Post-translational regulation of the major drug transporters in the families of organic anion transporters and organic anion–transporting polypeptides [PDF]
Journal of Biological Chemistry, 2020 The organic anion transporters (OATs) and organic anion-transporting polypeptides (OATPs) belong to the solute carrier (SLC) transporter superfamily and play important roles in handling various endogenous and exogenous compounds of anionic charge. The OATs and OATPs are often implicated in drug therapy by impacting the pharmacokinetics of clinically ...
Wooin Lee, Yuichi Sugiyama
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Recent Advances on the Regulations of Organic Anion Transporters [PDF]
PharmaceuticsThe organic anion transporter (OAT) family of over 10 members within the solute carrier (SLC) superfamily of membrane proteins plays critical roles in facilitating the flux of negatively charged molecules in and out of cell membranes.
Zhou Yu, Guofeng You
doaj +4 more sources
Renal Organic Anion Transporters 1 and 3 In Vitro: Gone but Not Forgotten [PDF]
International Journal of Molecular Sciences, 2023 Organic anion transporters 1 and 3 (OAT1 and OAT3) play a crucial role in kidney function by regulating the secretion of multiple renally cleared small molecules and toxic metabolic by-products.
Pedro Caetano-Pinto, Simone H Stahl
exaly +4 more sources
Involvement of Organic Anion Transporters in the Pharmacokinetics and Drug Interaction of Rosmarinic Acid [PDF]
Pharmaceutics, 2021 We investigated the involvement of drug transporters in the pharmacokinetics of rosmarinic acid in rats as well as the transporter-mediated drug interaction potential of rosmarinic acid in HEK293 cells overexpressing clinically important solute carrier ...
Yun Ju Kang +5 more
doaj +2 more sources
Overview of organic anion transporters and organic anion transporter polypeptides and their roles in the liver. [PDF]
World J Clin Cases, 2019 Organic anion transporters (OATs) and organic anion transporter polypeptides (OATPs) are classified within two SLC superfamilies, namely, the SLC22A superfamily and the SLCO superfamily (formerly the SLC21A family), respectively. They are expressed in many tissues, such as the liver and kidney, and mediate the absorption and excretion of many ...
Li TT, An JX, Xu JY, Tuo BG.
europepmc +3 more sources
Interactions of Organic Anion Transporters and Organic Cation Transporters With Mycotoxins
Journal of Pharmacological Sciences, 2008 Mycotoxins are secondary metabolites of moulds that which exert adverse effects in humans and animals. It is known that direct cellular toxicity is often associated with increased cellular accumulation of toxic compounds, and membrane transport may be ...
Kittipong Tachampa +9 more
doaj +4 more sources
Impaired Transport Activity of Human Organic Anion Transporters (OATs) and Organic Anion Transporting Polypeptides (OATPs) by Wnt Inhibitors [PDF]
Journal of Pharmaceutical Sciences, 2021 The Wnt/β-catenin signaling pathway is dysregulated in diseases and Wnt inhibitors like PRI-724 are in clinical development. This study evaluated the regulatory actions of PRI-724 and other Wnt inhibitors on the transport activity of human renal Organic anion transporters (OATs) and Organic anion transporting polypeptides (OATPs).
Wenying Shu, Xiaofeng Bao, Ling Zhu
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Organic Anion Transporter Family: Current Knowledge
Journal of Pharmacological Sciences, 2006 .: Organic anion transporters (OATs) play an essential role in the elimination of numerous endogenous and exogenous organic anions from the body. The renal OATs contribute to the excretion of many drugs and their metabolites that are important in ...
Naohiko Anzai +2 more
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(−)-Epigallocatechin-3-gallate Inhibits Human and Rat Renal Organic Anion Transporters [PDF]
ACS Omega, 2021 Tatsuya Kawasaki +3 more
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Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function [PDF]
American Journal of Physiology - Renal Physiology, 2015 Phylogentically, organic anion transporter (OAT)1 and OAT3 are closely related, whereas OAT2 is more distant. Experiments with human embryonic kidney-293 cells stably transfected with human OAT1, OAT2, or OAT3 were performed to compare selected transport properties. Common to OAT1, OAT2, and OAT3 is their ability to transport cGMP. OAT2 interacted with
Yohannes Hagos +2 more
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