Results 51 to 60 of about 4,120 (207)

Development of 4-Pyridoxic Acid PBPK Model to Support Biomarker- Informed Evaluation of OAT1/3 Inhibition and Effect of Chronic Kidney Disease [PDF]

, 2023
Monitoring endogenous biomarkers is increasingly used to evaluate transporter-mediated drug-drug interactions (DDIs) in early drug development and may be applied to elucidate changes in transporter activity in disease.
Shawn Pei Feng Tan, Jan Snoeys, Hong Shen, Rostami‐hodjegan, Amin, Scotcher, Daniel; id_orcid, Shen, Hong, Amin Rostami‐Hodjegan, Daniel Scotcher, Willemin, Marie‐emilie, Tan, Shawn pei feng, Galetin, Aleksandra, Aleksandra Galetin, Snoeys, Jan, Marie‐Emilie Willemin   +13 more
core   +1 more source

Estimating the Private Value of Financial Statement Statistics Estimation de la valeur privée des statistiques des états financiers

Contemporary Accounting Research, EarlyView.
ABSTRACT We develop a method for estimating the private value of knowing the future realization of some financial statistics, and then we apply the measure to the familiar ratios from the DuPont decomposition of return on equity. The estimation is grounded in the standard rational expectations model, adapted to accommodate relative risk aversion, and ...
Russell Lundholm, Xin Zheng
wiley   +1 more source

Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule. [PDF]

PLoS ONE, 2012
Proper physiological function in the pre- and post-natal proximal tubule of the kidney depends upon the acquisition of selective permeability, apical-basolateral epithelial polarity and the expression of key transporters, including those involved in ...
Thomas F Gallegos, Gleb Martovetsky, Valentina Kouznetsova, Kevin T Bush, Sanjay K Nigam   +4 more
doaj   +1 more source

Human organic anion transporter OAT1 is not responsible for glutathione transport but mediates transport of glutamate derivatives

, 2013
Hagos Y, Burckhardt G, Burckhardt BC. Human organic anion transporter OAT1 is not responsible for glutathione transport but mediates transport of glutamate derivatives. Am J Physiol Renal Physiol 304: F403-F409, 2013.
Burckhardt, Gerhard, Burckhardt, Birgitta-Christina, Hagos, Yohannes   +2 more
core   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Industry Perspective on Current Guidelines, Challenges, and Future Directions for ADME Characterization of Payloads for Antibody‐Drug Conjugates

Pharmacology Research &Perspectives, Volume 14, Issue 6, December 2026.
ABSTRACT A total of 15 antibody‐drug conjugates (ADC)s have been approved by USFDA till December 2025 with the use of nine cytotoxic payload molecules. Small molecule payloads can undergo enzymatic or nonenzymatic biotransformation, distribution, protein or red blood cell binding, transporter mediated disposition and urinary and/or biliary‐fecal ...
Vijay More, Kiran Deshpande, Chaitali Passey, Gaurav Bajaj, Jeff Barrett, Manish Gupta   +5 more
wiley   +1 more source

Antidiabetic and Renoprotective Effects of Cladophora glomerata Kützing Extract in Experimental Type 2 Diabetic Rats: A Potential Nutraceutical Product for Diabetic Nephropathy

Journal of Diabetes Research, 2015
Cladophora glomerata extract (CGE) has been shown to exhibit antigastric ulcer, anti-inflammatory, analgesic, hypotensive, and antioxidant activities.
Chutima Srimaroeng, Atcharaporn Ontawong, Naruwan Saowakon, Pornpun Vivithanaporn, Anchalee Pongchaidecha, Doungporn Amornlerdpison, Sunhapas Soodvilai, Varanuj Chatsudthipong   +7 more
doaj   +1 more source

ATP/ADP biosensor organoids for drug nephrotoxicity assessment

Frontiers in Cell and Developmental Biology, 2023
Drug nephrotoxicity is a common healthcare problem in hospitalized patients and a major limitation during drug development. Multi-segmented kidney organoids derived from human pluripotent stem cells may complement traditional cell culture and animal ...
Koichiro Susa, Koichiro Susa, Koichiro Susa, Kenichi Kobayashi, Kenichi Kobayashi, Pierre Galichon, Pierre Galichon, Takuya Matsumoto, Takuya Matsumoto, Takuya Matsumoto, Akitoshi Tamura, Ken Hiratsuka, Ken Hiratsuka, Ken Hiratsuka, Ken Hiratsuka, Navin R. Gupta, Navin R. Gupta, Navin R. Gupta, Iman K. Yazdi, Iman K. Yazdi, Iman K. Yazdi, Iman K. Yazdi, Joseph V. Bonventre, Joseph V. Bonventre, Joseph V. Bonventre, Joseph V. Bonventre, Ryuji Morizane, Ryuji Morizane, Ryuji Morizane, Ryuji Morizane, Ryuji Morizane   +30 more
doaj   +1 more source

Pediatric Developmental Safety Assessment and New Approach Methodologies: US FDA/Triangle CERSI Workshop Report

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1240-1249, November 2026.
Pediatric developmental safety assessment presents distinct challenges in drug development. Children undergo dynamic changes in organ systems and drug disposition pathways during development, and drug‐related effects may be delayed or manifested differently than in adults.
Gilbert J. Burckart, Gelareh Abulwerdi, Christin L. Daniels, Calib Choi, Rebecca Racz, Jean‐Pierre Valentin, Kristin Ardlie, Nicholas Tatonetti, Susan Laffan, Marjory Moreau, Will Redfern, Lang Li, James J. Hickman, Rajanikanth Madabushi, Bhagwat Prasad, Lynne Yao, Paul B. Watkins   +16 more
wiley   +1 more source

3D proximal tubule-on-chip model derived from kidney organoids with improved drug uptake

Scientific Reports, 2022
Three-dimensional, organ-on-chip models that recapitulate kidney tissue are needed for drug screening and disease modeling. Here, we report a method for creating a perfusable 3D proximal tubule model composed of epithelial cells isolated from kidney ...
Jeffrey O. Aceves, Szilvia Heja, Kenichi Kobayashi, Sanlin S. Robinson, Tomoya Miyoshi, Takuya Matsumoto, Olivier J. M. Schäffers, Ryuji Morizane, Jennifer A. Lewis   +8 more
doaj   +1 more source