Results 71 to 80 of about 5,743 (215)

Distribution of organic anion transporters NaDC3 and OAT1-3 along the human nephron [PDF]

American Journal of Physiology-Renal Physiology, 2016
The initial step in renal secretion of organic anions (OAs) is mediated by transporters in the basolateral membrane (BLM). Contributors to this process are primary active Na+-K+-ATPase (EC 3.6.3.9), secondary active Na+-dicarboxylate cotransporter 3 (NaDC3/SLC13A3), and tertiary active OA transporters (OATs) OAT1/SLC22A6, OAT2/SLC22A7, and OAT3/SLC22A8.
Breljak, Davorka, Ljubojevic, Marija, Hagos, Yohannes, Micek, Vedran, Eror, Daniela Balen, Madunic, Ivana Vrhovac, Brzica, Hrvoje, Karaica, Dean, Radovic, Nikola, Kraus, Ognjen, Anzai, Naohiko, Koepsell, Hermann, Burckhardt, Gerhard, Burckhardt, Birgitta-Christina, Sabolic, Ivan   +14 more
openaire   +5 more sources

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Orotic Aciduria [PDF]

, 2018
Orotic acid is an intermediate found in the pathway for pyrimidine synthesis. The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes the production of orotic acid by the conversion of the compound dihydroorotate to orotic acid.
Fonteh, Aliah L
core   +1 more source

Parallaxes of Five L Dwarfs with a Robotic Telescope [PDF]

, 2013
We report the parallax and proper motion of five L dwarfs obtained with observations from the robotic Liverpool Telescope. Our derived proper motions are consistent with published values and have considerably smaller errors.
A. H. Andrei, A. J. Burgasser, A. Sozzetti, B. Burningham, Burgasser A. J., Burningham B., C. J. Leigh, Casewell S. L., D. J. Pinfield, D. N. Murray, F. Marocco, H. R. A. Jones, I. A. Steele, J. R. A. Clarke, J. Yu, K. L. Cruz, R. L. Smart, Smart R. L., Y. Wang, Z. Shao, Z. Zhang, Zhang Z. H.   +21 more
core   +2 more sources

Interaction and Joint Effects of Inflammation and Triglyceride–Glucose (TyG) Index on Hyperuricemia Risk and the Mediating Role of TyG: A Cross‐Sectional Study

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
Among 5307 southern Chinese adults, higher TyG index and mINFLA score were associated with increased HUA risk and serum UA levels (p trend < 0.001). A significant interaction was observed between these two indicators. Notably, the TyG index mediated 15.4% of the mINFLA‐HUA association and 14.5% of the mINFLA‐UA association.
Xueran Huang, Pengfei Chen, Yongfen Gao, Zengnan Mo, Haiying Zhang, Rui Lin   +5 more
wiley   +1 more source

A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle

Nature Communications
A prevalent side-reaction of succinate dehydrogenase oxidizes malate to enol-oxaloacetate (OAA), a metabolically inactive form of OAA that is a strong inhibitor of succinate dehydrogenase. We purified from cow heart mitochondria an enzyme (OAT1) with OAA
Anthony J. Zmuda, Xiaojun Kang, Katie B. Wissbroecker, Katrina Freund Saxhaug, Kyle C. Costa, Adrian D. Hegeman, Thomas D. Niehaus   +6 more
doaj   +1 more source

Diagnostic and Therapeutic Roles of Extracellular Vesicles in Chronic Kidney Disease: A Systematic Review

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
This systematic review compiles and analyses 364 studies on chronic kidney disease (CKD) that investigated extracellular vesicles (EVs) for diagnostic and therapeutic applications. By systematically categorizing data according to EV source and cargo, it provides an integrated overview of EV application for CKD, highlighting common approaches and shared
Tunahan Ergunay, Alessia Brossa, Benedetta Bussolati   +2 more
wiley   +1 more source

Organic anion transporter 5 renal expression and urinary excretion in rats with vascular calcification [PDF]

, 2013
It has been described renal damage in rats with vascular calcification. The organic anion transporter 5 (Oat5) is only expressed in kidney, and its urinary excretion was proposed as potential early biomarker of renal injury.
Bulacio, Romina Paula, Hazelhoff, Maria Herminia, Torres, Adriana Monica   +2 more
core   +3 more sources

Predicting Pharmacokinetic Variability and Drug Interaction Risk Using Omics‐Based Biomarkers

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Interindividual variability in drug pharmacokinetics and susceptibility to drug–drug interactions remain major barriers in precision dosing, particularly for narrow therapeutic index drugs. While genetic factors contribute, much variability arises from dynamic influences such as physiology, disease, age, diet, microbiome, and concomitant ...
Bhagwat Prasad
wiley   +1 more source

The Uremic Toxin Indoxyl Sulfate Accelerates Senescence in Kidney Proximal Tubule Cells

Toxins, 2023
Kidney fibrosis is the common final pathway of nearly all chronic and progressive nephropathies. One cause may be the accumulation of senescent cells that secrete factors (senescence associated secretory phenotype, SASP) promoting fibrosis and ...
Yi Yang, Milos Mihajlovic, Manoe J. Janssen, Rosalinde Masereeuw   +3 more
doaj   +1 more source