Results 31 to 40 of about 3,886 (197)

OAT3-Mediated Extrusion of the ^99m Tc-ECD Metabolite in the Mouse Brain [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2014
After administration of the 99m Tc complex with N, N'-1,2-ethylenediylbis-L-cysteine diethyl ester ( 99m Tc-ECD), a brain perfusion imaging agent, the radioactive metabolite is trapped in primate brain, but not in mouse and rat. Here, we investigate the
Tatsuya, Kikuchi, Toshimitsu, Okamura, Hidekatsu, Wakizaka, Maki, Okada, Kenichi, Odaka, Joji, Yui, Atsushi B, Tsuji, Toshimitsu, Fukumura, Ming-Rong, Zhang   +8 more
openaire   +2 more sources

Regulation of Renal Organic Anion Transporter 3 (SLC22A8) Expression and Function by the Integrity of Lipid Raft Domains and their Associated Cytoskeleton

Cellular Physiology and Biochemistry, 2013
Background/Aims: In humans and rodents, organic anion transporter 3 (Oat3) is highly expressed on the basolateral membrane of renal proximal tubules and mediates the secretion of exogenous and endogenous anions. Regulation of Oat3 expression and function
Chutima Srimaroeng, Jennifer Perry Cecile, Ramsey Walden, John B. Pritchard   +3 more
doaj   +1 more source

Altered Renal Expression of Relevant Clinical Drug Transporters in Different Models of Acute Uremia in Rats. Role of Urea Levels

Cellular Physiology and Biochemistry, 2015
Background/Aims: Organic anion transporter 1 (Oat1) and 3 (Oat3) are organic anion transporters that play critical roles in the body disposition of numerous clinically important drugs.
Anabel Brandoni, Adriana M. Torres
doaj   +1 more source

Organic anion transporters also mediate the drug–drug interaction between imipenem and cilastatin

Asian Journal of Pharmaceutical Sciences, 2020
This study aimed to clarify that organic anion transporters (OATs) mediate the drug–drug interaction (DDI) between imipenem and cilastatin. After co-administration with imipenem, the plasma concentrations and the plasma concentration-time curve (AUC) of ...
Yanna Zhu, Xiaokui Huo, Changyuan Wang, Qiang Meng, Zhihao Liu, Huijun Sun, Aiping Tan, Xiaodong Ma, Jinyong Peng, Kexin Liu   +9 more
doaj   +1 more source

Expression of OAT1 and OAT3 in differentiating proximal tubules of the mouse kidney.

Histology and histopathology, 2009
Organic anion transporter 1 (OAT1) and OAT3 in the proximal tubules (PT) of the kidney play important roles in the elimination of harmful endogenous compounds and xenobiotics from the body. We investigated the temporal and spatial expression of OAT1 and OAT3 in the differentiating PT in mouse kidney.
Hwang, Jin-Sun, Park, Eun-Young, Kim, W.J., Yang, Chul-Woo, Kim, Jin   +4 more
openaire   +3 more sources

Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions

Scientific Reports, 2022
In vitro and in vivo studies have established the organic anion transporters OAT1 (SLC22A6, NKT) and OAT3 (SLC22A8) among the main multi-specific “drug” transporters.
Neema Jamshidi, Sanjay K. Nigam
doaj   +1 more source

Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3 [PDF]

, 2016
One of the characteristics of chronic kidney disease (CKD) is the accumulation of uremic solutes in the plasma. Less is known about the effects of uremic solutes on transporters that may play critical roles in pharmacokinetics. We evaluated the effect of
Zhao, Ping, Meyer, Timothy W, Ping Zhao (47228), Lei Zhang (38117), Huang, Shiew-Mei, Chia-Hsiang Hsueh (2925417), Shiew-Mei Huang (2925420), Kenta Yoshida (2050486), Zhang, Lei, Kathleen M. Giacomini (259990), Giacomini, Kathleen M, Timothy W. Meyer (2925414), Yoshida, Kenta, Hsueh, Chia-Hsiang   +13 more
core   +1 more source

Transporters (OATs and OATPs) contribute to illustrate the mechanism of medicinal compatibility of ingredients with different properties in yuanhuzhitong prescription

Acta Pharmaceutica Sinica B, 2020
Various medicinal ingredients with different tastes are combined according to the theory of compatibility in Chinese materia medica to achieve a better efficacy, while the mechanism was not very clear.
Ze Wang, Haihua Shang, Yazhuo Li, Chen Zhang, Yan Dong, Tao Cui, Hongbing Zhang, Xiaoyan Ci, Xiulin Yi, Tiejun Zhang, Fengying Yan, Yaping Zhang, Xing Huang, Weidang Wu, Changxiao Liu   +14 more
doaj   +1 more source

Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning [PDF]

Journal of Biological Chemistry, 2020
The multispecific organic anion transporters, OAT1 (SLC22A6) and OAT3 (SLC22A8), the main kidney elimination pathways for many common drugs, are often considered to have largely-redundant roles. However, whereas examination of metabolomics data from Oat-knockout mice (Oat1 and Oat3KO) revealed considerable overlap, over a hundred metabolites were ...
Anisha K. Nigam, Julia G. Li, Kaustubh Lall, Da Shi, Kevin T. Bush, Vibha Bhatnagar, Ruben Abagyan, Sanjay K. Nigam   +7 more
openaire   +4 more sources

Topotecan and Ginkgolic Acid Inhibit the Expression and Transport Activity of Human Organic Anion Transporter 3 by Suppressing SUMOylation of the Transporter

Pharmaceutics
Organic anion transporter 3 (OAT3), expressed at the basolateral membrane of kidney proximal tubule cells, facilitates the elimination of numerous metabolites, environmental toxins, and clinically important drugs.
Zhou Yu, Guofeng You
doaj   +1 more source