Regulation of organic anion transporters: Role in physiology, pathophysiology, and drug elimination. [PDF]
Pharmacol Ther, 2021 The members of the organic anion transporter (OAT) family are mainly expressed in kidney, liver, placenta, intestine, and brain. These transporters play important roles in the disposition of clinical drugs, pesticides, signaling molecules, heavy metal ...
Zhang J, Wang H, Fan Y, Yu Z, You G.
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SLC17: a functionally diverse family of organic anion transporters. [PDF]
Mol Aspects Med, 2013 Molecular studies have determined that the SLC17 transporters, a family of nine proteins initially implicated in phosphate transport, mediate the transport of organic anions. While their role in phosphate transport remains uncertain, it is now clear that
Reimer RJ.
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Post-translational regulation of the major drug transporters in the families of organic anion transporters and organic anion-transporting polypeptides. [PDF]
J Biol Chem, 2020 The organic anion transporters (OATs) and organic anion–transporting polypeptides (OATPs) belong to the solute carrier (SLC) transporter superfamily and play important roles in handling various endogenous and exogenous compounds of anionic charge.
Lee W, Ha JM, Sugiyama Y.
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Protective effect of cilastatin against diclofenac-induced nephrotoxicity through interaction with diclofenac acyl glucuronide via organic anion transporters. [PDF]
Br J Pharmacol, 2020 Diclofenac is a widely used nonsteroidal anti‐inflammatory drug. However, adverse effects in the kidney limit its clinical application. The present study was aimed to evaluate the potential effect of cilastatin on diclofenac‐induced acute kidney injury ...
Huo X +8 more
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Overview of organic anion transporters and organic anion transporter polypeptides and their roles in the liver. [PDF]
World J Clin Cases, 2019 Organic anion transporters (OATs) and organic anion transporter polypeptides (OATPs) are classified within two SLC superfamilies, namely, the SLC22A superfamily and the SLCO superfamily (formerly the SLC21A family), respectively.
Li TT, An JX, Xu JY, Tuo BG.
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Involvement of Organic Anion Transporters in the Pharmacokinetics and Drug Interaction of Rosmarinic Acid [PDF]
Pharmaceutics, 2021 We investigated the involvement of drug transporters in the pharmacokinetics of rosmarinic acid in rats as well as the transporter-mediated drug interaction potential of rosmarinic acid in HEK293 cells overexpressing clinically important solute carrier ...
Yun Ju Kang +5 more
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Structures suggest a mechanism for energy coupling by a family of organic anion transporters. [PDF]
PLoS Biol, 2019 Members of the solute carrier 17 (SLC17) family use divergent mechanisms to concentrate organic anions. Membrane potential drives uptake of the principal excitatory neurotransmitter glutamate into synaptic vesicles, whereas closely related proteins use ...
Leano JB +9 more
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Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes. [PDF]
Sci Rep, 2017 In vitro data indicates that the kidney proximal tubule (PT) transporters of uremic toxins and solutes (e.g., indoxyl sulfate, p-cresol sulfate, kynurenine, creatinine, urate) include two “drug” transporters of the organic anion transporter (OAT) family:
Wu W, Bush KT, Nigam SK.
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Recent Advances on the Regulations of Organic Anion Transporters [PDF]
PharmaceuticsThe organic anion transporter (OAT) family of over 10 members within the solute carrier (SLC) superfamily of membrane proteins plays critical roles in facilitating the flux of negatively charged molecules in and out of cell membranes.
Zhou Yu, Guofeng You
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(−)-Epigallocatechin-3-gallate Inhibits Human and Rat Renal Organic Anion Transporters [PDF]
ACS Omega, 2021 Tatsuya Kawasaki +3 more
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