Results 81 to 90 of about 5,743 (215)

Parametric Excitation of a Ferrimagnetic Sphere Resonator

Advanced Quantum Technologies, Volume 9, Issue 4, April 2026.
The hypothesis that disentanglement spontaneously occurs in quantum systems is experimentally tested using a ferromagnetic resonator. Predictions derived from the hypothesis, and from an alternative theoretical model, are compared with the measured response of the resonator to an externally applied driving.
Eyal Buks
wiley   +1 more source

Probenecid‐Boosted Tenofovir: A Physiologically‐Based Pharmacokinetic Model‐Informed Strategy for On‐Demand HIV Preexposure Prophylaxis

CPT: Pharmacometrics & Systems Pharmacology, 2020
Multiple doses of tenofovir disoproxil fumarate (TDF) together with emtricitabine is effective for HIV preexposure prophylaxis (PrEP). TDF is converted to tenofovir (TFV) in circulation, which is subsequently cleared via tubular secretion by organic ion ...
Stephanie N. Liu, Zeruesenay Desta, Brandon T. Gufford   +2 more
doaj   +1 more source

Evaluation of the interaction between nonsteroidal anti-inflammatory drugs and methotrexate using human organic anion transporter 3-transfected cells [PDF]

, 2008
Coadministration of methotrexate and nonsteroidal anti-inflammatory drugs (NSAIDs) can cause a pharmacokinetic interaction and a subsequent increase in blood methotrexate concentrations.
Endou Hitoshi, Fujimura Akio, Kanai Yoshikatsu, Maeda Akimitsu, Miyamoto Etsuko, Saito Kazuyuki, Tsuruoka Shuichi, 鶴岡 秀一   +7 more
core   +1 more source

Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids

Journal of Nanobiotechnology, 2022
The prevalence of end-stage kidney disease (ESKD) is rapidly increasing with the need for regenerative therapies. Adult stem cell derived kidney tubuloids have the potential to functionally mimic the adult kidney tubule, but still lack the expression of ...
Rafael Soares Lindoso, Fjodor A. Yousef Yengej, Franziska Voellmy, Maarten Altelaar, Estela Mancheño Juncosa, Theano Tsikari, Carola M. E. Ammerlaan, Bas W. M. Van Balkom, Maarten B. Rookmaaker, Marianne C. Verhaar, Rosalinde Masereeuw   +10 more
doaj   +1 more source

Effects of Maternal Low Protein Diet on Expression of Drug Transporters in the Blood-Brain Barrier of Adult Offspring [PDF]

, 2012
Adverse uterine environment, manifested as low birth weight (LBW), has been shown to predispose individuals to hypertension, diabetes, and obesity by mechanisms that are just beginning to be understood.
Hastings, Bonnie L.
core   +1 more source

Review Article: Renal Safety Profiles of Tenofovir Alafenamide, Tenofovir Disoproxil Fumarate, and Entecavir for the Treatment of Chronic Hepatitis B Infection—General and Special Populations

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 7, Page 945-954, April 2026.
Current first‐line NUCs show comparable renal safety profiles in CHB patients with no or mild kidney dysfunction, with growing evidence that favours TAF. Future prospective studies are needed to validate these findings, and more research should focus on CHB patients with diabetes mellitus who are at risk of CKD.
Lung‐Yi Mak, Tsung‐Hui Hu, Desmond Y. H. Yap   +2 more
wiley   +1 more source

Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells. [PDF]

, 2016
Genetically relevant mouse models need to recapitulate the hallmarks of human disease by permitting spatiotemporal gene targeting. This is especially important for replicating the biology of complex diseases like cancer, where genetic events occur in a ...
Adams, David J, Espana-Agusti, Judit, Fu, Beiyuan, Matakidou, Athena, Tuveson, David A, Wong, Kim, Yang, Fengtang, Zou, Xiangang   +7 more
core   +4 more sources

OAT1 and OAT3: Targets of drug–drug interaction between entecavir and JBP485

European Journal of Pharmaceutical Sciences, 2013
Entecavir and JBP485 (a dipeptide) exhibit the antihepatitis activities and it is possible for the two drugs to be coadministered in the treatment of hepatitis. We aimed to elucidate whether entecavir was a substrate of OAT1, OAT3, OCT, and PEPT1 and to investigate the targets of drug-drug interactions between entecavir and JBP485.
Qinghan, Xu, Changyuan, Wang, Qiang, Meng, Qi, Liu, Huijun, Sun, Jinyong, Peng, Xiaochi, Ma, Taiichi, Kaku, Kexin, Liu   +8 more
openaire   +2 more sources

Immunolocalization of Multispecific Organic Anion Transporters, OAT1, OAT2, and OAT3, in Rat Kidney [PDF]

Journal of the American Society of Nephrology, 2002
Recently, a family of multispecific organic anion transporters has been identified, and several isoforms have been reported. However, the physiologic and pharmacologic roles of each isoform, except OAT1, in the transepithelial transport of organic anions in the kidney remain to be elucidated.
Ryoji, Kojima, Takashi, Sekine, Masanao, Kawachi, Seok Ho, Cha, Yoshio, Suzuki, Hitoshi, Endou   +5 more
openaire   +2 more sources

Ethnic Bridging of Sepiapterin in Chinese and Korean Populations Based on Predictions From Genetic Polymorphism of Breast Cancer Resistance Protein

Clinical and Translational Science, Volume 19, Issue 4, April 2026.
ABSTRACT Ethnic differences are crucial when considering the efficacy, safety, and dose of pharmaceuticals across diverse populations. The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) guideline E5 addresses the acceptability of extrapolating foreign clinical data taking ethnic factors into ...
Lan Gao, Neil Smith, Ronald Kong
wiley   +1 more source