Results 11 to 20 of about 509 (131)

Slco2a1 deficiency exacerbates experimental colitis via inflammasome activation in macrophages: a possible mechanism of chronic enteropathy associated with SLCO2A1 gene. [PDF]

Sci Rep, 2020
Loss-of-function mutations in the solute carrier organic anion transporter family, member 2a1 gene (SLCO2A1), which encodes a prostaglandin (PG) transporter, have been identified as causes of chronic nonspecific multiple ulcers in the small intestine ...
Nakata R, Nakamura Y, Hosomi S, Okuda H, Nishida Y, Sugita N, Itani S, Nadatani Y, Otani K, Tanaka F, Kamata N, Taira K, Nagami Y, Tanigawa T, Watanabe T, Yamagami H, Nakanishi T, Fujiwara Y.   +17 more
europepmc   +7 more sources

Distinction between Chronic Enteropathy Associated with the SLCO2A1 Gene and Crohn’s Disease

Gut and Liver, 2019
Background/Aims We recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) as causative variants of chronic nonspecific multiple ulcers of the small intestine (chronic enteropathy ...
Shunichi Yanai, Satoko Yamaguchi, Shotaro Nakamura, Keisuke Kawasaki, Yosuke Toya, Noriyuki Yamada, Makoto Eizuka, Noriyuki Uesugi, Junji Umeno, Motohiro Esaki, Eiko Okimoto, Shunji Ishihara, Tamotsu Sugai, Takayuki Matsumoto   +13 more
doaj   +7 more sources

P868 Clinical features of chronic enteropathy associated with SLCO2A1 gene [PDF]

Journal of Crohn's and Colitis, 2023
Chronic enteropathy associated with the SLCO2A1 gene (CEAS) is a hereditary disease caused by mutations of the SLCO2A1 gene which encodes a prostaglandin transporter.
J. Umeno, Y. Fuyuno, T. Torisu, Y. Matsuno, M. Esaki, S. Yanai, N. Ohmiya, T. Hisamatsu, K. Watanabe, N. Hosoe, H. Ogata, F. Hirai, T. Hisabe, T. Matsui, T. Kitazono, T. Matsumoto   +15 more
exaly   +4 more sources

Structure and transport mechanism of the human prostaglandin transporter SLCO2A1 [PDF]

Nature Communications
SLCO2A1 is a member of the organic anion transporting polypeptide (OATP) family, which preferentially transports prostaglandins (PGs) into cells and plays a vital role in regulating PGs inactivation and distribution.
Zhanyi Xia, Guangyuan Lu, Di Wu, Jun Zhao, Bowen Zhang, Haoran Xu, Yingying Du, Daohua Jiang   +7 more
doaj   +4 more sources

Eosinophilic enteritis requiring differentiation from chronic enteropathy associated with SLCO2A1 gene: A case report. [PDF]

World J Gastroenterol, 2023
BACKGROUND Eosinophilic gastrointestinal disease (EGID) is a disorder characterized by infiltration of eosinophils causing mucosal damage and dysfunction of the gastrointestinal tract.
Kimura K, Jimbo K, Arai N, Sato M, Suzuki M, Kudo T, Yano T, Shimizu T.   +7 more
europepmc   +4 more sources

Successful azathioprine treatment in an adolescent with chronic enteropathy associated with SLCO2A1 gene: A case report. [PDF]

Medicine (Baltimore), 2018
Introduction: Chronic nonspecific multiple ulcers of the small intestine (CNSU), an entity with female preponderance and manifestations including anemia and hypoproteinemia reflecting persistent gastrointestinal bleeding and intestinal protein loss, has ...
Eda K, Mizuochi T, Takaki Y, Ushijima K, Umeno J, Yamashita Y.   +5 more
europepmc   +4 more sources

P215 Clinical features of chronic enteropathy associated with SLCO2A1 gene (CEAS) [PDF]

Journal of Crohn's and Colitis, 2017
Motohiro Esaki, Atsushi Hirano
exaly   +4 more sources

P752 A nationwide survey of chronic enteropathy associated with SLCO2A1 gene in Japan [PDF]

Journal of Crohn's and Colitis, 2020
Chronic enteropathy associated with SLCO2A1 gene (CEAS) is an autosomal recessive disease caused by mutations in the SLCO2A1 gene which encodes a prostaglandin transporter.
J. Umeno, Y. Fuyuno, T. Torisu, A. Hirano, M. Esaki, S. Yanai, N. Ohmiya, T. Hisamatsu, Kenji Watanabe, Naoki Hosoe, H. Ogata, Fumihito Hirai, T. Hisabe, T. Matsui, T. Yao, T. Kitazono, T. Matsumoto   +16 more
semanticscholar   +3 more sources

A pediatric patient with chronic enteropathy associated with SLCO2A1 who underwent multimodal treatment including several surgeries: a case report [PDF]

Frontiers in Surgery
IntroductionChronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare protein-losing enteropathy primarily recognized in Asia. Its uncommon nature and limited research usually complicate diagnosis and treatment. This review examines the course of
Yoojin Jung, Jaehee Chung, Inhyuk Yoo
doaj   +3 more sources

Chronic Enteropathy Associated With SLCO2A1 Gene [CEAS]-Characterisation of an Enteric Disorder to be Considered in the Differential Diagnosis of Crohn's Disease. [PDF]

Journal of Crohn's and Colitis, 2017
Small intestinal ulcers include mucosal damage caused by drugs, particularly nonsteroidal anti-inflammatory drugs [NSAIDs], infectious diseases, and idiopathic inflammatory bowel disease. Previously, a group of Japanese investigators reported an unusual and uncommon type of enteritis and referred to the condition as chronic nonspecific multiple ulcers ...
Naoki Hosoe, N. Ohmiya, Fumihito Hirai, J. Umeno, M. Esaki, H. Yamagami, K. Onodera, S. Bamba, H. Imaeda, S. Yanai, T. Hisamatsu, H. Ogata, T. Matsumoto   +12 more
semanticscholar   +3 more sources