Results 11 to 20 of about 3,886 (197)

Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3 [PDF]

Journal of Pharmaceutical Sciences, 2021
Human OAT1 and OAT3 play major roles in renal drug elimination and drug-drug interactions. However, there is little information on the interactions of drug metabolites with transporters. The goal of this study was to characterize the interactions of drug
Zur, A. A., Zur, Arik A, Giacomini, Kathleen M, Ngo, H. X., Matsson, Pär,, Stecula, Adrian, Zou, L., Zou, Ling, Matsson, Pär, Ngo, Huy X, Giacomini, K. M., Stecula, A., Kathleen M. Giacomini, Pär Matsson, Huy X. Ngo, Adrian Stecula, Ling Zou, Arik A. Zur   +17 more
core   +6 more sources

Male-dominant activation of rat renal organic anion transporter 1 (Oat1) and 3 (Oat3) expression by transcription factor BCL6. [PDF]

PLoS ONE, 2012
BACKGROUND: Organic anion transporters 1 (Oat1) and 3 (Oat3) mediate the transport of organic anions, including frequently prescribed drugs, across cell membranes in kidney proximal tubule cells.
Waja Wegner, Birgitta Christina Burckhardt, Gerhard Burckhardt, Maja Henjakovic   +3 more
doaj   +3 more sources

Impaired insulin signaling affects renal organic anion transporter 3 (Oat3) function in streptozotocin-induced diabetic rats. [PDF]

PLoS ONE, 2014
Organic anion transporter 3 (Oat3) is a major renal Oats expressed in the basolateral membrane of renal proximal tubule cells. We have recently reported decreases in renal Oat3 function and expression in diabetic rats and these changes were recovered ...
Anusorn Lungkaphin, Phatchawan Arjinajarn, Anchalee Pongchaidecha, Chutima Srimaroeng, Lisa Chatsudthipong, Varanuj Chatsudthipong   +5 more
doaj   +2 more sources

Multispecific Drug Transporter Slc22a8 (Oat3) Regulates Multiple Metabolic and Signaling Pathways [PDF]

Drug Metabolism and Disposition, 2013
Multispecific drug transporters of the solute carrier and ATP-binding cassette families are highly conserved through evolution, but their true physiologic role remains unclear.
Nigam, Sanjay K, Palsson, Bernhard O, Wu, Wei, Jamshidi, Neema, Bush, Kevin T, Eraly, Satish A, Liu, Henry C   +6 more
core   +6 more sources

Dihydrophenanthrenes from Juncus effusus as Inhibitors of OAT1 and OAT3

Journal of Natural Products, 2019
Organic anion transporters 1 (OAT1) and 3 (OAT3) play important roles in the renal elimination of a range of substrate molecules. Little is known about natural products that can modulate OAT1 and OAT3 activities.
Yilin Qiao (6491036), Robert P. Borris (1309752), Xue Wang (102830), Tianxiang Li (6491042), Xue Li (285380), Ruicong Ma (6491039), Youcai Zhang (175270)   +6 more
core   +3 more sources

Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin [PDF]

American Journal of Physiology-Renal Physiology, 2018
The sodium-glucose cotransporter SGLT2 inhibitor empagliflozin (plasma protein binding ~88%) may reach its target in the brush border of the early proximal tubule by glomerular filtration and tubular secretion.
Winnie Huang, Hermann Koepsell, Rohit Patel, Panai Song, Brent Freeman, Falk Batz, Akira Onishi, Davorka Breljak, Volker Vallon, Naohiko Anzai, Yiling Fu, Sanjay K. Nigam, Eric Mayoux, Ivan Sabolic   +13 more
core   +3 more sources

Nano Ellagic Acid Counteracts Cisplatin-Induced Upregulation in OAT1 and OAT3: A Possible Nephroprotection Mechanism

Molecules, 2020
Cisplatin is an anticancer drug commonly used for solid tumors. However, it causes nephrotoxicity. OAT1 and OAT3 are organic anion transporters known to contribute to the uptake of cisplatin into renal tubular cells.
Thikryat Neamatallah, Nagla El-Shitany, Aymn Abbas, Basma G. Eid, Steve Harakeh, Soad Ali, Shaker Mousa   +6 more
doaj   +2 more sources

Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3 [PDF]

Journal of Biological Chemistry, 2021
How organs sense circulating metabolites is a key question. Here, we show that the multispecific organic anion transporters of drugs, OAT1 (SLC22A6 or NKT) and OAT3 (SLC22A8), play a role in organ sensing.
Lewis, Nathan E, Richelle, Anne, Nigam, Sanjay K, Granados, Jeffry C, Bhatnagar, Vibha, Zhang, Xinlian, Gutierrez, Jahir M, Zhang, Patrick, Jeffry C. Granados, Nathan E. Lewis, Xinlian Zhang, Vibha Bhatnagar, Anne Richelle, Jahir M. Gutierrez, Patrick Zhang, Sanjay K. Nigam   +15 more
core   +6 more sources

Prebiotic prevents impaired kidney and renal Oat3 functions in obese rats [PDF]

Journal of Endocrinology, 2018
Obesity is health issue worldwide, which can lead to kidney dysfunction. Prebiotics are non-digestible foods that have beneficial effects on health. This study aimed to investigate the effects of xylooligosaccharide (XOS) on renal function, renal organic
Chaiyavat Chaiyasut, Wannipa Tunapong, Anchalee Pongchaidecha, Varanuj Chatsudthipong, Nipon Chattipakorn, Sakawdaurn Yasom, Parameth Thiennimitr, Siriporn Chattipakorn, Keerati Wanchai, Titikorn Chunchai, Anusorn Lungkaphin   +10 more
core   +3 more sources

In Vivo Regulation of Small Molecule Natural Products, Antioxidants, and Nutrients by OAT1 and OAT3

Nutrients
The organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC22A8) are drug transporters that are expressed in the kidney, with well-established roles in the in vivo transport of drugs and endogenous metabolites.
Geoffrey Chang, Jeffry C. Granados, Jeremiah D. Momper, Koustav Maity, Patrick Zhang, Kian Falah, Sanjay K. Nigam, Anisha K. Nigam   +7 more
core   +4 more sources