Results 1 to 10 of about 66,104,498 (114)

Clinical and Genetic Characteristics of Korean Patients Diagnosed with Chronic Enteropathy Associated with SLCO2A1 Gene: A KASID Multicenter Study [PDF]

Gut and Liver, 2022
Background/Aims: Chronic enteropathy associated with SLCO2A1 gene (CEAS), an inherited disease characterized by nonspecific intestinal ulcers, has emerged in the Japanese population via loss-of-function mutations in the SLCO2A1 gene.
Hee Seung Hong, Jiwon Baek, Jae Chul Park, Ho-Su Lee, Dohoon Park, A-Ran Yoon, Soo Jung Park, Sung Noh Hong, Seong-Joon Koh, Chang Kyun Lee, Bo-In Lee, Sung Wook Hwang, Sang Hyoung Park, Seung-Jae Myung, Suk-Kyun Yang, Kyuyoung Song, Byong Duk Ye, on behalf of the IBD Research Group of the Korean Association for the Study of Intestinal Diseases   +17 more
doaj   +5 more sources

Characteristics of chronic enteropathy associated with SLCO2A1 gene (CEAS) in children, a unique type of monogenic very early-onset inflammatory bowel disease [PDF]

BMC Pediatrics
Background  Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a unique type of inflammatory bowel disease. CEAS is monogenic disease and is thought to develop from childhood, but studies on pediatric CEAS are scarce.
Jin Gyu Lim, Jae Sung Ko, Jung Min Ko, Hyun Young Kim, Man Jin Kim, Moon Woo Seong, Young Hun Choi, Gyeong Hoon Kang, Jaemoon Koh, Jin Soo Moon   +9 more
doaj   +3 more sources

Integrative Proteomics and Phosphoproteomics Profiling of Chronic Enteropathy Associated with SLCO2A1 Gene Reveals Mucosal Barrier Impairment and Focal Adhesion Pathway Alterations [PDF]

Biomedicines
Background: Chronic enteropathy associated with the SLCO2A1 gene (CEAS) is a rare disease characterized by multiple small intestinal ulcers whose pathogenesis remains poorly understood.
Zhixin Xie, Taotao Han, Dong Wu, Jingnan Li, Aiming Yang, Yue Li, Qiang Wang   +6 more
doaj   +3 more sources

A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy.

PLoS ONE, 2020
Chronic enteropathy associated with SLCO2A1 gene (CEAS) is caused by loss-of-function mutations in SLCO2A1, which encodes a prostaglandin (PG) transporter.
Keisuke Jimbo, Toshiaki Okuno, Ryuichi Ohgaki, Kou Nishikubo, Yuri Kitamura, Yumiko Sakurai, Lili Quan, Hiromichi Shoji, Yoshikatsu Kanai, Toshiaki Shimizu, Takehiko Yokomizo   +10 more
doaj   +3 more sources

Structure and transport mechanism of the human prostaglandin transporter SLCO2A1 [PDF]

Nature Communications
SLCO2A1 is a member of the organic anion transporting polypeptide (OATP) family, which preferentially transports prostaglandins (PGs) into cells and plays a vital role in regulating PGs inactivation and distribution.
Zhanyi Xia, Guangyuan Lu, Di Wu, Jun Zhao, Bowen Zhang, Haoran Xu, Yingying Du, Daohua Jiang   +7 more
doaj   +3 more sources

A pediatric patient with chronic enteropathy associated with SLCO2A1 who underwent multimodal treatment including several surgeries: a case report [PDF]

Frontiers in Surgery
IntroductionChronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare protein-losing enteropathy primarily recognized in Asia. Its uncommon nature and limited research usually complicate diagnosis and treatment. This review examines the course of
Yoojin Jung, Jaehee Chung, Inhyuk Yoo
doaj   +4 more sources

Estimated Prevalence of Cronkhite-Canada Syndrome, Chronic Enteropathy Associated With SLCO2A1 Gene, and Intestinal Behçet’s Disease in Japan in 2017: A Nationwide Survey [PDF]

Journal of Epidemiology, 2021
Background: Cronkhite-Canada syndrome (CCS), chronic enteropathy associated with SLCO2A1 gene (CEAS), and intestinal Behçet’s disease (BD) are classified as intractable intestinal disorders in Japan.
Mari S. Oba, Yoshitaka Murakami, Yuji Nishiwaki, Keiko Asakura, Satoko Ohfuji, Wakaba Fukushima, Yosikazu Nakamura, Yasuo Suzuki   +7 more
doaj   +2 more sources

Chronic Enteropathy Associated with <italic>SLCO2A1</italic> Gene [PDF]

Inflammatory Intestinal Diseases
Background: Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare hereditary disorder characterized by multiple small intestinal ulcers, chronic anemia, and hypoproteinemia. Initially reported by Okabe et al.
Junji Umeno, Motohiro Esaki, Keiichi Uchida, Takayuki Matsumoto   +3 more
doaj   +2 more sources

Clinical and genetic characteristics of Chinese patients diagnosed with chronic enteropathy associated with SLCO2A1 gene [PDF]

Orphanet Journal of Rare Diseases
Background and aims Chronic enteropathy associated with SLCO2A1 gene is a rare intestinal disease caused by loss-of-function SLCO2A1 mutations, with clinical and genetic characteristics remaining largely unknown, especially in Chinese patients.
Qing Shang, Yimin Dai, Jingyi Huang, Wei Liu, Weixun Zhou, Yaping Liu, Hong Yang, Qiang Wang, Yue Li   +8 more
doaj   +2 more sources

Immunohistochemical differentiation between chronic enteropathy associated with gene and other inflammatory bowel diseases [PDF]

Intestinal Research, 2018
Background/AimsWe recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) as causative variants of chronic enteropathy associated with SLCO2A1 (CEAS).
Satoko Yamaguchi, Shunichi Yanai, Shotaro Nakamura, Keisuke Kawasaki, Makoto Eizuka, Noriyuki Uesugi, Tamotsu Sugai, Junji Umeno, Motohiro Esaki, Takayuki Matsumoto   +9 more
doaj   +2 more sources