Results 1 to 10 of about 5,743 (215)

Estrogen receptor α (ERα) indirectly induces transcription of human renal organic anion transporter 1 (OAT1)

Physiological Reports, 2019
Organic anion transporter 1 (OAT1) is a polyspecific transport protein located in the basolateral membrane of renal proximal tubule cells. OAT1 plays a pivotal role in drug clearance.
Tamina Seeger-Nukpezah, Maja Henjakovic
exaly   +2 more sources

Renal organic anion transporter 1: clinical relevance and the underlying mechanisms in chronic kidney disease [PDF]

BMC Nephrology
Organic anion transporter 1 (OAT1), primarily found in the renal proximal tubule, is essential for the excretion of various uremic toxins that contribute to the onset and progression of chronic kidney disease (CKD).
Changfang You, Jianchun Guo, Yunhao Xun
doaj   +2 more sources

Matrix Approach Assessment of Cabotegravir Drug–Drug Interactions with OAT1/OAT3 Substrates and UGT1A1/UGT1A9 Inhibitors Using Physiologically-Based Pharmacokinetic Modeling [PDF]

Pharmaceutics
Background/Objective: Cabotegravir (CAB), available as an oral tablet and as a long-acting (LA) nanosuspension for intramuscular injection, is approved as a combination therapy for the treatment, and as a monotherapy for the prevention, of HIV-1 ...
Helen Tracey, Simon T. Bate, Susan Ford, Parul Patel, Jackie Bloomer, Aarti Patel, Kunal S. Taskar   +6 more
doaj   +2 more sources

Evaluation of Adefovir PBPK Model to Assess Biomarker‐Informed OAT1 Drug–Drug Interaction and Effect of Chronic Kidney Disease [PDF]

CPT: Pharmacometrics & Systems Pharmacology
Evaluation of transporter‐mediated drug–drug interactions (DDI) with endogenous biomarkers, coupled with physiologically‐based pharmacokinetic modeling (PBPK) is envisioned to replace or reduce dedicated DDI clinical trials with clinical probe substrates.
Shawn Pei Feng Tan, Huaying Wu, Amin Rostami‐Hodjegan, Daniel Scotcher, Aleksandra Galetin   +4 more
doaj   +2 more sources

Comparative Analysis of Proximal Tubule Cell Sources for In Vitro Studies of Renal Proximal Tubule Toxicity [PDF]

Biomedicines
Background/Objectives: The kidneys are essential for eliminating drugs and chemicals from the human body and renal epithelial cells are particularly vulnerable to damage caused by xenobiotics and their metabolites. Drug-induced kidney toxicity is a major
Courtney Sakolish, Han-Hsuan D. Tsai, Hsing-Chieh Lin, Piyush Bajaj, Remi Villenave, Stephen S. Ferguson, Jason P. Stanko, Richard A. Becker, Philip Hewitt, Weihsueh A. Chiu, Ivan Rusyn   +10 more
doaj   +2 more sources

Furosemide and Serum Protein-Bound Uremic Toxin Concentrations in Patients With CKD [PDF]

Kidney International Reports
Introduction: Furosemide is commonly prescribed to patients with chronic kidney disease (CKD) but may impair the kidney’s excretion of protein-bound uremic toxins (PBUTs) via the organic anion transporters 1 and 3 (OAT1 and OAT3).
Margaux Costes-Albrespic, Natalia Alencar de Pinho, Islam Amine Larabi, Carolla El Chamieh, Solène M. Laville, Denis Fouque, Maurice Laville, Luc Frimat, Jean-Claude Alvarez, Ziad A. Massy, Sophie Liabeuf, Natalia Alencar De Pinho, Dorothée Cannet, Christian Combe, Denis Fouque, Luc Frimat, Aghilès Hamroun, Yves-Edouard Herpe, Christian Jacquelinet, Maurice Laville, Sophie Liabeuf, Ziad A. Massy, Pascal Morel, Christophe Pascal, Roberto Pecoits-Filho, Joost Schanstra, Bénédicte Stengel, Céline Lange, Oriane Lambert, Marie Metzger   +29 more
doaj   +2 more sources

Interactions of 172 plant extracts with human organic anion transporter 1 (SLC22A6) and 3 (SLC22A8): a study on herb-drug interactions [PDF]

PeerJ, 2017
Background Herb-drug interactions (HDIs) resulting from concomitant use of herbal products with clinical drugs may cause adverse reactions. Organic anion transporter 1 (OAT1) and 3 (OAT3) are highly expressed in the kidney and play a key role in the ...
Hang Lu, Zhiqiang Lu, Xue Li, Gentao Li, Yilin Qiao, Robert P. Borris, Youcai Zhang   +6 more
doaj   +2 more sources

Protein kinase C regulates organic anion transporter 1 through phosphorylating ubiquitin ligase Nedd4–2

BMC Molecular and Cell Biology, 2021
Background Organic anion transporter 1 (OAT1) is a drug transporter expressed on the basolateral membrane of the proximal tubule cells in kidneys.
Zhou Yu, Chenchang Liu, Jinghui Zhang, Zhengxuan Liang, Guofeng You   +4 more
doaj   +1 more source

Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters

CPT: Pharmacometrics & Systems Pharmacology, 2021
Renal clearance of many drugs is mediated by renal organic anion transporters OAT1/3 and inhibition of these transporters may lead to drug‐drug interactions (DDIs).
Amais Ahmad, Kayode Ogungbenro, Annett Kunze, Frank Jacobs, Jan Snoeys, Amin Rostami‐Hodjegan, Aleksandra Galetin   +6 more
doaj   +1 more source

Male-dominant activation of rat renal organic anion transporter 1 (Oat1) and 3 (Oat3) expression by transcription factor BCL6. [PDF]

PLoS ONE, 2012
BACKGROUND: Organic anion transporters 1 (Oat1) and 3 (Oat3) mediate the transport of organic anions, including frequently prescribed drugs, across cell membranes in kidney proximal tubule cells.
Waja Wegner, Birgitta Christina Burckhardt, Gerhard Burckhardt, Maja Henjakovic   +3 more
doaj   +1 more source