, TYMP, VASH1, VEGFD, and ITGAV. A high AIGScore was associated with poor survival, an immunosuppressive tumor microenvironment, and reduced ...
Qing Chang +4 more
wiley +1 more source
VIEW, EarlyView.Electrochemical aptasensors are emerging as powerful platforms for precision diagnostics and environmental monitoring, owing to their high selectivity, programmability and compatibility with miniaturised systems. However, their broader application is constrained by limited signal intensity and challenges in reliable multiplexed detection.
Azadeh Abdi +5 more
wiley +1 more source
Deterministic segmentation of grains in dense Laue microdiffraction datasets
Journal of Applied Crystallography, EarlyView.This work introduces a deterministic methodology for segmenting individual grain contributions from complex high‐density Laue microdiffraction datasets by leveraging spatial correlations and clustering of peak appearance maps.Although Laue microdiffraction is an essential non‐destructive technique for probing crystallographic orientation and strain at ...
Sergio Bongiorno +3 more
wiley +1 more source
Separating the effects of temperature and absorbed X‐ray dose on unit‐cell volume
Acta Crystallographica Section D, EarlyView.The nature of the expansion of the crystal unit‐cell volume with absorbed dose and with temperature was examined for three different proteins.The behaviour of the unit‐cell volume of crystals of the iron‐storage molecule ferritin, both in the apo and the holo form, and of influenza A virus subtype N9 neuraminidase at 100 K and over a controlled cryo ...
Robert J. Southworth-Davies +5 more
wiley +1 more source
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Objective To determine whether vaginal oestrogen therapy improves outcomes after prolapse surgery in postmenopausal women. Design Double‐blind, randomised, placebo‐controlled trial with 12 month follow‐up. Setting Multicentre, 22 hospitals in the Netherlands.
Eva V. Vodegel +25 more
wiley +1 more source
Benchmarked Colorectal Cancer Outcomes in a Metropolitan Hospital: A 5‐Year Review
Asia-Pacific Journal of Clinical Oncology, EarlyView.In metastatic disease, patients with lung‐only metastasis had the best 5‐year survival at 46.0% and curative‐intent approaches can dramatically improve survival. ABSTRACT Introduction Colorectal cancer (CRC) remains a major contributor to cancer‐related mortality worldwide, with survival influenced by many prognostic factors.
Jialin Du +3 more
wiley +1 more source
Award-Winning Innovative Aircraft Design Projects at Politecnico di Milano
, 2017 TRAINELLI, LORENZO +1 more
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