Results 1 to 10 of about 3,190 (115)

Matrix Approach Assessment of Cabotegravir Drug–Drug Interactions With OAT1/OAT3 Substrates and UGT1A1/UGT1A9 Inhibitors Using Physiologically-Based Pharmacokinetic Modeling [PDF]

Pharmaceutics
Background/Objective: Cabotegravir (CAB), available as an oral tablet and as a long-acting (LA) nanosuspension for intramuscular injection, is approved as a combination therapy for the treatment, and as a monotherapy for the prevention, of HIV-1 ...
Simon T Bate, Kunal S Taskar, Aarti Patel   +2 more
exaly   +4 more sources

Identification of Structural Features for the Inhibition of OAT3-Mediated Uptake of Enalaprilat by Selected Drugs and Flavonoids

Frontiers in Pharmacology, 2020
Enalaprilat is the active metabolite of enalapril, a widely used antihypertension drug. The human organic anion transporter 3 (OAT3), which is highly expressed in the kidney, plays a critical role in the renal clearance of many drugs.
Chunshan Gui, Hongjian Zhang
exaly   +3 more sources

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 Without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug–Drug Interactions

Pharmaceutics, 2020
Acamprosate is an anionic drug substance widely used in treating symptoms of alcohol withdrawal. It was recently shown that oral acamprosate absorption is likely due to paracellular transport.
Irina E Antonescu, Carsten Uhd Nielsen, Sibylle Neuhoff   +2 more
exaly   +3 more sources

Palmitoylation Transduces the Regulation of Epidermal Growth Factor to Organic Anion Transporter 3 [PDF]

Pharmaceutics
Background: Organic anion transporter 3 (OAT3) in the kidney proximal tubule cells plays a critical role in renal clearance of numerous endogenous metabolites and exogenous drugs and toxins. In this study, we discovered that epidermal growth factor (EGF)
Zhou Yu, Jinghui Zhang, Jiaxu Feng, Guofeng You   +3 more
doaj   +2 more sources

Oral Proteasomal Inhibitors Ixazomib, Oprozomib, and Delanzomib Upregulate the Function of Organic Anion Transporter 3 (OAT3): Implications in OAT3-Mediated Drug-Drug Interactions

Pharmaceutics, 2021
Organic anion transporter 3 (OAT3) is mainly expressed at the basolateral membrane of kidney proximal tubules, and is involved in the renal elimination of various kinds of important drugs, potentially affecting drug efficacy or toxicity.
Yunzhou Fan, Zhengxuan Liang, Jinghui Zhang, Guofeng You   +3 more
doaj   +1 more source

Chloroquine and Hydroxychloroquine, as Proteasome Inhibitors, Upregulate the Expression and Activity of Organic Anion Transporter 3

Pharmaceutics, 2023
Organic anion transporter 3 (OAT3), at the basolateral membrane of kidney proximal tubule cells, facilitates the elimination of numerous widely used drugs.
Zhengxuan Liang, Guofeng You
doaj   +1 more source

Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3

Molecules, 2023
Organic anion transporter 3 (OAT3) is predominantly expressed in the kidney and plays a vital role in drug clearance. Consequently, co-ingestion of two OAT3 substrates may alter the pharmacokinetics of the substrate.
Ying Chen, Hongyan Li, Ke Wang, Yousheng Wang   +3 more
doaj   +1 more source

Novel (sulfated) thyroid hormone transporters in the solute carrier 22 family

European Thyroid Journal, 2023
Objective: Thyroid hormone (TH) transport represents a critical first step in governing intracellular TH regulation. It is still unknown whether the full repertoire of TH transporters has been identified.
Zhongli Chen, Robin P Peeters, Wesley Flach, Linda J de Rooij, Sena Yildiz, Alexander Teumer, Matthias Nauck, Rosalie B T M Sterenborg, Joost H W Rutten, Marco Medici, W Edward Visser, Marcel E Meima   +11 more
doaj   +1 more source

Interactions of 172 plant extracts with human organic anion transporter 1 (SLC22A6) and 3 (SLC22A8): a study on herb-drug interactions [PDF]

PeerJ, 2017
Background Herb-drug interactions (HDIs) resulting from concomitant use of herbal products with clinical drugs may cause adverse reactions. Organic anion transporter 1 (OAT1) and 3 (OAT3) are highly expressed in the kidney and play a key role in the ...
Hang Lu, Zhiqiang Lu, Xue Li, Gentao Li, Yilin Qiao, Robert P. Borris, Youcai Zhang   +6 more
doaj   +2 more sources

Insulin-like growth factor 1 modulates the phosphorylation, expression, and activity of organic anion transporter 3 through protein kinase A signaling pathway

Acta Pharmaceutica Sinica B, 2020
Organic anion transporter 3 (OAT3) plays a vital role in removing a broad variety of anionic drugs from kidney, thus avoiding their possible toxicity in the body.
Jinghui Zhang, Zhou Yu, Guofeng You
doaj   +1 more source