Results 31 to 40 of about 4,120 (207)
Remote effects of kidney drug transporter OAT1 on gut microbiome composition and urate homeostasis
JCI Insight, 2023 The organic anion transporter OAT1 (SLC22A6, originally identified as NKT) is a multispecific transporter responsible for the elimination by the kidney of small organic anions that derive from the gut microbiome.
Vladimir S. Ermakov +2 more
doaj +1 more source
Pharmaceutics, 2022 Background: Organic anion transporter 1 (OAT1) and OAT3 have an overlapping spectrum of substrates such that one can exert a compensatory effect when the other is dysfunctional.
Xueyan Gou +4 more
doaj +1 more source
Drugs Commonly Applied to Kidney Patients May Compromise Renal Tubular Uremic Toxins Excretion
Toxins, 2020 In chronic kidney disease (CKD), the secretion of uremic toxins is compromised leading to their accumulation in blood, which contributes to uremic complications, in particular cardiovascular disease.
Silvia M. Mihaila +6 more
doaj +1 more source
Tenofovir renal proximal tubular toxicity is regulated By OAT1 and MRP4 transporters [PDF]
Laboratory Investigation, 2011 Tenofovir disoproxil fumarate (TDF) is an oral prodrug and acyclic nucleotide analog of adenosine monophosphate that inhibits HIV-1 (HIV) reverse transcriptase. A growing subset of TDF-treated HIV(+) individuals presented with acute renal failure, suggesting tenofovir-associated kidney-specific toxicity.
Kohler, James J. +7 more
openaire +2 more sources
Regulation of Solute Carriers OCT2 and OAT1/3 in the Kidney
Physiological Reviews, 2022 Over the course of more than 500 million years, the kidneys have undergone a remarkable evolution from primitive nephric tubes to intricate filtration-reabsorption systems that maintain homeostasis and remove metabolic end products from the body.
Pou Casellas, Carla +5 more
openaire +6 more sources
Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1
Nature Structural & Molecular Biology, 2023 Abstract In mammals, the kidney plays an essential role in maintaining blood homeostasis through the selective uptake, retention or elimination of toxins, drugs and metabolites. Organic anion transporters (OATs) are responsible for the recognition of metabolites and toxins in the nephron and their eventual urinary excretion ...
Parker, JL +4 more
openaire +2 more sources
Cellular Physiology and Biochemistry, 2015 Background/Aims: Organic anion transporter 1 (Oat1) and 3 (Oat3) are organic anion transporters that play critical roles in the body disposition of numerous clinically important drugs.
Anabel Brandoni, Adriana M. Torres
doaj +1 more source
Journal of Pharmacological Sciences, 2021 Islatravir (ISL; 4′-ethynyl-2-fluoro-2′-deoxyadenosine or EFdA) is a novel reverse transcriptase translocation inhibitor and has a unique structure and high antiviral activity against wild-type and multidrug resistant HIV strains.
Meika Kaneko +9 more
doaj +1 more source
α-Ketoglutarate-related inhibitors of HIF prolyl hydroxylases are substrates of renal organic anion transporters 1 (OAT1) and 4 (OAT4) [PDF]
, 2012 2-Oxoglutarate or alpha-ketoglutarate (alpha KG) is a substrate of HIF prolyl hydroxylases 1-3 that decrease cellular levels of the hypoxia-inducible factor 1 alpha (HIF-1 alpha) in the presence of oxygen.
Wolfgang Krick +13 more
core +1 more source
, 2021 Supplementary tables describing OAT1/3 inhibition, accuracy and precision data, and stability ...
David Rodrigues (122029) +4 more
core +1 more source