Results 11 to 20 of about 5,743 (215)

The kidney drug transporter OAT1 regulates gut microbiome–dependent host metabolism [PDF]

JCI Insight, 2023
Organic anion transporter 1 (OAT1/SLC22A6, NKT) is a multispecific drug transporter in the kidney with numerous substrates, including pharmaceuticals, endogenous metabolites, natural products, and uremic toxins.
Jeffry C. Granados, Vladimir Ermakov, Koustav Maity, David R. Vera, Geoffrey Chang, Sanjay K. Nigam   +5 more
doaj   +4 more sources

Structural insights into human polyspecific organic anion transporters OAT1 and OAT4

Cell Reports
Summary: Organic anion transporters (OATs) play a critical role in the transport of organic anions. OAT1, located in the kidney, is essential for the transport of organic anion drugs and metabolites, while OAT4 facilitates absorption processes in the ...
Wei Zhang, Youfu Chu, Ziyang Shan, Huihui Liu, Xuemei Yang, Jing Nan, Feiwen Wei, Yanqing Zhang   +7 more
doaj   +2 more sources

Nutritional Intervention With Perennial Ryegrass Modulates UA Metabolism in Goslings via Gut Microbiota-Antioxidant Pathway Modulation. [PDF]

Food Sci Nutr
Perennial ryegrass supplementation modulates UA‐metabolism in goslings by reducing serum uric acid and creatinine through inhibition of hepatic xanthine oxidase and upregulation of urate transporters (ABCG2, OAT1, OAT3). It enhances antioxidant capacity via Nrf2 activation, improves intestinal barrier integrity, and enriches beneficial gut microbiota ...
Asif MA, Zulfiqar Z, Mustafa BE, Saif S, Wang Z, Cui Y, Hao S, Boshuai L, Shi Y.   +8 more
europepmc   +2 more sources

Lack of Modulation of In Vivo Activity of Organic Anion Transporters 1 and 3 in Pregnancy Using Furosemide as a Probe. [PDF]

J Clin Pharmacol
Abstract Pregnancy induces physiological changes that can alter drug disposition, yet little is known about their impact on renal transporters such as organic anion transporters 1 and 3 (OAT1/3). This study aimed to evaluate the in vivo activity of OAT1/3 during pregnancy using furosemide as a probe substrate.
Vieira JW, Dos Santos Melli PP, Duarte G, Lanchote VL, de Benzi JRL.   +4 more
europepmc   +2 more sources

Serine encodes drug selectivity in human OAT1. [PDF]

Structure
Dai Y, Lee CH.
europepmc   +2 more sources

A key role for the transporter OAT1 in systemic lipid metabolism [PDF]

Journal of Biological Chemistry, 2021
Organic anion transporter 1 (OAT1/SLC22A6) is a drug transporter with numerous xenobiotic and endogenous substrates. The Remote Sensing and Signaling Theory suggests that drug transporters with compatible ligand preferences can play a role in "organ crosstalk," mediating overall organismal communication.
Jeffry C. Granados, Anisha K. Nigam, Kevin T. Bush, Neema Jamshidi, Sanjay K. Nigam   +4 more
openaire   +4 more sources

Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3 [PDF]

Journal of Pharmaceutical Sciences, 2021
Human OAT1 and OAT3 play major roles in renal drug elimination and drug-drug interactions. However, there is little information on the interactions of drug metabolites with transporters. The goal of this study was to characterize the interactions of drug metabolites with OAT1 and OAT3 and compare their potencies of inhibition with those of their ...
Zou, Ling, Matsson, Pär, Stecula, Adrian, Ngo, Huy X, Zur, Arik A, Giacomini, Kathleen M   +5 more
openaire   +4 more sources

Dicloxacillin and Flucloxacillin Inhibit Hepatic Uptake Transporters-In Vitro Investigations and Physiologically Based Pharmacokinetic Modeling. [PDF]

Clin Transl Sci
ABSTRACT Dicloxacillin and flucloxacillin are β‐lactamase‐resistant penicillin antibiotics that have been in clinical use for over 50 years. While both antibiotics are known to induce cytochrome P450 enzymes, there is limited information available regarding their interactions with drug transporters.
Sjöstedt N, Amaeze OU, van den Heuvel JJMW, Stage TB, Koenderink JB, Isoherranen N, Kidron H, Järvinen E.   +7 more
europepmc   +2 more sources

An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network [PDF]

Journal of Biological Chemistry, 2016
There has been a recent interest in the broader physiological importance of multispecific "drug" transporters of the SLC and ABC transporter families. Here, a novel multi-tiered systems biology approach was used to predict metabolites and signaling molecules potentially affected by the in vivo deletion of organic anion transporter 1 (Oat1, Slc22a6 ...
Liu, Henry C, Jamshidi, Neema, Chen, Yuchen, Eraly, Satish A, Cho, Sai Yee, Bhatnagar, Vibha, Wu, Wei, Bush, Kevin T, Abagyan, Ruben, Palsson, Bernhard O, Nigam, Sanjay K   +10 more
openaire   +4 more sources

Role of Glycosylation in the Organic Anion Transporter OAT1 [PDF]

Journal of Biological Chemistry, 2004
Organic anion transporters (OAT) play essential roles in the body disposition of clinically important anionic drugs, including antiviral drugs, antitumor drugs, antibiotics, antihypertensives, and anti-inflammatories. We reported previously (Kuze, K., Graves, P., Leahy, A., Wilson, P., Stuhlmann, H., and You, G. (1999) J. Biol. Chem.
Kunihiko, Tanaka, Wen, Xu, Fanfan, Zhou, Guofeng, You   +3 more
openaire   +2 more sources