Results 71 to 80 of about 4,120 (207)

Halting the Progression of Acute Kidney Injury: A Tubular‐Inspired Reusable Detoxifier Against Protein‐Bound Uremic Toxins and Oxidative Stress

SusMat, Volume 6, Issue 5, October 2026.
This graphical ToC illustrates a tubular‐inspired detoxifier (SDCMs–DS) that halts acute kidney injury progression. Inspired by proximal tubular epithelial cells (PTECs), the biomimetic design combines dissociation‐adsorption clearance of protein‐bound uremic toxins (PBUTs) with antioxidant protection. During hemoperfusion, danshensu (DS) released from
Yilin Wang, Jiahao Liang, Xijing Yang, Xin Song, Yujie Xiao, Xiran Zhou, Hongyu Xiang, Shujing Wang, Shengjun Cheng, Xianda Liu, Yu Chen, Weifeng Zhao, Changsheng Zhao   +12 more
wiley   +1 more source

Effect of application at Shu-Mu acupoint on serum uric acid in hyperuricemic rats

针刺研究, 2021
Objective To observe the effect of application at Back-Shu with Front-Mu acupoints on serum uric acid(SUA) and kidney uric acid transport related proteins in hyperuricemia rats, so as to explore the mechanism of Shu-Mu acupoint application on treatment ...
LIU Jia-nan, TANG Xue-qing, HE Xiao-qian, WU Xue-mei, SUI Ming-he   +4 more
doaj   +2 more sources

Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity [PDF]

Kidney International, 1999
Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity.Cephaloridine (CER) has been used to elucidate the mechanisms of cephalosporin antibiotic-induced nephrotoxicity. Organic anion transporters have been thought to mediate CER uptake by the proximal tubule.
Takeda, Michio, Tojo, Akihiro, Sekine, Takashi, Hosoyamada, Makoto, Kanai, Yoshikatsu, Endou, Hitoshi   +5 more
openaire   +2 more sources

Real‐World Claims Data on Prescribed Drugs and the Associated Drug–Drug Interaction Risk in Sickle Cell Disease in the United States

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
Real‐world prescription data from 6230 adolescents and adults living with sickle cell disease (SCD) were combined with a drug–drug interaction (DDI) database to characterize the population‐level DDI risk. The findings support a DDI risk assessment for development of novel SCD therapies and during clinical management of SCD.ABSTRACTSickle cell disease ...
Rune Aabjerg Nørgaard, Laura Grenier, Peter Bruun‐Rasmussen, Ifeyinwa Osunkwo, Carolina Säll   +4 more
wiley   +1 more source

Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition

, 2004
In rats, the secretion of p-aminohippurate (PAH) by the kidney is higher in males ( M) than in females ( F). The role of the major renal PAH transporters, OAT1 and OAT3, in the generation of these gender differences, as well as the responsible hormones ...
Burckhardt, Gerhard, Bahn, A., Sabolic, Ivan, Hagos, Yohannes, Ljubojevic, M., Endou, H., Herak-Kramberger, C. M.   +6 more
core   +1 more source

From Real World Data to Real Impact: A Co‐Medication Framework for Lung Cancer to Advance DDI Assessment and Patient‐Centric Drug Development

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
ABSTRACT Lung cancer predominantly affects older adults who already experience comorbidities and are at increased risk of drug–drug interactions (DDIs) due to polypharmacy. Traditional DDI assessments often do not fully capture complex co‐medication patterns observed in real‐world practice due to the risk of introducing confounding factors.
Mareena Biju, HeeJae Choi, Shilpa Madari, Annie Carlisle, Ashish Sharma, Christina Kunz, Fenglei Huang   +6 more
wiley   +1 more source

Organic anion transporters 1 (OAT1) and OAT3 meditated the protective effect of rhein on methotrexate-induced nephrotoxicity

, 2017
Rhein protects methotrexate induced kidney damage mediated by OAT1 and OAT3.
Huijun Sun, Xiaodong Ma, Kexin Liu, Changyuan Wang, Pengyuan Sun, Xiaobo Yang, Xiaokui Huo, Zhihao Liu, Yongming Jia, Qiang Meng, Jinyong Peng   +10 more
core   +1 more source

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 614-638, September 2026.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Analyses of 5′ regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3) [PDF]

Journal of Human Genetics, 2006
Kidney excretion of numerous organic anionic drugs and endogenous metabolites is carried out by a family of multispecific organic anion transporters (OATs). Two closely related transporters, SLC22A6, initially identified by us as NKT and also known as OAT1, and SLC22A8, also known as OAT3 and ROCT, are thought to mediate the initial steps in the ...
Vibha, Bhatnagar, Gang, Xu, Bruce A, Hamilton, David M, Truong, Satish A, Eraly, Wei, Wu, Sanjay K, Nigam   +6 more
openaire   +2 more sources

Metabolomic Profiling Delineates Stage‐Associated Metabolic Remodelling in Cardiovascular‐Kidney‐Metabolic Syndrome

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
Using widely targeted metabolomics, we profiled 1374 participants across CKM stages 0–4 and identified 261 metabolites exhibiting distinct, non‐linear patterns of remodelling in lipid, carbohydrate, amino acid, and redox/energy metabolism. WGCNA further identified a 148‐metabolite turquoise module associated with CKM stage, with γ‐glutamylvaline ...
Xuemei Gong, Chunyang Li, Jing Chen, Yujiao Wang, Wenge Tang, Xuehui Zhang, Jianzhong Yin, Xing Zhao, Haopeng Yu, Ping Fu, Xiaoxi Zeng   +10 more
wiley   +1 more source