Results 11 to 20 of about 4,120 (207)

A key role for the transporter OAT1 in systemic lipid metabolism [PDF]

Journal of Biological Chemistry, 2021
Organic anion transporter 1 (OAT1/SLC22A6) is a drug transporter with numerous xenobiotic and endogenous substrates. The Remote Sensing and Signaling Theory suggests that drug transporters with compatible ligand preferences can play a role in "organ crosstalk," mediating overall organismal communication.
Jeffry C. Granados, Anisha K. Nigam, Kevin T. Bush, Neema Jamshidi, Sanjay K. Nigam   +4 more
openaire   +6 more sources

An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network [PDF]

Journal of Biological Chemistry, 2016
There has been a recent interest in the broader physiological importance of multispecific "drug" transporters of the SLC and ABC transporter families. Here, a novel multi-tiered systems biology approach was used to predict metabolites and signaling molecules potentially affected by the in vivo deletion of organic anion transporter 1 (Oat1, Slc22a6 ...
Liu, Henry C, Jamshidi, Neema, Chen, Yuchen, Eraly, Satish A, Cho, Sai Yee, Bhatnagar, Vibha, Wu, Wei, Bush, Kevin T, Abagyan, Ruben, Palsson, Bernhard O, Nigam, Sanjay K   +10 more
openaire   +6 more sources

Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3 [PDF]

Journal of Biological Chemistry, 2021
How organs sense circulating metabolites is a key question. Here, we show that the multispecific organic anion transporters of drugs, OAT1 (SLC22A6 or NKT) and OAT3 (SLC22A8), play a role in organ sensing. Metabolomics analyses of the serum of Oat1 and Oat3 knockout mice revealed changes in tryptophan derivatives involved in metabolism and signaling ...
Jeffry C. Granados, Anne Richelle, Jahir M. Gutierrez, Patrick Zhang, Xinlian Zhang, Vibha Bhatnagar, Nathan E. Lewis, Sanjay K. Nigam   +7 more
openaire   +6 more sources

Dihydrophenanthrenes from Juncus effusus as Inhibitors of OAT1 and OAT3

Journal of Natural Products, 2019
Organic anion transporters 1 (OAT1) and 3 (OAT3) play important roles in the renal elimination of a range of substrate molecules. Little is known about natural products that can modulate OAT1 and OAT3 activities. The medullae of Juncus effusus is often used for the treatment of dysuria in traditional Chinese medicine.
Xue Li, Yilin Qiao, Xue Wang, Ruicong Ma, Tianxiang Li, Youcai Zhang, Robert P. Borris   +6 more
openaire   +3 more sources

Nano Ellagic Acid Counteracts Cisplatin-Induced Upregulation in OAT1 and OAT3: A Possible Nephroprotection Mechanism

Molecules, 2020
Cisplatin is an anticancer drug commonly used for solid tumors. However, it causes nephrotoxicity. OAT1 and OAT3 are organic anion transporters known to contribute to the uptake of cisplatin into renal tubular cells.
Thikryat Neamatallah, Nagla El-Shitany, Aymn Abbas, Basma G. Eid, Steve Harakeh, Soad Ali, Shaker Mousa   +6 more
doaj   +2 more sources

β-Lactam Antibiotics—Drug-Drug Interaction Mediated by Organic Anion Transporters OAT1 and OAT3 [PDF]

Регуляторные исследования и экспертиза лекарственных средств, 2020
Organic anion transporters OAT1 and OAT3 play a key role in elimination of most β-lactam antibiotics. Since nonsteroidal anti-inflammatory drugs, antivirals, antitumor agents, and some other drugs are also substrates of OAT1/3, this enables drug-drug ...
I. A. Mazerkina, V. A. Evteev, A. B. Prokofiev, O. V. Muslimova, E. Yu. Demchenkova   +4 more
doaj   +2 more sources

Distribution of organic anion transporters NaDC3 and OAT1-3 along the human nephron [PDF]

American Journal of Physiology-Renal Physiology, 2016
The initial step in renal secretion of organic anions (OAs) is mediated by transporters in the basolateral membrane (BLM). Contributors to this process are primary active Na+-K+-ATPase (EC 3.6.3.9), secondary active Na+-dicarboxylate cotransporter 3 (NaDC3/SLC13A3), and tertiary active OA transporters (OATs) OAT1/SLC22A6, OAT2/SLC22A7, and OAT3/SLC22A8.
Breljak, Davorka, Ljubojevic, Marija, Hagos, Yohannes, Micek, Vedran, Eror, Daniela Balen, Madunic, Ivana Vrhovac, Brzica, Hrvoje, Karaica, Dean, Radovic, Nikola, Kraus, Ognjen, Anzai, Naohiko, Koepsell, Hermann, Burckhardt, Gerhard, Burckhardt, Birgitta-Christina, Sabolic, Ivan   +14 more
openaire   +6 more sources

Evaluation of Adefovir PBPK Model to Assess Biomarker‐Informed OAT1 Drug–Drug Interaction and Effect of Chronic Kidney Disease

CPT: Pharmacometrics & Systems Pharmacology
Evaluation of transporter‐mediated drug–drug interactions (DDI) with endogenous biomarkers, coupled with physiologically‐based pharmacokinetic modeling (PBPK) is envisioned to replace or reduce dedicated DDI clinical trials with clinical probe substrates.
Shawn Pei Feng Tan, Huaying Wu, Amin Rostami‐Hodjegan, Daniel Scotcher, Aleksandra Galetin   +4 more
doaj   +2 more sources

Renal organic anion transporter 1: clinical relevance and the underlying mechanisms in chronic kidney disease

BMC Nephrology
Organic anion transporter 1 (OAT1), primarily found in the renal proximal tubule, is essential for the excretion of various uremic toxins that contribute to the onset and progression of chronic kidney disease (CKD).
Changfang You, Jianchun Guo, Yunhao Xun
doaj   +2 more sources

Matrix Approach Assessment of Cabotegravir Drug–Drug Interactions with OAT1/OAT3 Substrates and UGT1A1/UGT1A9 Inhibitors Using Physiologically-Based Pharmacokinetic Modeling

Pharmaceutics
Background/Objective: Cabotegravir (CAB), available as an oral tablet and as a long-acting (LA) nanosuspension for intramuscular injection, is approved as a combination therapy for the treatment, and as a monotherapy for the prevention, of HIV-1 ...
Helen Tracey, Simon T. Bate, Susan Ford, Parul Patel, Jackie Bloomer, Aarti Patel, Kunal S. Taskar   +6 more
doaj   +2 more sources