Results 101 to 110 of about 4,120 (207)
Inhibitory effect of JBP485 on renal excretion of acyclovir by the inhibition of OAT1 and OAT3
European Journal of Pharmaceutical Sciences, 2012 The purpose is to investigate whether the targets of drug-drug interactions (DDIs) between JBP485 and acyclovir are OAT1 and OAT3 in kidney. Plasma concentration and accumulative urinary excretion of acyclovir in vivo, uptake of acyclovir in kidney slices and uptake of acyclovir in human (h) OAT1/ hOAT3-human embryonic kidney (HEK) 293 cells in vitro ...
Jianghao, Ye +7 more
openaire +2 more sources
OAT1 and OAT3: Targets of drug–drug interaction between entecavir and JBP485
European Journal of Pharmaceutical Sciences, 2013 Entecavir and JBP485 (a dipeptide) exhibit the antihepatitis activities and it is possible for the two drugs to be coadministered in the treatment of hepatitis. We aimed to elucidate whether entecavir was a substrate of OAT1, OAT3, OCT, and PEPT1 and to investigate the targets of drug-drug interactions between entecavir and JBP485.
Qinghan, Xu +8 more
openaire +2 more sources
Expression of OAT1 and OAT3 in differentiating proximal tubules of the mouse kidney [PDF]
, 2010 Organic anion transporter 1 (OAT1) and OAT3 in the proximal tubules (PT) of the kidney play important roles in the elimination of harmful endogenous compounds and xenobiotics from the body. We investigated the temporal and spatial expression of OAT1
Kim, W.J. +4 more
core
No binding of HNRNPK to -164/-131 OAT1 promoter fragment
, 2019 (A) OK cells were transiently transfected with ERaexpression vector and incubated with 17b-estradiol for 43 h prior nuclear extract preparation.
Henjakovic (6425543)
core +1 more source
, 2018 Predicting pharmacokinetics of drug transporter substrates using PBPK modeling requires accurate transport kinetics in vitro. It is unclear what effect incubation time has on transport kinetics under initial zero-trans conditions.
Buaben, Aaron
core
Expression and protein localization of Oat1, Oat3, Oct1, and Hnf4α in the proximal tubule.
, 2013 Evidence from existing literature validates the result of microarray analysis. The genes and protein products of Hnf4α, Oat1, Oat3, and Oct1 are present in the proximal tubule during organogenesis and adulthood.
Gleb Martovetsky (315935) +4 more
core +1 more source
No binding of ER alpha to OAT1 promoter DNA
, 2019 Biotin (B)-labeled oligonucleotides from -198 to -53 of human OAT1 promoter were used. Boxes represent predicted ER alpha binding sites. ER alpha probe, harboring a perfect estrogen receptor binding site (ERE: 5’- AGGTCACTGTGACC - 3’) was generated and ...
Henjakovic (6425543) +1 more
core +1 more source
BiomedicinesBackground/Objectives: The kidneys are essential for eliminating drugs and chemicals from the human body and renal epithelial cells are particularly vulnerable to damage caused by xenobiotics and their metabolites. Drug-induced kidney toxicity is a major
Courtney Sakolish +10 more
doaj +1 more source
Structures and membrane interactions of human OAT1 in complex with clinical used drugs
Science AdvancesOrganic anion transporters (OATs) in mammals mediate the renal excretion of numerous structurally diverse organic anionic compounds. Therapeutically inhibiting OATs has emerged as a strategy to modulate the elimination or retention of these substrates.
Xuening Wu +7 more
openaire +2 more sources
iScienceSummary: Renal transporters play critical roles in predicting potential drug-drug interactions. However, current in vitro models often fail to adequately express these transporters, particularly solute carrier proteins, including organic anion ...
Cheng Ma +7 more
doaj +1 more source