Results 81 to 90 of about 4,120 (207)

Organic anion transporters and their influence on the toxicity of β-lactam antibiotics

Безопасность и риск фармакотерапии, 2018
This review article describes the classification and mechanism of action of organic anion transporters (OAT). The influence of certain members of this family of transporters on the pharmacokinetics of β-lactam antibiotics.
V. A. Evteev, O. V. Muslimova, I. A. Mazerkina, N. D. Bunyatyan, E. V. Shikh, R. E. Kazakov   +5 more
doaj  

Potential Interaction of Pinocembrin with Drug Transporters and Hepatic Drug-Metabolizing Enzymes

Pharmaceuticals
Background/Objectives: Pinocembrin is a promising drug candidate for treating ischemic stroke. The interaction of pinocembrin with drug transporters and drug-metabolizing enzymes is not fully revealed.
Sirima Sangkapat, Rattiporn Boonnop, Jeerawat Pimta, Napason Chabang, Bodee Nutho, Promsuk Jutabha, Sunhapas Soodvilai   +6 more
doaj   +1 more source

Probenecid‐Boosted Tenofovir: A Physiologically‐Based Pharmacokinetic Model‐Informed Strategy for On‐Demand HIV Preexposure Prophylaxis

CPT: Pharmacometrics & Systems Pharmacology, 2020
Multiple doses of tenofovir disoproxil fumarate (TDF) together with emtricitabine is effective for HIV preexposure prophylaxis (PrEP). TDF is converted to tenofovir (TFV) in circulation, which is subsequently cleared via tubular secretion by organic ion ...
Stephanie N. Liu, Zeruesenay Desta, Brandon T. Gufford   +2 more
doaj   +1 more source

Alignment of Micrometer‐Scale Electrospun Fibers Does Not Enhance Performance of Primary Human Renal Proximal Tubular Epithelial Cells

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 9, September 2026.
ABSTRACT Renal failure remains a leading cause of morbidity and mortality, as current renal replacement therapies restore filtration but fail to replicate the kidney's transport, metabolic, and endocrine functions. Bioengineered systems using primary renal epithelial cells show promise in recapitulating these processes, and integration into synthetic ...
IJsbrand M. Vermue, Christian G. M. van Dijk, Ihsan Chrifi, Ymke Appels, Jurjen van Meijeren, Bastiaan Terhaard, Nahid Kasaiyan, Marianne C. Verhaar, Caroline Cheng   +8 more
wiley   +1 more source

Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes

Scientific Reports, 2017
In vitro data indicates that the kidney proximal tubule (PT) transporters of uremic toxins and solutes (e.g., indoxyl sulfate, p-cresol sulfate, kynurenine, creatinine, urate) include two “drug” transporters of the organic anion transporter (OAT) family:
Wei Wu, Kevin T. Bush, Sanjay K. Nigam
doaj   +1 more source

Sex-dependent expression of Oat3 (Slc22a8) and Oat1 (Slc22a6) proteins in murine kidneys [PDF]

American Journal of Physiology-Renal Physiology, 2013
In the mouse kidney, organic anion transporter 3 (mOat3, Slc22a8) was previously localized to the basolateral membrane (BLM) of proximal tubule (PT), thick ascending limb of Henle, macula densa, distal tubule, and cortical collecting duct. However, the specificity of anti-Oat3 antibodies (Oat3-Ab) used in these studies was not properly verified ...
Breljak, Davorka, Brzica, Hrvoje, Sweet, Douglas H., Anzai, Naohiko, Sabolic, Ivan   +4 more
openaire   +4 more sources

Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors [PDF]

, 2015
The multispecific organic anion drug transporters OAT6 (SLC22A20) and OAT1 (SLC22A6) are expressed in nasal epithelial cells and both can bind odorants.
Nigam, Sanjay K, Wu, Wei, Bush, Kevin T, Zhu, Christopher, Abagyan, Ruben, Liu, Henry C   +5 more
core   +1 more source

Transporter‐Drive Interstitial Tissue Exposure and Pharmacodynamic Response of Meropenem in Sepsis: A Mechanistic PBPK Modeling Study

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT A whole‐body mechanistic PBPK model for meropenem (MPN) was developed in PK‐Sim and validated using published plasma and tissue concentration–time data in healthy volunteers and critically ill patients. Renal elimination was implemented as glomerular filtration plus active tubular secretion (basolateral uptake via OAT3 with apical efflux), and
Laura Ben Olivo, Jessica Luisa Silva de Lemos, Vinicius Jardim Rodrigues, Bibiana Verlindo de Araújo   +3 more
wiley   +1 more source

Immunolocalization of Multispecific Organic Anion Transporters, OAT1, OAT2, and OAT3, in Rat Kidney [PDF]

Journal of the American Society of Nephrology, 2002
Recently, a family of multispecific organic anion transporters has been identified, and several isoforms have been reported. However, the physiologic and pharmacologic roles of each isoform, except OAT1, in the transepithelial transport of organic anions in the kidney remain to be elucidated.
Ryoji, Kojima, Takashi, Sekine, Masanao, Kawachi, Seok Ho, Cha, Yoshio, Suzuki, Hitoshi, Endou   +5 more
openaire   +2 more sources

Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids

Journal of Nanobiotechnology, 2022
The prevalence of end-stage kidney disease (ESKD) is rapidly increasing with the need for regenerative therapies. Adult stem cell derived kidney tubuloids have the potential to functionally mimic the adult kidney tubule, but still lack the expression of ...
Rafael Soares Lindoso, Fjodor A. Yousef Yengej, Franziska Voellmy, Maarten Altelaar, Estela Mancheño Juncosa, Theano Tsikari, Carola M. E. Ammerlaan, Bas W. M. Van Balkom, Maarten B. Rookmaaker, Marianne C. Verhaar, Rosalinde Masereeuw   +10 more
doaj   +1 more source