Oral Proteasomal Inhibitors Ixazomib, Oprozomib, and Delanzomib Upregulate the Function of Organic Anion Transporter 3 (OAT3): Implications in OAT3-Mediated Drug-Drug Interactions [PDF]
Pharmaceutics, 2021 Organic anion transporter 3 (OAT3) is mainly expressed at the basolateral membrane of kidney proximal tubules, and is involved in the renal elimination of various kinds of important drugs, potentially affecting drug efficacy or toxicity.
Yunzhou Fan +3 more
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Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3
Molecules, 2023 Organic anion transporter 3 (OAT3) is predominantly expressed in the kidney and plays a vital role in drug clearance. Consequently, co-ingestion of two OAT3 substrates may alter the pharmacokinetics of the substrate.
Ying Chen +3 more
doaj +3 more sources
Palmitoylation Transduces the Regulation of Epidermal Growth Factor to Organic Anion Transporter 3 [PDF]
PharmaceuticsBackground: Organic anion transporter 3 (OAT3) in the kidney proximal tubule cells plays a critical role in renal clearance of numerous endogenous metabolites and exogenous drugs and toxins. In this study, we discovered that epidermal growth factor (EGF)
Zhou Yu +3 more
doaj +2 more sources
Frontiers in Pharmacology, 2020 Enalaprilat is the active metabolite of enalapril, a widely used antihypertension drug. The human organic anion transporter 3 (OAT3), which is highly expressed in the kidney, plays a critical role in the renal clearance of many drugs.
Chunshan Gui, Hongjian Zhang
exaly +3 more sources
Matrix Approach Assessment of Cabotegravir Drug–Drug Interactions with OAT1/OAT3 Substrates and UGT1A1/UGT1A9 Inhibitors Using Physiologically-Based Pharmacokinetic Modeling [PDF]
PharmaceuticsBackground/Objective: Cabotegravir (CAB), available as an oral tablet and as a long-acting (LA) nanosuspension for intramuscular injection, is approved as a combination therapy for the treatment, and as a monotherapy for the prevention, of HIV-1 ...
Helen Tracey +6 more
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Pharmaceutics, 2020 Acamprosate is an anionic drug substance widely used in treating symptoms of alcohol withdrawal. It was recently shown that oral acamprosate absorption is likely due to paracellular transport.
Irina-Elena Antonescu +2 more
exaly +3 more sources
Bempedoic Acid, the First-in-Class Oral ATP Citrate Lyase Inhibitor with Hypocholesterolemic Activity: Clinical Pharmacology and Drug–Drug Interactions [PDF]
PharmaceuticsBempedoic acid is a new drug that improves the control of cholesterol levels, either as monotherapy or in combination with existing lipid-lowering therapies, and shows clinical efficacy in cardiovascular disease patients.
Nicola Ferri +2 more
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Pyridoxic Acid as Endogenous Biomarker of Renal Organic Anion Transporter Activity: Population Variability and Mechanistic Modeling to Predict Drug–Drug Interactions [PDF]
CPT: Pharmacometrics & Systems PharmacologyPyridoxic acid (PDA) was suggested as a potential endogenous biomarker to assess in vivo renal organic anion transporter (OAT) 1 and 3 activity. Here, we first investigated the population variability in the plasma baseline levels of PDA using data from ...
Aarzoo Thakur +3 more
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Pharmaceutics, 2023 Organic anion transporter 3 (OAT3), at the basolateral membrane of kidney proximal tubule cells, facilitates the elimination of numerous widely used drugs.
Zhengxuan Liang, Guofeng You
doaj +1 more source
Novel (sulfated) thyroid hormone transporters in the solute carrier 22 family
European Thyroid Journal, 2023 Objective: Thyroid hormone (TH) transport represents a critical first step in governing intracellular TH regulation. It is still unknown whether the full repertoire of TH transporters has been identified.
Zhongli Chen +11 more
doaj +1 more source