Results 11 to 20 of about 5,258 (215)

Nutritional Intervention With Perennial Ryegrass Modulates UA Metabolism in Goslings via Gut Microbiota-Antioxidant Pathway Modulation. [PDF]

Food Sci Nutr
Perennial ryegrass supplementation modulates UA‐metabolism in goslings by reducing serum uric acid and creatinine through inhibition of hepatic xanthine oxidase and upregulation of urate transporters (ABCG2, OAT1, OAT3). It enhances antioxidant capacity via Nrf2 activation, improves intestinal barrier integrity, and enriches beneficial gut microbiota ...
Asif MA, Zulfiqar Z, Mustafa BE, Saif S, Wang Z, Cui Y, Hao S, Boshuai L, Shi Y.   +8 more
europepmc   +2 more sources

Dicloxacillin and Flucloxacillin Inhibit Hepatic Uptake Transporters-In Vitro Investigations and Physiologically Based Pharmacokinetic Modeling. [PDF]

Clin Transl Sci
ABSTRACT Dicloxacillin and flucloxacillin are β‐lactamase‐resistant penicillin antibiotics that have been in clinical use for over 50 years. While both antibiotics are known to induce cytochrome P450 enzymes, there is limited information available regarding their interactions with drug transporters.
Sjöstedt N, Amaeze OU, van den Heuvel JJMW, Stage TB, Koenderink JB, Isoherranen N, Kidron H, Järvinen E.   +7 more
europepmc   +2 more sources

Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3 [PDF]

Journal of Pharmaceutical Sciences, 2021
Human OAT1 and OAT3 play major roles in renal drug elimination and drug-drug interactions. However, there is little information on the interactions of drug metabolites with transporters. The goal of this study was to characterize the interactions of drug metabolites with OAT1 and OAT3 and compare their potencies of inhibition with those of their ...
Zou, Ling, Matsson, Pär, Stecula, Adrian, Ngo, Huy X, Zur, Arik A, Giacomini, Kathleen M   +5 more
openaire   +4 more sources

Lack of Modulation of In Vivo Activity of Organic Anion Transporters 1 and 3 in Pregnancy Using Furosemide as a Probe. [PDF]

J Clin Pharmacol
Abstract Pregnancy induces physiological changes that can alter drug disposition, yet little is known about their impact on renal transporters such as organic anion transporters 1 and 3 (OAT1/3). This study aimed to evaluate the in vivo activity of OAT1/3 during pregnancy using furosemide as a probe substrate.
Vieira JW, Dos Santos Melli PP, Duarte G, Lanchote VL, de Benzi JRL.   +4 more
europepmc   +2 more sources

OAT3 mediates methotrexate resistance in the treatment of rheumatoid arthritis

Biomedicine & Pharmacotherapy, 2022
To study whether organic anion transporter 3 (OAT3) is involved in the development of methotrexate (MTX) resistance in the treatment of rheumatoid arthritis.The experimental components of the animals were the normal group, collagen-induced arthritis (CIA) model group, and MTX treatment group.
Jinzhang, Gao, Ning, Xiao, Qianlei, Wang, Zhengkun, Xu, Feng, Xiao, Zhaoyi, Yang, Wei, Wei, Chun, Wang   +7 more
openaire   +2 more sources

Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity [PDF]

Clinical and Translational Science, 2017
AbstractCisplatin is among the most widely used anticancer drugs and known to cause a dose‐limiting nephrotoxicity, which is partially dependent on the renal uptake carrier OCT2. We here report a previously unrecognized, OCT2‐independent pathway of cisplatin‐induced renal injury that is mediated by the organic anion transporters OAT1 and OAT3.
Hu, S, Leblanc, AF, Gibson, AA, Hong, KW, Kim, JY, Janke, LJ, Li, L, Vasilyeva, A, Finkelstein, DB, Sprowl, JA, Sweet, DH, Schlatter, E, Ciarimboli, G, Schellens, JHM, Baker, SD, Pabla, N, Sparreboom, A   +16 more
openaire   +2 more sources

Interactions of 172 plant extracts with human organic anion transporter 1 (SLC22A6) and 3 (SLC22A8): a study on herb-drug interactions [PDF]

PeerJ, 2017
Background Herb-drug interactions (HDIs) resulting from concomitant use of herbal products with clinical drugs may cause adverse reactions. Organic anion transporter 1 (OAT1) and 3 (OAT3) are highly expressed in the kidney and play a key role in the ...
Hang Lu, Zhiqiang Lu, Xue Li, Gentao Li, Yilin Qiao, Robert P. Borris, Youcai Zhang   +6 more
doaj   +2 more sources

Insulin-like growth factor 1 modulates the phosphorylation, expression, and activity of organic anion transporter 3 through protein kinase A signaling pathway

Acta Pharmaceutica Sinica B, 2020
Organic anion transporter 3 (OAT3) plays a vital role in removing a broad variety of anionic drugs from kidney, thus avoiding their possible toxicity in the body.
Jinghui Zhang, Zhou Yu, Guofeng You
doaj   +1 more source

Male-dominant activation of rat renal organic anion transporter 1 (Oat1) and 3 (Oat3) expression by transcription factor BCL6. [PDF]

PLoS ONE, 2012
BACKGROUND: Organic anion transporters 1 (Oat1) and 3 (Oat3) mediate the transport of organic anions, including frequently prescribed drugs, across cell membranes in kidney proximal tubule cells.
Waja Wegner, Birgitta Christina Burckhardt, Gerhard Burckhardt, Maja Henjakovic   +3 more
doaj   +1 more source

The Prescription of Drugs That Inhibit Organic Anion Transporters 1 or 3 Is Associated with the Plasma Accumulation of Uremic Toxins in Kidney Transplant Recipients

Toxins, 2021
The renal elimination of uremic toxins (UTs) can be potentially altered by drugs that inhibit organic anion transporters 1/3 (OAT1/OAT3). The objective of the present study was to determine whether the prescription of at least one OAT1/OAT3 inhibitor was
Camille André, Touria Mernissi, Gabriel Choukroun, Youssef Bennis, Saïd Kamel, Sophie Liabeuf, Sandra Bodeau   +6 more
doaj   +1 more source