Results 1 to 10 of about 3,273 (116)

Estrogen Receptor α (ERα) Indirectly Induces Transcription of Human Renal Organic Anion Transporter 1 (OAT1)

Physiological Reports, 2019
Organic anion transporter 1 (OAT1) is a polyspecific transport protein located in the basolateral membrane of renal proximal tubule cells. OAT1 plays a pivotal role in drug clearance.
Maja Henjakovic, Tamina Seeger-Nukpezah
exaly   +2 more sources

Structural Insights Into Human Polyspecific Organic Anion Transporters OAT1 and OAT4

Cell Reports
Summary: Organic anion transporters (OATs) play a critical role in the transport of organic anions. OAT1, located in the kidney, is essential for the transport of organic anion drugs and metabolites, while OAT4 facilitates absorption processes in the ...
Yanqing Zhang, Jing Nan, Huihui Liu
exaly   +3 more sources

Interactions of 172 plant extracts with human organic anion transporter 1 (SLC22A6) and 3 (SLC22A8): a study on herb-drug interactions [PDF]

PeerJ, 2017
Background Herb-drug interactions (HDIs) resulting from concomitant use of herbal products with clinical drugs may cause adverse reactions. Organic anion transporter 1 (OAT1) and 3 (OAT3) are highly expressed in the kidney and play a key role in the ...
Hang Lu, Zhiqiang Lu, Xue Li, Gentao Li, Yilin Qiao, Robert P. Borris, Youcai Zhang   +6 more
doaj   +2 more sources

Protein kinase C regulates organic anion transporter 1 through phosphorylating ubiquitin ligase Nedd4–2

BMC Molecular and Cell Biology, 2021
Background Organic anion transporter 1 (OAT1) is a drug transporter expressed on the basolateral membrane of the proximal tubule cells in kidneys.
Zhou Yu, Chenchang Liu, Jinghui Zhang, Zhengxuan Liang, Guofeng You   +4 more
doaj   +1 more source

Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters

CPT: Pharmacometrics & Systems Pharmacology, 2021
Renal clearance of many drugs is mediated by renal organic anion transporters OAT1/3 and inhibition of these transporters may lead to drug‐drug interactions (DDIs).
Amais Ahmad, Kayode Ogungbenro, Annett Kunze, Frank Jacobs, Jan Snoeys, Amin Rostami‐Hodjegan, Aleksandra Galetin   +6 more
doaj   +1 more source

Male-dominant activation of rat renal organic anion transporter 1 (Oat1) and 3 (Oat3) expression by transcription factor BCL6. [PDF]

PLoS ONE, 2012
BACKGROUND: Organic anion transporters 1 (Oat1) and 3 (Oat3) mediate the transport of organic anions, including frequently prescribed drugs, across cell membranes in kidney proximal tubule cells.
Waja Wegner, Birgitta Christina Burckhardt, Gerhard Burckhardt, Maja Henjakovic   +3 more
doaj   +1 more source

The Prescription of Drugs That Inhibit Organic Anion Transporters 1 or 3 Is Associated with the Plasma Accumulation of Uremic Toxins in Kidney Transplant Recipients

Toxins, 2021
The renal elimination of uremic toxins (UTs) can be potentially altered by drugs that inhibit organic anion transporters 1/3 (OAT1/OAT3). The objective of the present study was to determine whether the prescription of at least one OAT1/OAT3 inhibitor was
Camille André, Touria Mernissi, Gabriel Choukroun, Youssef Bennis, Saïd Kamel, Sophie Liabeuf, Sandra Bodeau   +6 more
doaj   +1 more source

The kidney drug transporter OAT1 regulates gut microbiome–dependent host metabolism

JCI Insight, 2023
Organic anion transporter 1 (OAT1/SLC22A6, NKT) is a multispecific drug transporter in the kidney with numerous substrates, including pharmaceuticals, endogenous metabolites, natural products, and uremic toxins.
Jeffry C. Granados, Vladimir Ermakov, Koustav Maity, David R. Vera, Geoffrey Chang, Sanjay K. Nigam   +5 more
doaj   +1 more source

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug–Drug Interactions

Pharmaceutics, 2020
Acamprosate is an anionic drug substance widely used in treating symptoms of alcohol withdrawal. It was recently shown that oral acamprosate absorption is likely due to paracellular transport.
Irina E. Antonescu, Maria Karlgren, Maria L. Pedersen, Ivailo Simoff, Christel A. S. Bergström, Sibylle Neuhoff, Per Artursson, Bente Steffansen, Carsten Uhd Nielsen   +8 more
doaj   +1 more source

Albumin-bound kynurenic acid is an appropriate endogenous biomarker for assessment of the renal tubular OATs-MRP4 channel

Journal of Pharmaceutical Analysis, 2023
Renal tubular secretion mediated by organic anion transporters (OATs) and the multidrug resistance-associated protein 4 (MRP4) is an important means of drug and toxin excretion. Unfortunately, there are no biomarkers to evaluate their function.
Yanrong Ma, Fenglin Ran, Mingyan Xin, Xueyan Gou, Xinyi Wang, Xinan Wu   +5 more
doaj   +1 more source